product summary
company name :
Neuromab
product type :
antibody
product name :
Nav1.2 Na+ channel
catalog :
73-024
quantity :
5 ml
price :
269 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
K69/3
reactivity :
mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 41
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; fig 4
Bosch M, Nerbonne J, Townsend R, Miyazaki H, Nukina N, Ornitz D, et al. Proteomic analysis of native cerebellar iFGF14 complexes. Channels (Austin). 2016;10:297-312 pubmed publisher
  • western blot; mouse
Li T, Tian C, Scalmani P, Frassoni C, Mantegazza M, Wang Y, et al. Action potential initiation in neocortical inhibitory interneurons. PLoS Biol. 2014;12:e1001944 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500
Wang X, Hooks B, Sun Q. Thorough GABAergic innervation of the entire axon initial segment revealed by an optogenetic 'laserspritzer'. J Physiol. 2014;592:4257-76 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:500
Huang C, Chu D, Hwang W, Tsaur M. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. J Comp Neurol. 2012;520:3650-72 pubmed publisher
Yin L, Rasch M, He Q, Wu S, Dou F, Shu Y. Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron. Cereb Cortex. 2017;27:509-521 pubmed publisher
Hamada M, Kole M. Myelin loss and axonal ion channel adaptations associated with gray matter neuronal hyperexcitability. J Neurosci. 2015;35:7272-86 pubmed publisher
Wildburger N, Ali S, Hsu W, Shavkunov A, Nenov M, Lichti C, et al. Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain. Mol Cell Proteomics. 2015;14:1288-300 pubmed publisher
Wimmer V, Harty R, Richards K, Phillips A, Miyazaki H, Nukina N, et al. Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain. J Comp Neurol. 2015;523:814-30 pubmed publisher
Gazina E, Leaw B, Richards K, Wimmer V, Kim T, Aumann T, et al. 'Neonatal' Nav1.2 reduces neuronal excitability and affects seizure susceptibility and behaviour. Hum Mol Genet. 2015;24:1457-68 pubmed publisher
Tian C, Wang K, Ke W, Guo H, Shu Y. Molecular identity of axonal sodium channels in human cortical pyramidal cells. Front Cell Neurosci. 2014;8:297 pubmed publisher
Baek J, Rubinstein M, Scheuer T, Trimmer J. Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures. J Biol Chem. 2014;289:15363-73 pubmed publisher
Liu W, Deng J, Wang G, Zhang C, Luo X, Yan D, et al. KCNE2 modulates cardiac L-type Ca(2+) channel. J Mol Cell Cardiol. 2014;72:208-18 pubmed publisher
Vega A, Avila G, Matthews G. Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression. Sci Rep. 2013;3:2809 pubmed publisher
He Y, Liu D, Fang Y, Zhan X, Yao J, Mei Y. Exposure to extremely low-frequency electromagnetic fields modulates Na+ currents in rat cerebellar granule cells through increase of AA/PGE2 and EP receptor-mediated cAMP/PKA pathway. PLoS ONE. 2013;8:e54376 pubmed publisher
Martínez Hernández J, Ballesteros Merino C, Fernandez Alacid L, Nicolau J, Aguado C, Lujan R. Polarised localisation of the voltage-gated sodium channel Na(v)1.2 in cerebellar granule cells. Cerebellum. 2013;12:16-26 pubmed publisher
Dhaunchak A, Becker C, Schulman H, de Faria O, Rajasekharan S, Banwell B, et al. Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis. Ann Neurol. 2012;71:601-13 pubmed publisher
Kaphzan H, Buffington S, Jung J, Rasband M, Klann E. Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome. J Neurosci. 2011;31:17637-48 pubmed publisher
Lysakowski A, Gaboyard Niay S, Calin Jageman I, Chatlani S, Price S, Eatock R. Molecular microdomains in a sensory terminal, the vestibular calyx ending. J Neurosci. 2011;31:10101-14 pubmed publisher
Wykes R, Kalmbach A, Eliava M, Waters J. Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice. Neurobiol Aging. 2012;33:1609-23 pubmed publisher
Ahn H, Black J, Zhao P, Tyrrell L, Waxman S, Dib Hajj S. Nav1.7 is the predominant sodium channel in rodent olfactory sensory neurons. Mol Pain. 2011;7:32 pubmed publisher
Barry J, Gu Y, Gu C. Polarized targeting of L1-CAM regulates axonal and dendritic bundling in vitro. Eur J Neurosci. 2010;32:1618-31 pubmed publisher
Wimmer V, Reid C, Mitchell S, Richards K, Scaf B, Leaw B, et al. Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus. J Clin Invest. 2010;120:2661-71 pubmed publisher
Lorincz A, Nusser Z. Molecular identity of dendritic voltage-gated sodium channels. Science. 2010;328:906-9 pubmed publisher
Wimmer V, Reid C, So E, Berkovic S, Petrou S. Axon initial segment dysfunction in epilepsy. J Physiol. 2010;588:1829-40 pubmed publisher
Liao Y, Deprez L, Maljevic S, Pitsch J, Claes L, Hristova D, et al. Molecular correlates of age-dependent seizures in an inherited neonatal-infantile epilepsy. Brain. 2010;133:1403-14 pubmed publisher
Black J, Newcombe J, Waxman S. Astrocytes within multiple sclerosis lesions upregulate sodium channel Nav1.5. Brain. 2010;133:835-46 pubmed publisher
Brackenbury W, Calhoun J, Chen C, Miyazaki H, Nukina N, Oyama F, et al. Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth. Proc Natl Acad Sci U S A. 2010;107:2283-8 pubmed publisher
Berendt F, Park K, Trimmer J. Multisite phosphorylation of voltage-gated sodium channel alpha subunits from rat brain. J Proteome Res. 2010;9:1976-84 pubmed publisher
Bouvier D, Tremblay M, Riad M, Corera A, Gingras D, Horn K, et al. EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain. J Neurochem. 2010;113:153-65 pubmed publisher
Conant K, Wang Y, Szklarczyk A, Dudak A, Mattson M, Lim S. Matrix metalloproteinase-dependent shedding of intercellular adhesion molecule-5 occurs with long-term potentiation. Neuroscience. 2010;166:508-21 pubmed publisher
Merrick E, Kalmar C, Snyder S, Cusdin F, Yu E, Sando J, et al. The importance of serine 161 in the sodium channel beta3 subunit for modulation of Na(V)1.2 gating. Pflugers Arch. 2010;460:743-53 pubmed publisher
Crawford D, Mangiardi M, Xia X, López Valdés H, Tiwari Woodruff S. Functional recovery of callosal axons following demyelination: a critical window. Neuroscience. 2009;164:1407-21 pubmed publisher
Thomas E, Hawkins R, Richards K, Xu R, Gazina E, Petrou S. Heat opens axon initial segment sodium channels: a febrile seizure mechanism?. Ann Neurol. 2009;66:219-26 pubmed publisher
von Reyn C, Spaethling J, Mesfin M, Ma M, Neumar R, Smith D, et al. Calpain mediates proteolysis of the voltage-gated sodium channel alpha-subunit. J Neurosci. 2009;29:10350-6 pubmed publisher
Kress G, Dowling M, Eisenman L, Mennerick S. Axonal sodium channel distribution shapes the depolarized action potential threshold of dentate granule neurons. Hippocampus. 2010;20:558-71 pubmed publisher
O Malley H, Shreiner A, Chen G, Huffnagle G, Isom L. Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis. Mol Cell Neurosci. 2009;40:143-55 pubmed publisher
Lonigro A, Devaux J. Disruption of neurofascin and gliomedin at nodes of Ranvier precedes demyelination in experimental allergic neuritis. Brain. 2009;132:260-73 pubmed publisher
Mojumder D, Wensel T, Frishman L. Subcellular compartmentalization of two calcium binding proteins, calretinin and calbindin-28 kDa, in ganglion and amacrine cells of the rat retina. Mol Vis. 2008;14:1600-13 pubmed
Vega A, Henry D, Matthews G. Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a. Neurosci Lett. 2008;442:69-73 pubmed publisher
Zhao P, Barr T, Hou Q, Dib Hajj S, Black J, Albrecht P, et al. Voltage-gated sodium channel expression in rat and human epidermal keratinocytes: evidence for a role in pain. Pain. 2008;139:90-105 pubmed publisher
Mojumder D, Frishman L, Otteson D, Sherry D. Voltage-gated sodium channel alpha-subunits Na(v)1.1, Na(v)1.2, and Na(v)1.6 in the distal mammalian retina. Mol Vis. 2007;13:2163-82 pubmed
product information
TargetType :
Na+ channels
Target :
Nav1.2 Na+ channel
AccessionNum :
P04775
Clone :
K69/3
HumanGeneName :
SCN2A
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/K69_3.pdf
IsoType :
IgG2a
ValidationT :
Pass
ValidationBrIB :
Pass
ValidationBrIHC :
Pass
ValidationKO :
ND
Catalog :
73-024
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States