product summary
company name :
Neuromab
product type :
antibody
product name :
Ataxin-1, 11NQ
catalog :
73-117
quantity :
5 ml
price :
269 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
N76/8
reactivity :
mouse
application :
western blot, immunohistochemistry, immunocytochemistry, western blot knockout validation
more info or order :
citations: 5
Reference
Menon R, Soong D, de Chiara C, Holt M, Anilkumar N, Pastore A. The importance of serine 776 in Ataxin-1 partner selection: a FRET analysis. Sci Rep. 2012;2:919 pubmed publisher
Jafar Nejad P, Ward C, Richman R, Orr H, Zoghbi H. Regional rescue of spinocerebellar ataxia type 1 phenotypes by 14-3-3epsilon haploinsufficiency in mice underscores complex pathogenicity in neurodegeneration. Proc Natl Acad Sci U S A. 2011;108:2142-7 pubmed publisher
Zhang C, Browne A, Child D, Divito J, Stevenson J, Tanzi R. Loss of function of ATXN1 increases amyloid beta-protein levels by potentiating beta-secretase processing of beta-amyloid precursor protein. J Biol Chem. 2010;285:8515-26 pubmed publisher
de Chiara C, Menon R, Strom M, Gibson T, Pastore A. Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors. PLoS ONE. 2009;4:e8372 pubmed publisher
Zhai R, Zhang F, Hiesinger P, Cao Y, Haueter C, Bellen H. NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration. Nature. 2008;452:887-91 pubmed publisher
product information
TargetType :
Rare Disease
Target :
Ataxin-1, 11NQ
AccessionNum :
P54254
Clone :
N76/8
HumanGeneName :
ATXN1
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/N76_8.pdf
IsoType :
IgG2b
ValidationT :
Pass
ValidationBrIB :
Pass
ValidationBrIHC :
Pass
ValidationKO :
Pass
Catalog :
73-117
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States