product summary
company name :
Neuromab
product type :
antibody
product name :
Kv7.2/KCNQ2 K+ channel
catalog :
73-079
quantity :
5 ml
price :
269 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
N26A/23
reactivity :
human, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section
more info or order :
citations: 14
Published Application/Species/Sample/DilutionReference
  • immunoprecipitation; rat
  • western blot; rat; 1:200
Cavaretta J, Sherer K, Lee K, Kim E, Issema R, Chung H. Polarized axonal surface expression of neuronal KCNQ potassium channels is regulated by calmodulin interaction with KCNQ2 subunit. PLoS ONE. 2014;9:e103655 pubmed publisher
  • immunohistochemistry - frozen section; rat
Buniel M, Glazebrook P, Ramirez Navarro A, Kunze D. Distribution of voltage-gated potassium and hyperpolarization-activated channels in sensory afferent fibers in the rat carotid body. J Comp Neurol. 2008;510:367-77 pubmed publisher
Wang A, Yau M, Wang C, Sharmin N, Yang R, Pless S, et al. Four drug-sensitive subunits are required for maximal effect of a voltage sensor-targeted KCNQ opener. J Gen Physiol. 2018;150:1432-1443 pubmed publisher
Salzer I, Erdem F, Chen W, Heo S, Koenig X, Schicker K, et al. Phosphorylation regulates the sensitivity of voltage-gated Kv7.2 channels towards phosphatidylinositol-4,5-bisphosphate. J Physiol. 2017;595:759-776 pubmed publisher
Ambrosino P, Alaimo A, Bartollino S, Manocchio L, De Maria M, Mosca I, et al. Epilepsy-causing mutations in Kv7.2 C-terminus affect binding and functional modulation by calmodulin. Biochim Biophys Acta. 2015;1852:1856-66 pubmed publisher
Salomonsson M, Brasen J, Braunstein T, Hagelqvist P, Holstein Rathlou N, Sorensen C. K(V)7.4 channels participate in the control of rodent renal vascular resting tone. Acta Physiol (Oxf). 2015;214:402-14 pubmed publisher
Miceli F, Soldovieri M, Ambrosino P, De Maria M, Migliore M, Migliore R, et al. Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7.2 and Kv7.3 potassium channel subunits. J Neurosci. 2015;35:3782-93 pubmed publisher
Soldovieri M, Boutry Kryza N, Milh M, Doummar D, Heron B, Bourel E, et al. Novel KCNQ2 and KCNQ3 mutations in a large cohort of families with benign neonatal epilepsy: first evidence for an altered channel regulation by syntaxin-1A. Hum Mutat. 2014;35:356-67 pubmed publisher
Evseev A, Semenov I, Archer C, Medina J, Dube P, Shapiro M, et al. Functional effects of KCNQ K(+) channels in airway smooth muscle. Front Physiol. 2013;4:277 pubmed publisher
Reilly J, Telezhkin V, Passmore G, Marsh S, Brown D. Kv7/M-type potassium channels in rat skin keratinocytes. Pflugers Arch. 2013;465:1371-81 pubmed publisher
Sanchez Ponce D, DeFelipe J, Garrido J, Munoz A. Developmental expression of Kv potassium channels at the axon initial segment of cultured hippocampal neurons. PLoS ONE. 2012;7:e48557 pubmed publisher
Kaphzan H, Buffington S, Jung J, Rasband M, Klann E. Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome. J Neurosci. 2011;31:17637-48 pubmed publisher
Klemmer P, Smit A, Li K. Proteomics analysis of immuno-precipitated synaptic protein complexes. J Proteomics. 2009;72:82-90 pubmed publisher
Wladyka C, Feng B, Glazebrook P, Schild J, Kunze D. The KCNQ/M-current modulates arterial baroreceptor function at the sensory terminal in rats. J Physiol. 2008;586:795-802 pubmed
product information
TargetType :
K+ channels
Target :
Kv7.2/KCNQ2 K+ channel
AccessionNum :
O43526
Clone :
N26A/23
HumanGeneName :
KCNQ2
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/N26A_23.pdf
IsoType :
IgG1
ValidationT :
Pass
ValidationBrIB :
Fail
ValidationBrIHC :
Pass
ValidationKO :
ND
Catalog :
73-079
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States