product summary
company name :
Neuromab
product type :
antibody
product name :
Kv1.2 K+ channel
catalog :
75-008
quantity :
100 ug
price :
319 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
K14/16
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section, immunohistochemistry - free floating section, western blot knockout validation
more info or order :
citations: 127
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:200; loading ...; fig 2
  • western blot; mouse; 1:1000; loading ...; fig 3g
Saifetiarova J, Bhat M. Ablation of cytoskeletal scaffolding proteins, Band 4.1B and Whirlin, leads to cerebellar purkinje axon pathology and motor dysfunction. J Neurosci Res. 2019;97:313-331 pubmed publisher
  • immunocytochemistry; mouse; fig 2a
  • western blot; mouse; loading ...; fig 2f
Yang Y, Arsenault J, Bah A, Krzeminski M, Fekete A, Chao O, et al. Identification of a molecular locus for normalizing dysregulated GABA release from interneurons in the Fragile X brain. Mol Psychiatry. 2018;: pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 4c
Browne L, Smith K, Jagger D. Identification of Persistent and Resurgent Sodium Currents in Spiral Ganglion Neurons Cultured from the Mouse Cochlea. Eneuro. 2017;4: pubmed publisher
  • immunocytochemistry; mouse; 1:200; fig 3e
Taylor A, Saifetiarova J, Bhat M. Postnatal Loss of Neuronal and Glial Neurofascins Differentially Affects Node of Ranvier Maintenance and Myelinated Axon Function. Front Cell Neurosci. 2017;11:11 pubmed publisher
  • immunohistochemistry; mouse; 1:500
Fernando R, Cotter L, Perrin Tricaud C, Berthelot J, Bartolami S, Pereira J, et al. Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway. Nat Commun. 2016;7:12186 pubmed publisher
  • western blot; mouse; fig 7
Frank R, Komiyama N, Ryan T, Zhu F, O Dell T, Grant S. NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation. Nat Commun. 2016;7:11264 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; fig 2
Kawabata S, Takano M, Numasawa Kuroiwa Y, Itakura G, Kobayashi Y, Nishiyama Y, et al. Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury. Stem Cell Reports. 2016;6:1-8 pubmed publisher
  • western blot; mouse; 1:2
Nieves Cintrón M, Nystoriak M, Prada M, Johnson K, Fayer W, Dell Acqua M, et al. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes. J Biol Chem. 2015;290:7918-29 pubmed publisher
  • western blot; mouse; 1:1000; fig 3b
Yokoi N, Fukata Y, Kase D, Miyazaki T, Jaegle M, Ohkawa T, et al. Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy. Nat Med. 2015;21:19-26 pubmed publisher
  • western blot; mouse; fig 4
Chang K, Zollinger D, Susuki K, Sherman D, Makara M, Brophy P, et al. Glial ankyrins facilitate paranodal axoglial junction assembly. Nat Neurosci. 2014;17:1673-81 pubmed publisher
  • immunohistochemistry - free floating section; rat; 10 ug/ml
King A, Manning C, Trimmer J. A unique ion channel clustering domain on the axon initial segment of mammalian neurons. J Comp Neurol. 2014;522:2594-608 pubmed publisher
Cordeiro S, Finol Urdaneta R, Köpfer D, Markushina A, Song J, French R, et al. Conotoxin κM-RIIIJ, a tool targeting asymmetric heteromeric Kv1 channels. Proc Natl Acad Sci U S A. 2019;116:1059-1064 pubmed publisher
Shi Q, Saifetiarova J, Taylor A, Bhat M. mTORC1 Activation by Loss of Tsc1 in Myelinating Glia Causes Downregulation of Quaking and Neurofascin 155 Leading to Paranodal Domain Disorganization. Front Cell Neurosci. 2018;12:201 pubmed publisher
Susuki K, Zollinger D, Chang K, Zhang C, Huang C, Tsai C, et al. Glial βII Spectrin Contributes to Paranode Formation and Maintenance. J Neurosci. 2018;38:6063-6075 pubmed publisher
Zhou L, Zhou L, Su L, Cao S, Xie Y, Wang N, et al. Celecoxib Ameliorates Seizure Susceptibility in Autosomal Dominant Lateral Temporal Epilepsy. J Neurosci. 2018;38:3346-3357 pubmed publisher
Nguyen L, Anderson A. mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy. Sci Rep. 2018;8:3568 pubmed publisher
Huang C, Zhang C, Zollinger D, Leterrier C, Rasband M. An αII Spectrin-Based Cytoskeleton Protects Large-Diameter Myelinated Axons from Degeneration. J Neurosci. 2017;37:11323-11334 pubmed publisher
Huang C, Zhang C, Ho T, Oses Prieto J, Burlingame A, Lalonde J, et al. αII Spectrin Forms a Periodic Cytoskeleton at the Axon Initial Segment and Is Required for Nervous System Function. J Neurosci. 2017;37:11311-11322 pubmed publisher
Stange Marten A, Nabel A, Sinclair J, Fischl M, Alexandrova O, Wohlfrom H, et al. Input timing for spatial processing is precisely tuned via constant synaptic delays and myelination patterns in the auditory brainstem. Proc Natl Acad Sci U S A. 2017;114:E4851-E4858 pubmed publisher
Saifetiarova J, Liu X, Taylor A, Li J, Bhat M. Axonal domain disorganization in Caspr1 and Caspr2 mutant myelinated axons affects neuromuscular junction integrity, leading to muscle atrophy. J Neurosci Res. 2017;95:1373-1390 pubmed publisher
Hivert B, Pinatel D, Labasque M, Tricaud N, Goutebroze L, Faivre Sarrailh C. Assembly of juxtaparanodes in myelinating DRG culture: Differential clustering of the Kv1/Caspr2 complex and scaffolding protein 4.1B. Glia. 2016;64:840-52 pubmed publisher
Baronas V, Yang R, Vilin Y, Kurata H. Determinants of frequency-dependent regulation of Kv1.2-containing potassium channels. Channels (Austin). 2016;10:158-66 pubmed publisher
Peltola M, Kuja Panula J, Liuhanen J, Võikar V, Piepponen P, Hiekkalinna T, et al. AMIGO-Kv2.1 Potassium Channel Complex Is Associated With Schizophrenia-Related Phenotypes. Schizophr Bull. 2016;42:191-201 pubmed publisher
Brügger V, Engler S, Pereira J, Ruff S, Horn M, Welzl H, et al. HDAC1/2-Dependent P0 Expression Maintains Paranodal and Nodal Integrity Independently of Myelin Stability through Interactions with Neurofascins. PLoS Biol. 2015;13:e1002258 pubmed publisher
Ford M, Alexandrova O, Cossell L, Stange Marten A, Sinclair J, Kopp Scheinpflug C, et al. Tuning of Ranvier node and internode properties in myelinated axons to adjust action potential timing. Nat Commun. 2015;6:8073 pubmed publisher
Kole M, Qian J, Waase M, Klassen T, Chen T, Augustine G, et al. Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing. J Neurosci. 2015;35:11433-44 pubmed publisher
Smith K, Browne L, Selwood D, McAlpine D, Jagger D. Phosphoinositide Modulation of Heteromeric Kv1 Channels Adjusts Output of Spiral Ganglion Neurons from Hearing Mice. J Neurosci. 2015;35:11221-32 pubmed publisher
van Vliet A, Tannemaat M, van Duinen S, Verhaagen J, Malessy M, De Winter F. Human Neuroma-in-Continuity Contains Focal Deficits in Myelination. J Neuropathol Exp Neurol. 2015;74:901-11 pubmed publisher
Hirono M, Ogawa Y, Misono K, Zollinger D, Trimmer J, Rasband M, et al. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells. J Neurosci. 2015;35:7082-94 pubmed publisher
Yoo S, Motari M, Susuki K, Prendergast J, Mountney A, Hurtado A, et al. Sialylation regulates brain structure and function. FASEB J. 2015;29:3040-53 pubmed publisher
Syrbe S, Hedrich U, Riesch E, Djémié T, Müller S, Møller R, et al. De novo loss- or gain-of-function mutations in KCNA2 cause epileptic encephalopathy. Nat Genet. 2015;47:393-399 pubmed publisher
Baronas V, McGuinness B, Brigidi G, Gomm Kolisko R, Vilin Y, Kim R, et al. Use-dependent activation of neuronal Kv1.2 channel complexes. J Neurosci. 2015;35:3515-24 pubmed publisher
Miyazaki H, Oyama F, Inoue R, Aosaki T, Abe T, Kiyonari H, et al. Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum. Nat Commun. 2014;5:5525 pubmed publisher
Salewski R, Mitchell R, Shen C, Fehlings M. Transplantation of neural stem cells clonally derived from embryonic stem cells promotes recovery after murine spinal cord injury. Stem Cells Dev. 2015;24:36-50 pubmed publisher
Zenker J, Stettner M, Ruskamo S, Domènech Estévez E, Baloui H, Medard J, et al. A role of peripheral myelin protein 2 in lipid homeostasis of myelinating Schwann cells. Glia. 2014;62:1502-12 pubmed publisher
Dufour M, Woodhouse A, Goaillard J. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development. J Neurosci Res. 2014;92:981-99 pubmed publisher
Lehnert S, Ford M, Alexandrova O, Hellmundt F, Felmy F, Grothe B, et al. Action potential generation in an anatomically constrained model of medial superior olive axons. J Neurosci. 2014;34:5370-84 pubmed publisher
Kim K, Scholl E, Liu X, Shepherd A, Haeseleer F, Lee A. Localization and expression of CaBP1/caldendrin in the mouse brain. Neuroscience. 2014;268:33-47 pubmed publisher
Bagchi B, Al Sabi A, Kaza S, Scholz D, O Leary V, Dolly J, et al. Disruption of myelin leads to ectopic expression of K(V)1.1 channels with abnormal conductivity of optic nerve axons in a cuprizone-induced model of demyelination. PLoS ONE. 2014;9:e87736 pubmed publisher
Speca D, Ogata G, Mandikian D, Bishop H, Wiler S, Eum K, et al. Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability. Genes Brain Behav. 2014;13:394-408 pubmed publisher
Fan L, Guan X, Wang W, Zhao J, Zhang H, Tiwari V, et al. Impaired neuropathic pain and preserved acute pain in rats overexpressing voltage-gated potassium channel subunit Kv1.2 in primary afferent neurons. Mol Pain. 2014;10:8 pubmed publisher
Barry J, Gu Y, Jukkola P, O NEILL B, GU H, Mohler P, et al. Ankyrin-G directly binds to kinesin-1 to transport voltage-gated Na+ channels into axons. Dev Cell. 2014;28:117-31 pubmed publisher
Liu Q, Lee E, Davis R. Heterogeneous intrinsic excitability of murine spiral ganglion neurons is determined by Kv1 and HCN channels. Neuroscience. 2014;257:96-110 pubmed publisher
Green J, Yang J, Grati M, Kachar B, Bhat M. Whirlin, a cytoskeletal scaffolding protein, stabilizes the paranodal region and axonal cytoskeleton in myelinated axons. BMC Neurosci. 2013;14:96 pubmed publisher
Kyle B, Ahrendt E, Braun A, Braun J. The large conductance, calcium-activated K+ (BK) channel is regulated by cysteine string protein. Sci Rep. 2013;3:2447 pubmed publisher
Ruff C, Ye H, Legasto J, Stribbell N, Wang J, Zhang L, et al. Effects of adult neural precursor-derived myelination on axonal function in the perinatal congenitally dysmyelinated brain: optimizing time of intervention, developing accurate prediction models, and enhancing performance. J Neurosci. 2013;33:11899-915 pubmed publisher
Wang W, Kim H, Lv P, TEMPEL B, Yamoah E. Association of the Kv1 family of K+ channels and their functional blueprint in the properties of auditory neurons as revealed by genetic and functional analyses. J Neurophysiol. 2013;110:1751-64 pubmed publisher
Golan N, Kartvelishvily E, Spiegel I, Salomon D, Sabanay H, Rechav K, et al. Genetic deletion of Cadm4 results in myelin abnormalities resembling Charcot-Marie-Tooth neuropathy. J Neurosci. 2013;33:10950-61 pubmed publisher
Zhao X, Tang Z, Zhang H, Atianjoh F, Zhao J, Liang L, et al. A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons. Nat Neurosci. 2013;16:1024-31 pubmed publisher
Buffington S, Rasband M. Na+ channel-dependent recruitment of Nav?4 to axon initial segments and nodes of Ranvier. J Neurosci. 2013;33:6191-202 pubmed publisher
Brewster A, Lugo J, Patil V, Lee W, Qian Y, Vanegas F, et al. Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage. PLoS ONE. 2013;8:e57808 pubmed publisher
Campanac E, Gasselin C, Baude A, Rama S, Ankri N, Debanne D. Enhanced intrinsic excitability in basket cells maintains excitatory-inhibitory balance in hippocampal circuits. Neuron. 2013;77:712-22 pubmed publisher
Lee S, Sha D, Mohammed A, Asress S, Glass J, Chin L, et al. Motor and sensory neuropathy due to myelin infolding and paranodal damage in a transgenic mouse model of Charcot-Marie-Tooth disease type 1C. Hum Mol Genet. 2013;22:1755-70 pubmed publisher
Ovsepian S, Steuber V, Le Berre M, O Hara L, O Leary V, Dolly J. A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets. J Physiol. 2013;591:1771-91 pubmed publisher
Takano M, Hikishima K, Fujiyoshi K, Shibata S, Yasuda A, Konomi T, et al. MRI characterization of paranodal junction failure and related spinal cord changes in mice. PLoS ONE. 2012;7:e52904 pubmed publisher
Sanchez Ponce D, DeFelipe J, Garrido J, Munoz A. Developmental expression of Kv potassium channels at the axon initial segment of cultured hippocampal neurons. PLoS ONE. 2012;7:e48557 pubmed publisher
Uchida N, Chen K, Dohse M, Hansen K, Dean J, Buser J, et al. Human neural stem cells induce functional myelination in mice with severe dysmyelination. Sci Transl Med. 2012;4:155ra136 pubmed publisher
Sanchez J, Seidl A, Rubel E, Barria A. Control of neuronal excitability by NMDA-type glutamate receptors in early developing binaural auditory neurons. J Physiol. 2012;590:4801-18 pubmed publisher
Seidl A, Sanchez J, Schecterson L, Tabor K, Wang Y, Kashima D, et al. Transgenic quail as a model for research in the avian nervous system: a comparative study of the auditory brainstem. J Comp Neurol. 2013;521:5-23 pubmed publisher
Williams M, Fuchs J, Green J, Morielli A. Cellular mechanisms and behavioral consequences of Kv1.2 regulation in the rat cerebellum. J Neurosci. 2012;32:9228-37 pubmed publisher
Oluich L, Stratton J, Xing Y, Ng S, Cate H, Sah P, et al. Targeted ablation of oligodendrocytes induces axonal pathology independent of overt demyelination. J Neurosci. 2012;32:8317-30 pubmed publisher
Manning C, Bundros A, Trimmer J. Benefits and pitfalls of secondary antibodies: why choosing the right secondary is of primary importance. PLoS ONE. 2012;7:e38313 pubmed publisher
Zenker J, Poirot O, de Preux Charles A, Arnaud E, Medard J, Lacroix C, et al. Altered distribution of juxtaparanodal kv1.2 subunits mediates peripheral nerve hyperexcitability in type 2 diabetes mellitus. J Neurosci. 2012;32:7493-8 pubmed publisher
Glasscock E, Qian J, Kole M, Noebels J. Transcompartmental reversal of single fibre hyperexcitability in juxtaparanodal Kv1.1-deficient vagus nerve axons by activation of nodal KCNQ channels. J Physiol. 2012;590:3913-26 pubmed publisher
Jukkola P, Lovett Racke A, Zamvil S, Gu C. K+ channel alterations in the progression of experimental autoimmune encephalomyelitis. Neurobiol Dis. 2012;47:280-93 pubmed publisher
Powers B, Lasiene J, Plemel J, Shupe L, Perlmutter S, Tetzlaff W, et al. Axonal thinning and extensive remyelination without chronic demyelination in spinal injured rats. J Neurosci. 2012;32:5120-5 pubmed publisher
Buttermore E, Piochon C, Wallace M, Philpot B, Hansel C, Bhat M. Pinceau organization in the cerebellum requires distinct functions of neurofascin in Purkinje and basket neurons during postnatal development. J Neurosci. 2012;32:4724-42 pubmed publisher
Irani S, Pettingill P, Kleopa K, Schiza N, Waters P, Mazia C, et al. Morvan syndrome: clinical and serological observations in 29 cases. Ann Neurol. 2012;72:241-55 pubmed publisher
Dhaunchak A, Becker C, Schulman H, de Faria O, Rajasekharan S, Banwell B, et al. Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis. Ann Neurol. 2012;71:601-13 pubmed publisher
Deverman B, Patterson P. Exogenous leukemia inhibitory factor stimulates oligodendrocyte progenitor cell proliferation and enhances hippocampal remyelination. J Neurosci. 2012;32:2100-9 pubmed publisher
Ivanovic A, Horresh I, Golan N, Spiegel I, Sabanay H, Frechter S, et al. The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves. J Cell Biol. 2012;196:337-44 pubmed publisher
Shimoda Y, Koseki F, Itoh M, Toyoshima M, Watanabe K. A cis-complex of NB-2/contactin-5 with amyloid precursor-like protein 1 is localized on the presynaptic membrane. Neurosci Lett. 2012;510:148-53 pubmed publisher
He S, Shao L, Rittase W, Bausch S. Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR. Neuropsychopharmacology. 2012;37:1338-56 pubmed publisher
Kaphzan H, Buffington S, Jung J, Rasband M, Klann E. Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome. J Neurosci. 2011;31:17637-48 pubmed publisher
Peltola M, Kuja Panula J, Lauri S, Taira T, Rauvala H. AMIGO is an auxiliary subunit of the Kv2.1 potassium channel. EMBO Rep. 2011;12:1293-9 pubmed publisher
Duflocq A, Chareyre F, Giovannini M, Couraud F, Davenne M. Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B. BMC Biol. 2011;9:66 pubmed publisher
Joseph B, Thakali K, Pathan A, Kang E, Rusch N, Rhee S. Postsynaptic density-95 scaffolding of Shaker-type K? channels in smooth muscle cells regulates the diameter of cerebral arteries. J Physiol. 2011;589:5143-52 pubmed publisher
Shakkottai V, do Carmo Costa M, Dell Orco J, Sankaranarayanan A, Wulff H, Paulson H. Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3. J Neurosci. 2011;31:13002-14 pubmed publisher
Lysakowski A, Gaboyard Niay S, Calin Jageman I, Chatlani S, Price S, Eatock R. Molecular microdomains in a sensory terminal, the vestibular calyx ending. J Neurosci. 2011;31:10101-14 pubmed publisher
Wykes R, Kalmbach A, Eliava M, Waters J. Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice. Neurobiol Aging. 2012;33:1609-23 pubmed publisher
Brandao K, Dell Acqua M, Levinson S. A-kinase anchoring protein 150 expression in a specific subset of TRPV1- and CaV 1.2-positive nociceptive rat dorsal root ganglion neurons. J Comp Neurol. 2012;520:81-99 pubmed publisher
Hirtz J, Boesen M, Braun N, Deitmer J, Kramer F, Lohr C, et al. Cav1.3 calcium channels are required for normal development of the auditory brainstem. J Neurosci. 2011;31:8280-94 pubmed publisher
Buttermore E, Dupree J, Cheng J, An X, Tessarollo L, Bhat M. The cytoskeletal adaptor protein band 4.1B is required for the maintenance of paranodal axoglial septate junctions in myelinated axons. J Neurosci. 2011;31:8013-24 pubmed publisher
Shroff S, Mierzwa A, Scherer S, Peles E, Arévalo J, Chao M, et al. Paranodal permeability in "myelin mutants". Glia. 2011;59:1447-57 pubmed publisher
Gu C, Gu Y. Clustering and activity tuning of Kv1 channels in myelinated hippocampal axons. J Biol Chem. 2011;286:25835-47 pubmed publisher
Gross C, Yao X, Pong D, Jeromin A, Bassell G. Fragile X mental retardation protein regulates protein expression and mRNA translation of the potassium channel Kv4.2. J Neurosci. 2011;31:5693-8 pubmed publisher
Vacher H, Yang J, Cerda O, Autillo Touati A, Dargent B, Trimmer J. Cdk-mediated phosphorylation of the Kv?2 auxiliary subunit regulates Kv1 channel axonal targeting. J Cell Biol. 2011;192:813-24 pubmed publisher
Al Sabi A, Kaza S, Le Berre M, O Hara L, Bodeker M, Wang J, et al. Position-dependent attenuation by Kv1.6 of N-type inactivation of Kv1.4-containing channels. Biochem J. 2011;438:389-96 pubmed publisher
Pohl H, Porcheri C, Mueggler T, Bachmann L, Martino G, Riethmacher D, et al. Genetically induced adult oligodendrocyte cell death is associated with poor myelin clearance, reduced remyelination, and axonal damage. J Neurosci. 2011;31:1069-80 pubmed publisher
Fulton S, Thibault D, Mendez J, Lahaie N, Tirotta E, Borrelli E, et al. Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow. J Biol Chem. 2011;286:9360-72 pubmed publisher
Karcz A, Hennig M, Robbins C, Tempel B, Rubsamen R, Kopp Scheinpflug C. Low-voltage activated Kv1.1 subunits are crucial for the processing of sound source location in the lateral superior olive in mice. J Physiol. 2011;589:1143-57 pubmed publisher
Song M, Moon Y, Shin S, Kim T, Yune T, Park K. Contribution of the delayed-rectifier potassium channel Kv2.1 to acute spinal cord injury in rats. BMB Rep. 2010;43:756-60 pubmed publisher
Chang K, Susuki K, Dours Zimmermann M, Zimmermann D, Rasband M. Oligodendrocyte myelin glycoprotein does not influence node of ranvier structure or assembly. J Neurosci. 2010;30:14476-81 pubmed publisher
Devaux J. The C-terminal domain of ßIV-spectrin is crucial for KCNQ2 aggregation and excitability at nodes of Ranvier. J Physiol. 2010;588:4719-30 pubmed publisher
Shepherd M, Pomicter A, Velazco C, Henderson S, Dupree J. Paranodal reorganization results in the depletion of transverse bands in the aged central nervous system. Neurobiol Aging. 2012;33:203.e13-24 pubmed publisher
Zhong X, Abd Elrahman K, Liao C, El Yazbi A, Walsh E, Walsh M, et al. Stromatoxin-sensitive, heteromultimeric Kv2.1/Kv9.3 channels contribute to myogenic control of cerebral arterial diameter. J Physiol. 2010;588:4519-37 pubmed publisher
Crawford D, Mangiardi M, Song B, Patel R, Du S, Sofroniew M, et al. Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelination. Brain. 2010;133:2999-3016 pubmed publisher
Howell O, Rundle J, Garg A, Komada M, Brophy P, Reynolds R. Activated microglia mediate axoglial disruption that contributes to axonal injury in multiple sclerosis. J Neuropathol Exp Neurol. 2010;69:1017-1033 pubmed publisher
Padmanabhan K, Urban N. Intrinsic biophysical diversity decorrelates neuronal firing while increasing information content. Nat Neurosci. 2010;13:1276-82 pubmed publisher
Hovis K, Padmanabhan K, Urban N. A simple method of in vitro electroporation allows visualization, recording, and calcium imaging of local neuronal circuits. J Neurosci Methods. 2010;191:1-10 pubmed publisher
Gazula V, Strumbos J, Mei X, Chen H, Rahner C, Kaczmarek L. Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons. J Comp Neurol. 2010;518:3205-20 pubmed publisher
Mierzwa A, Arevalo J, Schiff R, Chao M, Rosenbluth J. Role of transverse bands in maintaining paranodal structure and axolemmal domain organization in myelinated nerve fibers: effect on longevity in dysmyelinated mutant mice. J Comp Neurol. 2010;518:2841-53 pubmed publisher
Horresh I, Bar V, Kissil J, Peles E. Organization of myelinated axons by Caspr and Caspr2 requires the cytoskeletal adapter protein 4.1B. J Neurosci. 2010;30:2480-9 pubmed publisher
Fukata Y, Lovero K, Iwanaga T, Watanabe A, Yokoi N, Tabuchi K, et al. Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy. Proc Natl Acad Sci U S A. 2010;107:3799-804 pubmed publisher
Ogawa Y, Oses Prieto J, Kim M, Horresh I, Peles E, Burlingame A, et al. ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons. J Neurosci. 2010;30:1038-48 pubmed publisher
Arnaud E, Zenker J, de Preux Charles A, Stendel C, Roos A, Medard J, et al. SH3TC2/KIAA1985 protein is required for proper myelination and the integrity of the node of Ranvier in the peripheral nervous system. Proc Natl Acad Sci U S A. 2009;106:17528-33 pubmed publisher
Dours Zimmermann M, Maurer K, Rauch U, Stoffel W, Fassler R, Zimmermann D. Versican V2 assembles the extracellular matrix surrounding the nodes of ranvier in the CNS. J Neurosci. 2009;29:7731-42 pubmed publisher
Tobin A, Joseph B, Al Kindi H, Albarwani S, Madden J, Nemetz L, et al. Loss of cerebrovascular Shaker-type K(+) channels: a shared vasodilator defect of genetic and renal hypertensive rats. Am J Physiol Heart Circ Physiol. 2009;297:H293-303 pubmed publisher
Dupree J, Pomicter A. Myelin, DIGs, and membrane rafts in the central nervous system. Prostaglandins Other Lipid Mediat. 2010;91:118-29 pubmed publisher
Teigler A, Komljenovic D, Draguhn A, Gorgas K, Just W. Defects in myelination, paranode organization and Purkinje cell innervation in the ether lipid-deficient mouse cerebellum. Hum Mol Genet. 2009;18:1897-908 pubmed publisher
Ogawa Y, Rasband M. Proteomic analysis of optic nerve lipid rafts reveals new paranodal proteins. J Neurosci Res. 2009;87:3502-10 pubmed publisher
Lorincz A, Nusser Z. Cell-type-dependent molecular composition of the axon initial segment. J Neurosci. 2008;28:14329-40 pubmed publisher
Miller M, Okaty B, Nelson S. Region-specific spike-frequency acceleration in layer 5 pyramidal neurons mediated by Kv1 subunits. J Neurosci. 2008;28:13716-26 pubmed publisher
Lonigro A, Devaux J. Disruption of neurofascin and gliomedin at nodes of Ranvier precedes demyelination in experimental allergic neuritis. Brain. 2009;132:260-73 pubmed publisher
Cartwright T, Schwalbe R. Atypical sialylated N-glycan structures are attached to neuronal voltage-gated potassium channels. Biosci Rep. 2009;29:301-13 pubmed publisher
Kim J, Nadal M, Clemens A, Baron M, Jung S, Misumi Y, et al. Kv4 accessory protein DPPX (DPP6) is a critical regulator of membrane excitability in hippocampal CA1 pyramidal neurons. J Neurophysiol. 2008;100:1835-47 pubmed publisher
Windrem M, Schanz S, Guo M, Tian G, Washco V, Stanwood N, et al. Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse. Cell Stem Cell. 2008;2:553-65 pubmed publisher
Johnston J, Griffin S, Baker C, Skrzypiec A, Chernova T, Forsythe I. Initial segment Kv2.2 channels mediate a slow delayed rectifier and maintain high frequency action potential firing in medial nucleus of the trapezoid body neurons. J Physiol. 2008;586:3493-509 pubmed publisher
Ogawa Y, Horresh I, Trimmer J, Bredt D, Peles E, Rasband M. Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2. J Neurosci. 2008;28:5731-9 pubmed publisher
Lasiene J, Shupe L, Perlmutter S, Horner P. No evidence for chronic demyelination in spared axons after spinal cord injury in a mouse. J Neurosci. 2008;28:3887-96 pubmed publisher
Yang J, Vacher H, Park K, Clark E, Trimmer J. Trafficking-dependent phosphorylation of Kv1.2 regulates voltage-gated potassium channel cell surface expression. Proc Natl Acad Sci U S A. 2007;104:20055-60 pubmed
Chi X, Nicol G. Manipulation of the potassium channel Kv1.1 and its effect on neuronal excitability in rat sensory neurons. J Neurophysiol. 2007;98:2683-92 pubmed
Wenzel H, Vacher H, Clark E, Trimmer J, Lee A, Sapolsky R, et al. Structural consequences of Kcna1 gene deletion and transfer in the mouse hippocampus. Epilepsia. 2007;48:2023-46 pubmed
Ogiwara I, Miyamoto H, Morita N, Atapour N, Mazaki E, Inoue I, et al. Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. J Neurosci. 2007;27:5903-14 pubmed
Vacher H, Mohapatra D, Misonou H, Trimmer J. Regulation of Kv1 channel trafficking by the mamba snake neurotoxin dendrotoxin K. FASEB J. 2007;21:906-14 pubmed
Gu C, Zhou W, Puthenveedu M, Xu M, Jan Y, Jan L. The microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targeting. Neuron. 2006;52:803-16 pubmed
Van Wart A, Trimmer J, Matthews G. Polarized distribution of ion channels within microdomains of the axon initial segment. J Comp Neurol. 2007;500:339-52 pubmed
product information
TargetType :
K+ channels
Target :
Kv1.2 K+ channel
AccessionNum :
P16389
Clone :
K14/16
HumanGeneName :
KCNA2
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/K14_16.pdf
IsoType :
IgG2b
ValidationT :
Pass
ValidationBrIB :
Pass
ValidationBrIHC :
Pass
ValidationKO :
Pass
Catalog :
75-008
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States