product summary
company name :
Neuromab
product type :
antibody
product name :
Kv1.1 K+ channel (external)
catalog :
73-105
quantity :
5 ml
price :
269 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
K36/15
reactivity :
rat
application :
western blot, immunohistochemistry, immunocytochemistry, western blot knockout validation
more info or order :
citations: 30
Published Application/Species/Sample/DilutionReference
  • western blot; rat; 1:500
Sosanya N, Brager D, Wolfe S, Niere F, Raab Graham K. Rapamycin reveals an mTOR-independent repression of Kv1.1 expression during epileptogenesis. Neurobiol Dis. 2015;73:96-105 pubmed publisher
Amor V, Zhang C, Vainshtein A, Zhang A, Zollinger D, Eshed Eisenbach Y, et al. The paranodal cytoskeleton clusters Na+ channels at nodes of Ranvier. elife. 2017;6: pubmed publisher
Zollinger D, Chang K, Baalman K, Kim S, Rasband M. The Polarity Protein Pals1 Regulates Radial Sorting of Axons. J Neurosci. 2015;35:10474-84 pubmed publisher
Chen N, Koopmans F, Gordon A, Paliukhovich I, Klaassen R, van der Schors R, et al. Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes. Biochim Biophys Acta. 2015;1854:827-33 pubmed publisher
Hoppa M, Gouzer G, Armbruster M, Ryan T. Control and plasticity of the presynaptic action potential waveform at small CNS nerve terminals. Neuron. 2014;84:778-89 pubmed publisher
Jones K, Corbin J, Huntsman M. Neonatal NMDA receptor blockade disrupts spike timing and glutamatergic synapses in fast spiking interneurons in a NMDA receptor hypofunction model of schizophrenia. PLoS ONE. 2014;9:e109303 pubmed publisher
Dufour M, Woodhouse A, Goaillard J. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development. J Neurosci Res. 2014;92:981-99 pubmed publisher
Desmazieres A, Zonta B, Zhang A, Wu L, Sherman D, Brophy P. Differential stability of PNS and CNS nodal complexes when neuronal neurofascin is lost. J Neurosci. 2014;34:5083-8 pubmed publisher
Kirizs T, Kerti Szigeti K, Lorincz A, Nusser Z. Distinct axo-somato-dendritic distributions of three potassium channels in CA1 hippocampal pyramidal cells. Eur J Neurosci. 2014;39:1771-83 pubmed publisher
Liu Q, Lee E, Davis R. Heterogeneous intrinsic excitability of murine spiral ganglion neurons is determined by Kv1 and HCN channels. Neuroscience. 2014;257:96-110 pubmed publisher
Kyle B, Ahrendt E, Braun A, Braun J. The large conductance, calcium-activated K+ (BK) channel is regulated by cysteine string protein. Sci Rep. 2013;3:2447 pubmed publisher
Sosanya N, Huang P, Cacheaux L, Chen C, Nguyen K, Perrone Bizzozero N, et al. Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1. J Cell Biol. 2013;202:53-69 pubmed publisher
Lallet Daher H, Wiel C, Gitenay D, Navaratnam N, Augert A, Le Calve B, et al. Potassium channel KCNA1 modulates oncogene-induced senescence and transformation. Cancer Res. 2013;73:5253-65 pubmed publisher
Zhao J, Zhu J, Thornhill W. Spinocerebellar ataxia-13 Kv3.3 potassium channels: arginine-to-histidine mutations affect both functional and protein expression on the cell surface. Biochem J. 2013;454:259-65 pubmed publisher
Campanac E, Gasselin C, Baude A, Rama S, Ankri N, Debanne D. Enhanced intrinsic excitability in basket cells maintains excitatory-inhibitory balance in hippocampal circuits. Neuron. 2013;77:712-22 pubmed publisher
Menegola M, Clark E, Trimmer J. The importance of immunohistochemical analyses in evaluating the phenotype of Kv channel knockout mice. Epilepsia. 2012;53 Suppl 1:142-9 pubmed publisher
Zhu J, Alsaber R, Zhao J, Ribeiro Hurley E, Thornhill W. Characterization of the Kv1.1 I262T and S342I mutations associated with episodic ataxia 1 with distinct phenotypes. Arch Biochem Biophys. 2012;524:99-105 pubmed publisher
Irani S, Pettingill P, Kleopa K, Schiza N, Waters P, Mazia C, et al. Morvan syndrome: clinical and serological observations in 29 cases. Ann Neurol. 2012;72:241-55 pubmed publisher
Bangratz M, Sarrazin N, Devaux J, Zambroni D, Echaniz Laguna A, Rene F, et al. A mouse model of Schwartz-Jampel syndrome reveals myelinating Schwann cell dysfunction with persistent axonal depolarization in vitro and distal peripheral nerve hyperexcitability when perlecan is lacking. Am J Pathol. 2012;180:2040-55 pubmed publisher
Li K, Lu Y, Xu Z, Zhang J, Zhu J, Zhang J, et al. Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy. Nat Neurosci. 2011;15:267-73 pubmed publisher
Bildl W, Haupt A, Müller C, Biniossek M, Thumfart J, Hüber B, et al. Extending the dynamic range of label-free mass spectrometric quantification of affinity purifications. Mol Cell Proteomics. 2012;11:M111.007955 pubmed publisher
Duflocq A, Chareyre F, Giovannini M, Couraud F, Davenne M. Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B. BMC Biol. 2011;9:66 pubmed publisher
Vacher H, Yang J, Cerda O, Autillo Touati A, Dargent B, Trimmer J. Cdk-mediated phosphorylation of the Kv?2 auxiliary subunit regulates Kv1 channel axonal targeting. J Cell Biol. 2011;192:813-24 pubmed publisher
Karcz A, Hennig M, Robbins C, Tempel B, Rubsamen R, Kopp Scheinpflug C. Low-voltage activated Kv1.1 subunits are crucial for the processing of sound source location in the lateral superior olive in mice. J Physiol. 2011;589:1143-57 pubmed publisher
Giacomini C, La Padula V, Schenone A, Leandri M, Contestabile A, Moruzzo D, et al. Both Schwann cell and axonal defects cause motor peripheral neuropathy in Ebf2-/- mice. Neurobiol Dis. 2011;42:73-84 pubmed publisher
Irani S, Alexander S, Waters P, Kleopa K, Pettingill P, Zuliani L, et al. Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia. Brain. 2010;133:2734-48 pubmed publisher
Lorincz A, Nusser Z. Cell-type-dependent molecular composition of the axon initial segment. J Neurosci. 2008;28:14329-40 pubmed publisher
Miller M, Okaty B, Nelson S. Region-specific spike-frequency acceleration in layer 5 pyramidal neurons mediated by Kv1 subunits. J Neurosci. 2008;28:13716-26 pubmed publisher
Goldberg E, Clark B, Zagha E, Nahmani M, Erisir A, Rudy B. K+ channels at the axon initial segment dampen near-threshold excitability of neocortical fast-spiking GABAergic interneurons. Neuron. 2008;58:387-400 pubmed publisher
Vacher H, Mohapatra D, Misonou H, Trimmer J. Regulation of Kv1 channel trafficking by the mamba snake neurotoxin dendrotoxin K. FASEB J. 2007;21:906-14 pubmed
product information
TargetType :
K+ channels
Target :
Kv1.1 K+ channel (external)
AccessionNum :
P10499
Clone :
K36/15
HumanGeneName :
KCNA1
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/K36_15.pdf
IsoType :
IgG2b
ValidationT :
Pass
ValidationBrIB :
Pass
ValidationBrIHC :
Pass
ValidationKO :
Pass
Catalog :
73-105
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States