product summary
company name :
Neuromab
product type :
antibody
product name :
Shank3
catalog :
73-109
quantity :
5 ml
price :
269 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
N69/46
reactivity :
rat
application :
western blot, immunocytochemistry, western blot knockout validation
more info or order :
citations: 9
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; rat; 1:100; loading ...; fig s1b
Harony Nicolas H, Kay M, du Hoffmann J, Klein M, Bozdagi Gunal O, Riad M, et al. Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat. elife. 2017;6: pubmed publisher
Farley M, Swulius M, Waxham M. Electron tomographic structure and protein composition of isolated rat cerebellar, hippocampal and cortical postsynaptic densities. Neuroscience. 2015;304:286-301 pubmed publisher
Benthani F, Tran P, Currey N, Ng I, Giry Laterriere M, Carey L, et al. Proteogenomic Analysis Identifies a Novel Human SHANK3 Isoform. Int J Mol Sci. 2015;16:11522-30 pubmed publisher
Braude J, Vijayakumar S, Baumgarner K, Laurine R, Jones T, Jones S, et al. Deletion of Shank1 has minimal effects on the molecular composition and function of glutamatergic afferent postsynapses in the mouse inner ear. Hear Res. 2015;321:52-64 pubmed publisher
Duffney L, Wei J, Cheng J, Liu W, Smith K, Kittler J, et al. Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism. J Neurosci. 2013;33:15767-78 pubmed publisher
Durand C, Perroy J, Loll F, Perrais D, Fagni L, Bourgeron T, et al. SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism. Mol Psychiatry. 2012;17:71-84 pubmed publisher
Bozdagi O, Sakurai T, Papapetrou D, Wang X, Dickstein D, Takahashi N, et al. Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication. Mol Autism. 2010;1:15 pubmed publisher
Gauthier J, Champagne N, Lafreniere R, Xiong L, Spiegelman D, Brustein E, et al. De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia. Proc Natl Acad Sci U S A. 2010;107:7863-8 pubmed publisher
Ma X, Kiraly D, Gaier E, Wang Y, Kim E, Levine E, et al. Kalirin-7 is required for synaptic structure and function. J Neurosci. 2008;28:12368-82 pubmed publisher
product information
TargetType :
Scaffolds
Target :
Shank3
AccessionNum :
Q9JLU4
Clone :
N69/46
HumanGeneName :
SHANK3
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/N69_46.pdf
IsoType :
IgG2b
ValidationT :
Pass
ValidationBrIB :
Pass
ValidationBrIHC :
ND
ValidationKO :
ND
Catalog :
73-109
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States