product summary
company name :
Neuromab
product type :
antibody
product name :
Fig4/Sac3
catalog :
73-201
quantity :
5 ml
price :
269 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
N202/7
reactivity :
mouse
application :
western blot, immunohistochemistry, immunocytochemistry, western blot knockout validation
more info or order :
citations: 8
Reference
de Kovel C, Meisler M, Brilstra E, van Berkestijn F, van t Slot R, van Lieshout S, et al. Characterization of a de novo SCN8A mutation in a patient with epileptic encephalopathy. Epilepsy Res. 2014;108:1511-8 pubmed publisher
Vaccari I, Carbone A, Previtali S, Mironova Y, Alberizzi V, Noseda R, et al. Loss of Fig4 in both Schwann cells and motor neurons contributes to CMT4J neuropathy. Hum Mol Genet. 2015;24:383-96 pubmed publisher
Reifler A, Lenk G, Li X, Groom L, Brooks S, Wilson D, et al. Murine Fig4 is dispensable for muscle development but required for muscle function. Skelet Muscle. 2013;3:21 pubmed publisher
Zolov S, Bridges D, Zhang Y, Lee W, Riehle E, Verma R, et al. In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P. Proc Natl Acad Sci U S A. 2012;109:17472-7 pubmed publisher
Tahtouh T, Elkins J, Filippakopoulos P, Soundararajan M, Burgy G, Durieu E, et al. Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. J Med Chem. 2012;55:9312-30 pubmed publisher
Vaccari I, Dina G, Tronchère H, Kaufman E, Chicanne G, Cerri F, et al. Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies. PLoS Genet. 2011;7:e1002319 pubmed publisher
Yan Q, Guo J, Zhang X, Bai Y, Wang L, Li J. Trauma does not accelerate neuronal degeneration in Fig4 insufficient mice. J Neurol Sci. 2012;312:102-7 pubmed publisher
Lenk G, Ferguson C, Chow C, Jin N, Jones J, Grant A, et al. Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J. PLoS Genet. 2011;7:e1002104 pubmed publisher
product information
TargetType :
Rare Disease
Target :
Fig4/Sac3
AccessionNum :
Q91WF7
Clone :
N202/7
HumanGeneName :
FIG4
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/N202_7.pdf
IsoType :
IgG1
ValidationT :
Pass
ValidationBrIB :
Pass
ValidationBrIHC :
Pass
ValidationKO :
Pass
Catalog :
73-201
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States