product summary
company name :
Neuromab
product type :
antibody
product name :
Kv4.2 K+ channel (external)
catalog :
73-016
quantity :
5 ml
price :
269 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
K57/1
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, western blot knockout validation, immunohistochemistry knockout validation
more info or order :
citations: 65
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:500; loading ...; fig 1b
  • immunoprecipitation; rat; loading ...; fig 3a
  • immunocytochemistry; rat; 1:200; loading ...; fig s2
  • immunohistochemistry; rat; 1:500; loading ...; fig s1
  • western blot; rat; 1:1000; loading ...; fig 3a
Gupte R, Kadunganattil S, Shepherd A, Merrill R, Planer W, Bruchas M, et al. Convergent phosphomodulation of the major neuronal dendritic potassium channel Kv4.2 by pituitary adenylate cyclase-activating polypeptide. Neuropharmacology. 2016;101:291-308 pubmed publisher
Mulholland P, Spencer K, Hu W, Kroener S, Chandler L. Neuroplasticity of A-type potassium channel complexes induced by chronic alcohol exposure enhances dendritic calcium transients in hippocampus. Psychopharmacology (Berl). 2015;232:1995-2006 pubmed publisher
Lin L, Long L, Hatch M, Hoffman D. DPP6 domains responsible for its localization and function. J Biol Chem. 2014;289:32153-65 pubmed publisher
Jensen C, Misonou H. Live-cell imaging of post-golgi transport vesicles in cultured hippocampal neurons. Cell Mol Neurobiol. 2015;35:123-35 pubmed publisher
Lugo J, Smith G, Arbuckle E, White J, Holley A, Floruta C, et al. Deletion of PTEN produces autism-like behavioral deficits and alterations in synaptic proteins. Front Mol Neurosci. 2014;7:27 pubmed publisher
Dufour M, Woodhouse A, Goaillard J. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development. J Neurosci Res. 2014;92:981-99 pubmed publisher
Jensen C, Watanabe S, Rasmussen H, Schmitt N, Olesen S, Frost N, et al. Specific sorting and post-Golgi trafficking of dendritic potassium channels in living neurons. J Biol Chem. 2014;289:10566-81 pubmed publisher
Lopez Izquierdo A, Pereira R, Wende A, Punske B, Abel E, Tristani Firouzi M. The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization. Am J Physiol Heart Circ Physiol. 2014;306:H747-54 pubmed publisher
Mercer R, Ma L, Watts J, Strome R, Wohlgemuth S, Yang J, et al. The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6. J Biol Chem. 2013;288:37241-55 pubmed publisher
Rainnie D, Hazra R, Dabrowska J, Guo J, Li C, Dewitt S, et al. Distribution and functional expression of Kv4 family ? subunits and associated KChIP ? subunits in the bed nucleus of the stria terminalis. J Comp Neurol. 2014;522:609-25 pubmed publisher
Sack J, Stephanopoulos N, Austin D, Francis M, Trimmer J. Antibody-guided photoablation of voltage-gated potassium currents. J Gen Physiol. 2013;142:315-24 pubmed publisher
Sosanya N, Huang P, Cacheaux L, Chen C, Nguyen K, Perrone Bizzozero N, et al. Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1. J Cell Biol. 2013;202:53-69 pubmed publisher
Yao J, Sun J, Zhao Q, Wang C, Mei Y. Neuregulin-1/ErbB4 signaling regulates Kv4.2-mediated transient outward K+ current through the Akt/mTOR pathway. Am J Physiol Cell Physiol. 2013;305:C197-206 pubmed publisher
Brewster A, Lugo J, Patil V, Lee W, Qian Y, Vanegas F, et al. Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage. PLoS ONE. 2013;8:e57808 pubmed publisher
Yao J, Gao X, Chow C, Zhan X, Hu C, Mei Y. Neuritin activates insulin receptor pathway to up-regulate Kv4.2-mediated transient outward K+ current in rat cerebellar granule neurons. J Biol Chem. 2012;287:41534-45 pubmed publisher
Kim E, Hoffman D. Dynamic regulation of synaptic maturation state by voltage-gated A-type K+ channels in CA1 hippocampal pyramidal neurons. J Neurosci. 2012;32:14427-32 pubmed publisher
Kaufmann W, Matsui K, Jeromin A, Nerbonne J, Ferraguti F. Kv4.2 potassium channels segregate to extrasynaptic domains and influence intrasynaptic NMDA receptor NR2B subunit expression. Brain Struct Funct. 2013;218:1115-32 pubmed publisher
Xu D, Wu X, Grabauskas G, Owyang C. Butyrate-induced colonic hypersensitivity is mediated by mitogen-activated protein kinase activation in rat dorsal root ganglia. Gut. 2013;62:1466-74 pubmed publisher
Matsuyoshi H, Takimoto K, Yunoki T, Erickson V, Tyagi P, Hirao Y, et al. Distinct cellular distributions of Kv4 pore-forming and auxiliary subunits in rat dorsal root ganglion neurons. Life Sci. 2012;91:258-63 pubmed publisher
Manning C, Bundros A, Trimmer J. Benefits and pitfalls of secondary antibodies: why choosing the right secondary is of primary importance. PLoS ONE. 2012;7:e38313 pubmed publisher
Menegola M, Clark E, Trimmer J. The importance of immunohistochemical analyses in evaluating the phenotype of Kv channel knockout mice. Epilepsia. 2012;53 Suppl 1:142-9 pubmed publisher
Marionneau C, Carrasquillo Y, Norris A, Townsend R, Isom L, Link A, et al. The sodium channel accessory subunit Nav?1 regulates neuronal excitability through modulation of repolarizing voltage-gated K? channels. J Neurosci. 2012;32:5716-27 pubmed publisher
Foeger N, Norris A, Wren L, Nerbonne J. Augmentation of Kv4.2-encoded currents by accessory dipeptidyl peptidase 6 and 10 subunits reflects selective cell surface Kv4.2 protein stabilization. J Biol Chem. 2012;287:9640-50 pubmed publisher
Sethi J, Sanchez Alavez M, Tabarean I. Kv4.2 mediates histamine modulation of preoptic neuron activity and body temperature. PLoS ONE. 2011;6:e29134 pubmed publisher
Maity B, Stewart A, Yang J, Loo L, Sheff D, Shepherd A, et al. Regulator of G protein signaling 6 (RGS6) protein ensures coordination of motor movement by modulating GABAB receptor signaling. J Biol Chem. 2012;287:4972-81 pubmed publisher
Smith S, Xu L, Kasten M, Anderson M. Mutant LGI1 inhibits seizure-induced trafficking of Kv4.2 potassium channels. J Neurochem. 2012;120:611-21 pubmed publisher
Sun W, MAFFIE J, Lin L, Petralia R, Rudy B, Hoffman D. DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons. Neuron. 2011;71:1102-15 pubmed publisher
Wykes R, Kalmbach A, Eliava M, Waters J. Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice. Neurobiol Aging. 2012;33:1609-23 pubmed publisher
Grabauskas G, Heldsinger A, Wu X, Xu D, Zhou S, Owyang C. Diabetic visceral hypersensitivity is associated with activation of mitogen-activated kinase in rat dorsal root ganglia. Diabetes. 2011;60:1743-51 pubmed publisher
Cheng L, Yung A, Covarrubias M, Radice G. Cortactin is required for N-cadherin regulation of Kv1.5 channel function. J Biol Chem. 2011;286:20478-89 pubmed publisher
Gross C, Yao X, Pong D, Jeromin A, Bassell G. Fragile X mental retardation protein regulates protein expression and mRNA translation of the potassium channel Kv4.2. J Neurosci. 2011;31:5693-8 pubmed publisher
Guan D, Horton L, Armstrong W, FOEHRING R. Postnatal development of A-type and Kv1- and Kv2-mediated potassium channel currents in neocortical pyramidal neurons. J Neurophysiol. 2011;105:2976-88 pubmed publisher
Hu H, Gereau R. Metabotropic glutamate receptor 5 regulates excitability and Kv4.2-containing K? channels primarily in excitatory neurons of the spinal dorsal horn. J Neurophysiol. 2011;105:3010-21 pubmed publisher
Pruss H, Dewes M, Derst C, Fernández Klett F, Veh R, Priller J. Potassium channel expression in adult murine neural progenitor cells. Neuroscience. 2011;180:19-29 pubmed publisher
Lin L, Sun W, Kung F, Dell Acqua M, Hoffman D. AKAP79/150 impacts intrinsic excitability of hippocampal neurons through phospho-regulation of A-type K+ channel trafficking. J Neurosci. 2011;31:1323-32 pubmed publisher
Schwetz T, Norring S, Ednie A, Bennett E. Sialic acids attached to O-glycans modulate voltage-gated potassium channel gating. J Biol Chem. 2011;286:4123-32 pubmed publisher
Norris A, Foeger N, Nerbonne J. Interdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neurons. J Neurosci. 2010;30:13644-55 pubmed publisher
Dabrowska J, Rainnie D. Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala. Neuroscience. 2010;171:721-33 pubmed publisher
Foeger N, Marionneau C, Nerbonne J. Co-assembly of Kv4 {alpha} subunits with K+ channel-interacting protein 2 stabilizes protein expression and promotes surface retention of channel complexes. J Biol Chem. 2010;285:33413-22 pubmed publisher
Bealer S, Little J, Metcalf C, Brewster A, Anderson A. Autonomic and cellular mechanisms mediating detrimental cardiac effects of status epilepticus. Epilepsy Res. 2010;91:66-73 pubmed publisher
Min M, Wu Y, Shih P, Lu H, Wu Y, Hsu C, et al. Roles of A-type potassium currents in tuning spike frequency and integrating synaptic transmission in noradrenergic neurons of the A7 catecholamine cell group in rats. Neuroscience. 2010;168:633-45 pubmed publisher
Norris A, Nerbonne J. Molecular dissection of I(A) in cortical pyramidal neurons reveals three distinct components encoded by Kv4.2, Kv4.3, and Kv1.4 alpha-subunits. J Neurosci. 2010;30:5092-101 pubmed publisher
Lin L, Sun W, Wikenheiser A, Kung F, Hoffman D. KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation. Mol Cell Neurosci. 2010;43:315-25 pubmed publisher
Haberman R, Colantuoni C, Stocker A, Schmidt A, Pedersen J, Gallagher M. Prominent hippocampal CA3 gene expression profile in neurocognitive aging. Neurobiol Aging. 2011;32:1678-92 pubmed publisher
Mulholland P, Chandler L. Inhibition of glutamate transporters couples to Kv4.2 dephosphorylation through activation of extrasynaptic NMDA receptors. Neuroscience. 2010;165:130-7 pubmed publisher
Marionneau C, LeDuc R, Rohrs H, Link A, Townsend R, Nerbonne J. Proteomic analyses of native brain K(V)4.2 channel complexes. Channels (Austin). 2009;3:284-94 pubmed
Qu J, Mulo I, Myhr K. The development of Kv4.2 expression in the retina. Neurosci Lett. 2009;464:209-13 pubmed publisher
Phuket T, Covarrubias M. Kv4 Channels Underlie the Subthreshold-Operating A-type K-current in Nociceptive Dorsal Root Ganglion Neurons. Front Mol Neurosci. 2009;2:3 pubmed publisher
Aronica E, Boer K, Doorn K, Zurolo E, Spliet W, van Rijen P, et al. Expression and localization of voltage dependent potassium channel Kv4.2 in epilepsy associated focal lesions. Neurobiol Dis. 2009;36:81-95 pubmed publisher
Seikel E, Trimmer J. Convergent modulation of Kv4.2 channel alpha subunits by structurally distinct DPPX and KChIP auxiliary subunits. Biochemistry. 2009;48:5721-30 pubmed publisher
Lewis T, Mao T, Svoboda K, Arnold D. Myosin-dependent targeting of transmembrane proteins to neuronal dendrites. Nat Neurosci. 2009;12:568-76 pubmed publisher
Harvey M, Karolat J, Sakai Y, Sokolowski B. PPTX, a pentraxin domain-containing protein, interacts with the T1 domain of K v 4. J Neurosci Res. 2009;87:1841-7 pubmed publisher
Jung S, Kim J, Hoffman D. Rapid, bidirectional remodeling of synaptic NMDA receptor subunit composition by A-type K+ channel activity in hippocampal CA1 pyramidal neurons. Neuron. 2008;60:657-71 pubmed publisher
Klemmer P, Smit A, Li K. Proteomics analysis of immuno-precipitated synaptic protein complexes. J Proteomics. 2009;72:82-90 pubmed publisher
Day M, Wokosin D, Plotkin J, Tian X, Surmeier D. Differential excitability and modulation of striatal medium spiny neuron dendrites. J Neurosci. 2008;28:11603-14 pubmed publisher
Clark B, Kwon E, Maffie J, Jeong H, Nadal M, Strop P, et al. DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein. Front Mol Neurosci. 2008;1:8 pubmed publisher
Monaghan M, Menegola M, Vacher H, Rhodes K, Trimmer J. Altered expression and localization of hippocampal A-type potassium channel subunits in the pilocarpine-induced model of temporal lobe epilepsy. Neuroscience. 2008;156:550-62 pubmed publisher
Shin M, Brager D, JARAMILLO T, Johnston D, Chetkovich D. Mislocalization of h channel subunits underlies h channelopathy in temporal lobe epilepsy. Neurobiol Dis. 2008;32:26-36 pubmed publisher
Hammond R, Lin L, Sidorov M, Wikenheiser A, Hoffman D. Protein kinase a mediates activity-dependent Kv4.2 channel trafficking. J Neurosci. 2008;28:7513-9 pubmed publisher
Amarillo Y, De Santiago Castillo J, Dougherty K, Maffie J, Kwon E, Covarrubias M, et al. Ternary Kv4.2 channels recapitulate voltage-dependent inactivation kinetics of A-type K+ channels in cerebellar granule neurons. J Physiol. 2008;586:2093-106 pubmed publisher
Gardoni F, Mauceri D, Marcello E, Sala C, Di Luca M, Jeromin A. SAP97 directs the localization of Kv4.2 to spines in hippocampal neurons: regulation by CaMKII. J Biol Chem. 2007;282:28691-9 pubmed
Kim J, Jung S, Clemens A, Petralia R, Hoffman D. Regulation of dendritic excitability by activity-dependent trafficking of the A-type K+ channel subunit Kv4.2 in hippocampal neurons. Neuron. 2007;54:933-47 pubmed
Vacher H, Mohapatra D, Misonou H, Trimmer J. Regulation of Kv1 channel trafficking by the mamba snake neurotoxin dendrotoxin K. FASEB J. 2007;21:906-14 pubmed
Burkhalter A, Gonchar Y, Mellor R, Nerbonne J. Differential expression of I(A) channel subunits Kv4.2 and Kv4.3 in mouse visual cortical neurons and synapses. J Neurosci. 2006;26:12274-82 pubmed
Menegola M, Trimmer J. Unanticipated region- and cell-specific downregulation of individual KChIP auxiliary subunit isotypes in Kv4.2 knock-out mouse brain. J Neurosci. 2006;26:12137-42 pubmed
product information
TargetType :
K+ channels
Target :
Kv4.2 K+ channel (external)
AccessionNum :
Q9NZV8
Clone :
K57/1
HumanGeneName :
KCND2
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/K57_1.pdf
IsoType :
IgG1
ValidationT :
Pass
ValidationBrIB :
Pass
ValidationBrIHC :
Pass
ValidationKO :
Pass
Catalog :
73-016
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States