product summary
company name :
Neuromab
product type :
antibody
product name :
KCNT1/Slo2.2/Slack K+ channel
catalog :
73-051
quantity :
5 ml
price :
269 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
N3/26
reactivity :
mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, western blot knockout validation
more info or order :
citations: 11
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 10 ug/ml; fig 2
  • immunoprecipitation; mouse; fig 2
Martinez Espinosa P, Wu J, Yang C, González Pérez V, Zhou H, Liang H, et al. Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons. elife. 2015;4: pubmed publisher
  • western blot; mouse; fig 2
Wojtovich A, Smith C, Urciuoli W, Wang Y, Xia X, Brookes P, et al. Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning. Anesthesiology. 2016;124:1065-76 pubmed publisher
Gururaj S, Fleites J, Bhattacharjee A. Slack sodium-activated potassium channel membrane expression requires p38 mitogen-activated protein kinase phosphorylation. Neuropharmacology. 2016;103:279-89 pubmed publisher
Rizzi S, Knaus H, Schwarzer C. Differential distribution of the sodium-activated potassium channels slick and slack in mouse brain. J Comp Neurol. 2016;524:2093-116 pubmed publisher
Lu R, Bausch A, Kallenborn Gerhardt W, Stoetzer C, Debruin N, Ruth P, et al. Slack channels expressed in sensory neurons control neuropathic pain in mice. J Neurosci. 2015;35:1125-35 pubmed publisher
Huang F, Wang X, Ostertag E, Nuwal T, Huang B, Jan Y, et al. TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing. Nat Neurosci. 2013;16:1284-90 pubmed publisher
Cervantes B, Vega R, Limon A, Soto E. Identity, expression and functional role of the sodium-activated potassium current in vestibular ganglion afferent neurons. Neuroscience. 2013;240:163-75 pubmed publisher
Zhang Y, Brown M, Hyland C, Chen Y, Kronengold J, Fleming M, et al. Regulation of neuronal excitability by interaction of fragile X mental retardation protein with slack potassium channels. J Neurosci. 2012;32:15318-27 pubmed publisher
Wojtovich A, Sherman T, Nadtochiy S, Urciuoli W, Brookes P, Nehrke K. SLO-2 is cytoprotective and contributes to mitochondrial potassium transport. PLoS ONE. 2011;6:e28287 pubmed publisher
Nuwer M, Picchione K, Bhattacharjee A. PKA-induced internalization of slack KNa channels produces dorsal root ganglion neuron hyperexcitability. J Neurosci. 2010;30:14165-72 pubmed publisher
Chen H, Kronengold J, Yan Y, Gazula V, Brown M, Ma L, et al. The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels. J Neurosci. 2009;29:5654-65 pubmed publisher
product information
TargetType :
K+ channels
Target :
KCNT1/Slo2.2/Slack K+ channel
AccessionNum :
Q9Z258
Clone :
N3/26
HumanGeneName :
KCNT1
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/N3_26.pdf
IsoType :
IgG1
ValidationT :
Pass
ValidationBrIB :
Pass
ValidationBrIHC :
Pass
ValidationKO :
Pass
Catalog :
73-051
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States