product summary
company name :
Neuromab
product type :
antibody
product name :
Kv4.3 K+ channel
catalog :
73-017
quantity :
5 ml
price :
269 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
K75/41
reactivity :
rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, western blot knockout validation
more info or order :
citations: 50
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; rat; 1:100
Huang C, Chu D, Hwang W, Tsaur M. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. J Comp Neurol. 2012;520:3650-72 pubmed publisher
Zhang X, Ai X, Nakayama H, Chen B, Harris D, Tang M, et al. Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias. Basic Res Cardiol. 2016;111:4 pubmed publisher
Cheng C, Wang W, Huang C, Du P, Yang J, Tsaur M. Coexpression of auxiliary subunits KChIP and DPPL in potassium channel Kv4-positive nociceptors and pain-modulating spinal interneurons. J Comp Neurol. 2016;524:846-73 pubmed publisher
Simkin D, Hattori S, YBARRA N, Musial T, Buss E, Richter H, et al. Aging-Related Hyperexcitability in CA3 Pyramidal Neurons Is Mediated by Enhanced A-Type K+ Channel Function and Expression. J Neurosci. 2015;35:13206-18 pubmed publisher
Liu J, Kim K, Morales M, Heximer S, Hui C, Backx P. Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes. PLoS ONE. 2015;10:e0133274 pubmed publisher
Cheng C, Cheng J, Chen C, Rau R, Chang Y, Tsaur M. Nerve growth factor-induced synapse-like structures in contralateral sensory ganglia contribute to chronic mirror-image pain. Pain. 2015;156:2295-309 pubmed publisher
You T, Mao W, Cai B, Li F, Xu H. Two novel Brugada syndrome-associated mutations increase KV4.3 membrane expression and function. Int J Mol Med. 2015;36:309-15 pubmed publisher
Duarri A, Lin M, Fokkens M, Meijer M, Smeets C, Nibbeling E, et al. Spinocerebellar ataxia type 19/22 mutations alter heterocomplex Kv4.3 channel function and gating in a dominant manner. Cell Mol Life Sci. 2015;72:3387-99 pubmed publisher
Lei Z, Zhang H, Liang Y, Cui Q, Xu Z, Xu Z. Reduced expression of IA channels is associated with postischemic seizures in hyperglycemic rats. J Neurosci Res. 2014;92:1775-84 pubmed publisher
Dufour M, Woodhouse A, Goaillard J. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development. J Neurosci Res. 2014;92:981-99 pubmed publisher
Rainnie D, Hazra R, Dabrowska J, Guo J, Li C, Dewitt S, et al. Distribution and functional expression of Kv4 family ? subunits and associated KChIP ? subunits in the bed nucleus of the stria terminalis. J Comp Neurol. 2014;522:609-25 pubmed publisher
Duarri A, Nibbeling E, Fokkens M, Meijer M, Boddeke E, Lagrange E, et al. The L450F [Corrected] mutation in KCND3 brings spinocerebellar ataxia and Brugada syndrome closer together. Neurogenetics. 2013;14:257-8 pubmed publisher
David J, Andersen M, Olesen S, Rasmussen H, Schmitt N. Trafficking of the IKs -complex in MDCK cells: site of subunit assembly and determinants of polarized localization. Traffic. 2013;14:399-411 pubmed publisher
Duarri A, Jezierska J, Fokkens M, Meijer M, Schelhaas H, den Dunnen W, et al. Mutations in potassium channel kcnd3 cause spinocerebellar ataxia type 19. Ann Neurol. 2012;72:870-80 pubmed publisher
Yao J, Gao X, Chow C, Zhan X, Hu C, Mei Y. Neuritin activates insulin receptor pathway to up-regulate Kv4.2-mediated transient outward K+ current in rat cerebellar granule neurons. J Biol Chem. 2012;287:41534-45 pubmed publisher
Matsuyoshi H, Takimoto K, Yunoki T, Erickson V, Tyagi P, Hirao Y, et al. Distinct cellular distributions of Kv4 pore-forming and auxiliary subunits in rat dorsal root ganglion neurons. Life Sci. 2012;91:258-63 pubmed publisher
Menegola M, Clark E, Trimmer J. The importance of immunohistochemical analyses in evaluating the phenotype of Kv channel knockout mice. Epilepsia. 2012;53 Suppl 1:142-9 pubmed publisher
Sethi J, Sanchez Alavez M, Tabarean I. Kv4.2 mediates histamine modulation of preoptic neuron activity and body temperature. PLoS ONE. 2011;6:e29134 pubmed publisher
Zhang Y, Wu W, Sun H, Deng X, Cheng L, Li X, et al. Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases. Cardiovasc Res. 2012;93:424-33 pubmed publisher
Zhang M, Wang Y, Jiang M, Zankov D, Chowdhury S, Kasirajan V, et al. KCNE2 protein is more abundant in ventricles than in atria and can accelerate hERG protein degradation in a phosphorylation-dependent manner. Am J Physiol Heart Circ Physiol. 2012;302:H910-22 pubmed publisher
Marshall G, Russell J, Tellez J, Jhund P, Currie S, Dempster J, et al. Remodelling of human atrial K+ currents but not ion channel expression by chronic ?-blockade. Pflugers Arch. 2012;463:537-48 pubmed publisher
Sun W, MAFFIE J, Lin L, Petralia R, Rudy B, Hoffman D. DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons. Neuron. 2011;71:1102-15 pubmed publisher
Lei Z, Deng P, Li J, Xu Z. Alterations of A-type potassium channels in hippocampal neurons after traumatic brain injury. J Neurotrauma. 2012;29:235-45 pubmed publisher
Hourez R, Servais L, Orduz D, Gall D, Millard I, de Kerchove d Exaerde A, et al. Aminopyridines correct early dysfunction and delay neurodegeneration in a mouse model of spinocerebellar ataxia type 1. J Neurosci. 2011;31:11795-807 pubmed publisher
Wykes R, Kalmbach A, Eliava M, Waters J. Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice. Neurobiol Aging. 2012;33:1609-23 pubmed publisher
Stein A, Jones T, Herron T, Patel S, Day S, Noujaim S, et al. Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes. J Clin Invest. 2011;121:2641-50 pubmed publisher
Cheng L, Yung A, Covarrubias M, Radice G. Cortactin is required for N-cadherin regulation of Kv1.5 channel function. J Biol Chem. 2011;286:20478-89 pubmed publisher
Guan D, Horton L, Armstrong W, FOEHRING R. Postnatal development of A-type and Kv1- and Kv2-mediated potassium channel currents in neocortical pyramidal neurons. J Neurophysiol. 2011;105:2976-88 pubmed publisher
Nowak A, Mathieson H, Chapman R, Janzso G, Yanagawa Y, Obata K, et al. Kv3.1b and Kv3.3 channel subunit expression in murine spinal dorsal horn GABAergic interneurones. J Chem Neuroanat. 2011;42:30-8 pubmed publisher
Pruss H, Dewes M, Derst C, Fernández Klett F, Veh R, Priller J. Potassium channel expression in adult murine neural progenitor cells. Neuroscience. 2011;180:19-29 pubmed publisher
Bourdeau M, Laplante I, Laurent C, Lacaille J. KChIP1 modulation of Kv4.3-mediated A-type K(+) currents and repetitive firing in hippocampal interneurons. Neuroscience. 2011;176:173-87 pubmed publisher
Schwetz T, Norring S, Ednie A, Bennett E. Sialic acids attached to O-glycans modulate voltage-gated potassium channel gating. J Biol Chem. 2011;286:4123-32 pubmed publisher
Norris A, Foeger N, Nerbonne J. Interdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neurons. J Neurosci. 2010;30:13644-55 pubmed publisher
Dabrowska J, Rainnie D. Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala. Neuroscience. 2010;171:721-33 pubmed publisher
Bealer S, Little J, Metcalf C, Brewster A, Anderson A. Autonomic and cellular mechanisms mediating detrimental cardiac effects of status epilepticus. Epilepsy Res. 2010;91:66-73 pubmed publisher
Norris A, Nerbonne J. Molecular dissection of I(A) in cortical pyramidal neurons reveals three distinct components encoded by Kv4.2, Kv4.3, and Kv1.4 alpha-subunits. J Neurosci. 2010;30:5092-101 pubmed publisher
Cotella D, Radicke S, Bortoluzzi A, Ravens U, Wettwer E, Santoro C, et al. Impaired glycosylation blocks DPP10 cell surface expression and alters the electrophysiology of Ito channel complex. Pflugers Arch. 2010;460:87-97 pubmed publisher
Phuket T, Covarrubias M. Kv4 Channels Underlie the Subthreshold-Operating A-type K-current in Nociceptive Dorsal Root Ganglion Neurons. Front Mol Neurosci. 2009;2:3 pubmed publisher
Jiang M, Xu X, Wang Y, Toyoda F, Liu X, Zhang M, et al. Dynamic partnership between KCNQ1 and KCNE1 and influence on cardiac IKs current amplitude by KCNE2. J Biol Chem. 2009;284:16452-62 pubmed publisher
Eyre M, Kerti K, Nusser Z. Molecular diversity of deep short-axon cells of the rat main olfactory bulb. Eur J Neurosci. 2009;29:1397-407 pubmed publisher
Clark B, Kwon E, Maffie J, Jeong H, Nadal M, Strop P, et al. DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein. Front Mol Neurosci. 2008;1:8 pubmed publisher
Monaghan M, Menegola M, Vacher H, Rhodes K, Trimmer J. Altered expression and localization of hippocampal A-type potassium channel subunits in the pilocarpine-induced model of temporal lobe epilepsy. Neuroscience. 2008;156:550-62 pubmed publisher
Menegola M, Misonou H, Vacher H, Trimmer J. Dendritic A-type potassium channel subunit expression in CA1 hippocampal interneurons. Neuroscience. 2008;154:953-64 pubmed publisher
Schwenk J, Zolles G, Kandias N, Neubauer I, Kalbacher H, Covarrubias M, et al. NMR analysis of KChIP4a reveals structural basis for control of surface expression of Kv4 channel complexes. J Biol Chem. 2008;283:18937-46 pubmed publisher
Amarillo Y, De Santiago Castillo J, Dougherty K, Maffie J, Kwon E, Covarrubias M, et al. Ternary Kv4.2 channels recapitulate voltage-dependent inactivation kinetics of A-type K+ channels in cerebellar granule neurons. J Physiol. 2008;586:2093-106 pubmed publisher
Chien L, Cheng J, Chu D, Cheng C, Tsaur M. Reduced expression of A-type potassium channels in primary sensory neurons induces mechanical hypersensitivity. J Neurosci. 2007;27:9855-65 pubmed
Bourdeau M, Morin F, Laurent C, Azzi M, Lacaille J. Kv4.3-mediated A-type K+ currents underlie rhythmic activity in hippocampal interneurons. J Neurosci. 2007;27:1942-53 pubmed
Burkhalter A, Gonchar Y, Mellor R, Nerbonne J. Differential expression of I(A) channel subunits Kv4.2 and Kv4.3 in mouse visual cortical neurons and synapses. J Neurosci. 2006;26:12274-82 pubmed
Menegola M, Trimmer J. Unanticipated region- and cell-specific downregulation of individual KChIP auxiliary subunit isotypes in Kv4.2 knock-out mouse brain. J Neurosci. 2006;26:12137-42 pubmed
Kollo M, Holderith N, Nusser Z. Novel subcellular distribution pattern of A-type K+ channels on neuronal surface. J Neurosci. 2006;26:2684-91 pubmed
product information
TargetType :
K+ channels
Target :
Kv4.3 K+ channel
AccessionNum :
Q62897
Clone :
K75/41
HumanGeneName :
KCND3
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/K75_41.pdf
IsoType :
IgG1
ValidationT :
Pass
ValidationBrIB :
Pass
ValidationBrIHC :
Pass
ValidationKO :
Pass
Catalog :
73-017
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States