product summary
company name :
Neuromab
product type :
antibody
product name :
Nav1.7 Na+ channel
catalog :
73-103
quantity :
5 ml
price :
319 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
N68/6
reactivity :
human
application :
western blot, immunocytochemistry
more info or order :
citations: 16
Published Application/Species/Sample/DilutionReference
  • western blot; human; fig 2b
Laedermann C, Syam N, Pertin M, Decosterd I, Abriel H. ?1- and ?3- voltage-gated sodium channel subunits modulate cell surface expression and glycosylation of Nav1.7 in HEK293 cells. Front Cell Neurosci. 2013;7:137 pubmed publisher
Lu V, Ikeda S, Puhl H. A 3.7 kb fragment of the mouse Scn10a gene promoter directs neural crest but not placodal lineage EGFP expression in a transgenic animal. J Neurosci. 2015;35:8021-34 pubmed publisher
Vandael D, Ottaviani M, Legros C, Lefort C, Guérineau N, Allio A, et al. Reduced availability of voltage-gated sodium channels by depolarization or blockade by tetrodotoxin boosts burst firing and catecholamine release in mouse chromaffin cells. J Physiol. 2015;593:905-27 pubmed publisher
Campbell T, Main M, Fitzgerald E. Functional expression of the voltage-gated Na?-channel Nav1.7 is necessary for EGF-mediated invasion in human non-small cell lung cancer cells. J Cell Sci. 2013;126:4939-49 pubmed publisher
Dustrude E, Wilson S, Ju W, Xiao Y, Khanna R. CRMP2 protein SUMOylation modulates NaV1.7 channel trafficking. J Biol Chem. 2013;288:24316-31 pubmed publisher
Liang L, Fan L, Tao B, Yaster M, Tao Y. Protein kinase B/Akt is required for complete Freund's adjuvant-induced upregulation of Nav1.7 and Nav1.8 in primary sensory neurons. J Pain. 2013;14:638-47 pubmed publisher
Melemedjian O, Khoutorsky A, Sorge R, Yan J, Asiedu M, Valdez A, et al. mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK. Pain. 2013;154:1080-91 pubmed publisher
Eom T, Zhang C, Wang H, Lay K, Fak J, Noebels J, et al. NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. elife. 2013;2:e00178 pubmed publisher
Liu J, Tu H, Zhang D, Zheng H, Li Y. Voltage-gated sodium channel expression and action potential generation in differentiated NG108-15 cells. BMC Neurosci. 2012;13:129 pubmed publisher
Cachemaille M, Laedermann C, Pertin M, Abriel H, Gosselin R, Decosterd I. Neuronal expression of the ubiquitin ligase Nedd4-2 in rat dorsal root ganglia: modulation in the spared nerve injury model of neuropathic pain. Neuroscience. 2012;227:370-80 pubmed publisher
Ho C, Zhao J, Malinowski S, Chahine M, O Leary M. Differential expression of sodium channel ? subunits in dorsal root ganglion sensory neurons. J Biol Chem. 2012;287:15044-53 pubmed publisher
Yan J, Melemedjian O, Price T, Dussor G. Sensitization of dural afferents underlies migraine-related behavior following meningeal application of interleukin-6 (IL-6). Mol Pain. 2012;8:6 pubmed publisher
Tappe Theodor A, Constantin C, Tegeder I, Lechner S, Langeslag M, Lepcynzsky P, et al. G?(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization. Pain. 2012;153:184-96 pubmed publisher
Chattopadhyay M, Mata M, Fink D. Vector-mediated release of GABA attenuates pain-related behaviors and reduces Na(V)1.7 in DRG neurons. Eur J Pain. 2011;15:913-20 pubmed publisher
Cox J, Sheynin J, Shorer Z, Reimann F, Nicholas A, Zubovic L, et al. Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations. Hum Mutat. 2010;31:E1670-86 pubmed publisher
Ernst S, Aguilar Bryan L, Noebels J. Sodium channel beta1 regulatory subunit deficiency reduces pancreatic islet glucose-stimulated insulin and glucagon secretion. Endocrinology. 2009;150:1132-9 pubmed publisher
product information
TargetType :
Na+ channels
Target :
Nav1.7 Na+ channel
AccessionNum :
Q15858
Clone :
N68/6
HumanGeneName :
SCN9A
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/N68_6.pdf
IsoType :
IgG1
ValidationT :
Pass
ValidationBrIB :
NA
ValidationBrIHC :
NA
ValidationKO :
ND
Catalog :
73-103
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States