product summary
company name :
Neuromab
product type :
antibody
product name :
TrpC5
catalog :
73-104
quantity :
5 ml
price :
269 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
N67/15
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, western blot knockout validation
more info or order :
citations: 18
Reference
Hong C, Seo H, Kwak M, Jeon J, Jang J, Jeong E, et al. Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington's disease. Brain. 2015;138:3030-47 pubmed publisher
Qiu J, Zhang C, Borgquist A, Nestor C, Smith A, Bosch M, et al. Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels. Cell Metab. 2014;19:682-93 pubmed publisher
Riccio A, Li Y, Tsvetkov E, Gapon S, Yao G, Smith K, et al. Decreased anxiety-like behavior and G?q/11-dependent responses in the amygdala of mice lacking TRPC4 channels. J Neurosci. 2014;34:3653-67 pubmed publisher
Park S, Ryu S, Yu W, Han Y, Ji Y, Oh K, et al. Leptin promotes K(ATP) channel trafficking by AMPK signaling in pancreatic ?-cells. Proc Natl Acad Sci U S A. 2013;110:12673-8 pubmed publisher
Phelan K, Shwe U, Abramowitz J, Wu H, Rhee S, Howell M, et al. Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Mol Pharmacol. 2013;83:429-38 pubmed publisher
Inoue M, Harada K, Matsuoka H, Nakamura J, Warashina A. Mechanisms and roles of muscarinic activation in guinea-pig adrenal medullary cells. Am J Physiol Cell Physiol. 2012;303:C635-44 pubmed publisher
Kaczmarek J, Riccio A, Clapham D. Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse. Proc Natl Acad Sci U S A. 2012;109:7888-92 pubmed publisher
Jeon J, Hong C, Park E, Jeon J, Cho N, Kim I, et al. Selective G?i subunits as novel direct activators of transient receptor potential canonical (TRPC)4 and TRPC5 channels. J Biol Chem. 2012;287:17029-39 pubmed publisher
Gilliam J, Wensel T. TRP channel gene expression in the mouse retina. Vision Res. 2011;51:2440-52 pubmed publisher
Kim E, Anderson M, Dryer S. Insulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species. Am J Physiol Renal Physiol. 2012;302:F298-307 pubmed publisher
Zimmermann K, Lennerz J, Hein A, Link A, Kaczmarek J, Delling M, et al. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc Natl Acad Sci U S A. 2011;108:18114-9 pubmed publisher
Qiu J, Fang Y, Bosch M, Rønnekleiv O, Kelly M. Guinea pig kisspeptin neurons are depolarized by leptin via activation of TRPC channels. Endocrinology. 2011;152:1503-14 pubmed publisher
Cvetkovic Lopes V, Eggermann E, Uschakov A, Grivel J, Bayer L, Jones B, et al. Rat hypocretin/orexin neurons are maintained in a depolarized state by TRPC channels. PLoS ONE. 2010;5:e15673 pubmed publisher
Tian D, Jacobo S, Billing D, Rozkalne A, Gage S, Anagnostou T, et al. Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels. Sci Signal. 2010;3:ra77 pubmed publisher
Salomonsson M, Braunstein T, Holstein Rathlou N, Jensen L. Na+-independent, nifedipine-resistant rat afferent arteriolar Ca2+ responses to noradrenaline: possible role of TRPC channels. Acta Physiol (Oxf). 2010;200:265-78 pubmed publisher
Hsu C, Morohashi Y, Yoshimura S, Manrique Hoyos N, Jung S, Lauterbach M, et al. Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C. J Cell Biol. 2010;189:223-32 pubmed publisher
Riccio A, Li Y, Moon J, Kim K, Smith K, Rudolph U, et al. Essential role for TRPC5 in amygdala function and fear-related behavior. Cell. 2009;137:761-72 pubmed publisher
Gomis A, Soriano S, Belmonte C, Viana F. Hypoosmotic- and pressure-induced membrane stretch activate TRPC5 channels. J Physiol. 2008;586:5633-49 pubmed publisher
product information
TargetType :
Trp channels
Target :
TrpC5
AccessionNum :
Q9UL62
Clone :
N67/15
HumanGeneName :
TRPC5
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/N67_15.pdf
IsoType :
IgG2b
ValidationT :
Pass
ValidationBrIB :
Pass
ValidationBrIHC :
Pass
ValidationKO :
Pass
Catalog :
73-104
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States