product summary
company name :
Neuromab
product type :
antibody
product name :
Kv1.1 K+ channel
catalog :
73-007
quantity :
5 ml
price :
269 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
K20/78
reactivity :
mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, western blot knockout validation
more info or order :
citations: 49
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; 1:250
King C, Lancaster E, Salomon D, Peles E, Scherer S. Kv7.2 regulates the function of peripheral sensory neurons. J Comp Neurol. 2014;522:3262-80 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:100
Huang C, Chu D, Hwang W, Tsaur M. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. J Comp Neurol. 2012;520:3650-72 pubmed publisher
Nguyen L, Anderson A. mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy. Sci Rep. 2018;8:3568 pubmed publisher
Kole M, Qian J, Waase M, Klassen T, Chen T, Augustine G, et al. Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing. J Neurosci. 2015;35:11433-44 pubmed publisher
Smith K, Browne L, Selwood D, McAlpine D, Jagger D. Phosphoinositide Modulation of Heteromeric Kv1 Channels Adjusts Output of Spiral Ganglion Neurons from Hearing Mice. J Neurosci. 2015;35:11221-32 pubmed publisher
Lee K, Royston S, Vest M, Ley D, Lee S, Bolton E, et al. N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity. Mol Brain. 2015;8:4 pubmed publisher
Qi Y, Wang J, Bomben V, Li D, Chen S, Sun H, et al. Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death. Neuron. 2014;83:1159-71 pubmed publisher
Tagoe T, Barker M, Jones A, Allcock N, Hamann M. Auditory nerve perinodal dysmyelination in noise-induced hearing loss. J Neurosci. 2014;34:2684-8 pubmed publisher
Kirchheim F, Tinnes S, Haas C, Stegen M, Wolfart J. Regulation of action potential delays via voltage-gated potassium Kv1.1 channels in dentate granule cells during hippocampal epilepsy. Front Cell Neurosci. 2013;7:248 pubmed publisher
Sosanya N, Huang P, Cacheaux L, Chen C, Nguyen K, Perrone Bizzozero N, et al. Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1. J Cell Biol. 2013;202:53-69 pubmed publisher
Zhao X, Tang Z, Zhang H, Atianjoh F, Zhao J, Liang L, et al. A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons. Nat Neurosci. 2013;16:1024-31 pubmed publisher
Lallet Daher H, Wiel C, Gitenay D, Navaratnam N, Augert A, Le Calve B, et al. Potassium channel KCNA1 modulates oncogene-induced senescence and transformation. Cancer Res. 2013;73:5253-65 pubmed publisher
Brewster A, Lugo J, Patil V, Lee W, Qian Y, Vanegas F, et al. Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage. PLoS ONE. 2013;8:e57808 pubmed publisher
Ovsepian S, Steuber V, Le Berre M, O Hara L, O Leary V, Dolly J. A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets. J Physiol. 2013;591:1771-91 pubmed publisher
Nguyen H, Miyazaki H, Hoshi N, Smith B, Nukina N, Goldin A, et al. Modulation of voltage-gated K+ channels by the sodium channel ?1 subunit. Proc Natl Acad Sci U S A. 2012;109:18577-82 pubmed publisher
Yao J, Gao X, Chow C, Zhan X, Hu C, Mei Y. Neuritin activates insulin receptor pathway to up-regulate Kv4.2-mediated transient outward K+ current in rat cerebellar granule neurons. J Biol Chem. 2012;287:41534-45 pubmed publisher
Engelhardt M, Vorwald S, Sobotzik J, Bennett V, Schultz C. Ankyrin-B structurally defines terminal microdomains of peripheral somatosensory axons. Brain Struct Funct. 2013;218:1005-16 pubmed publisher
Glasscock E, Qian J, Kole M, Noebels J. Transcompartmental reversal of single fibre hyperexcitability in juxtaparanodal Kv1.1-deficient vagus nerve axons by activation of nodal KCNQ channels. J Physiol. 2012;590:3913-26 pubmed publisher
Buttermore E, Piochon C, Wallace M, Philpot B, Hansel C, Bhat M. Pinceau organization in the cerebellum requires distinct functions of neurofascin in Purkinje and basket neurons during postnatal development. J Neurosci. 2012;32:4724-42 pubmed publisher
Huang Y, Ruiz C, Eyler E, Lin K, Meffert M. Dual regulation of miRNA biogenesis generates target specificity in neurotrophin-induced protein synthesis. Cell. 2012;148:933-46 pubmed publisher
Ivanovic A, Horresh I, Golan N, Spiegel I, Sabanay H, Frechter S, et al. The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves. J Cell Biol. 2012;196:337-44 pubmed publisher
Kaphzan H, Buffington S, Jung J, Rasband M, Klann E. Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome. J Neurosci. 2011;31:17637-48 pubmed publisher
Bildl W, Haupt A, Müller C, Biniossek M, Thumfart J, Hüber B, et al. Extending the dynamic range of label-free mass spectrometric quantification of affinity purifications. Mol Cell Proteomics. 2012;11:M111.007955 pubmed publisher
Duflocq A, Chareyre F, Giovannini M, Couraud F, Davenne M. Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B. BMC Biol. 2011;9:66 pubmed publisher
Sun W, MAFFIE J, Lin L, Petralia R, Rudy B, Hoffman D. DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons. Neuron. 2011;71:1102-15 pubmed publisher
Loukaides P, Schiza N, Pettingill P, Palazis L, Vounou E, Vincent A, et al. Morvan's syndrome associated with antibodies to multiple components of the voltage-gated potassium channel complex. J Neurol Sci. 2012;312:52-6 pubmed publisher
Lysakowski A, Gaboyard Niay S, Calin Jageman I, Chatlani S, Price S, Eatock R. Molecular microdomains in a sensory terminal, the vestibular calyx ending. J Neurosci. 2011;31:10101-14 pubmed publisher
Wykes R, Kalmbach A, Eliava M, Waters J. Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice. Neurobiol Aging. 2012;33:1609-23 pubmed publisher
Hirtz J, Boesen M, Braun N, Deitmer J, Kramer F, Lohr C, et al. Cav1.3 calcium channels are required for normal development of the auditory brainstem. J Neurosci. 2011;31:8280-94 pubmed publisher
Buttermore E, Dupree J, Cheng J, An X, Tessarollo L, Bhat M. The cytoskeletal adaptor protein band 4.1B is required for the maintenance of paranodal axoglial septate junctions in myelinated axons. J Neurosci. 2011;31:8013-24 pubmed publisher
Vacher H, Yang J, Cerda O, Autillo Touati A, Dargent B, Trimmer J. Cdk-mediated phosphorylation of the Kv?2 auxiliary subunit regulates Kv1 channel axonal targeting. J Cell Biol. 2011;192:813-24 pubmed publisher
Fulton S, Thibault D, Mendez J, Lahaie N, Tirotta E, Borrelli E, et al. Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow. J Biol Chem. 2011;286:9360-72 pubmed publisher
Giacomini C, La Padula V, Schenone A, Leandri M, Contestabile A, Moruzzo D, et al. Both Schwann cell and axonal defects cause motor peripheral neuropathy in Ebf2-/- mice. Neurobiol Dis. 2011;42:73-84 pubmed publisher
Large R, Hollywood M, Sergeant G, Thornbury K, Bourke S, Levick J, et al. Ionic currents in intimal cultured synoviocytes from the rabbit. Am J Physiol Cell Physiol. 2010;299:C1180-94 pubmed publisher
Lai M, Huijbers M, Lancaster E, Graus F, Bataller L, Balice Gordon R, et al. Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series. Lancet Neurol. 2010;9:776-85 pubmed publisher
Gazula V, Strumbos J, Mei X, Chen H, Rahner C, Kaczmarek L. Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons. J Comp Neurol. 2010;518:3205-20 pubmed publisher
Glasscock E, Yoo J, Chen T, Klassen T, Noebels J. Kv1.1 potassium channel deficiency reveals brain-driven cardiac dysfunction as a candidate mechanism for sudden unexplained death in epilepsy. J Neurosci. 2010;30:5167-75 pubmed publisher
Fukata Y, Lovero K, Iwanaga T, Watanabe A, Yokoi N, Tabuchi K, et al. Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy. Proc Natl Acad Sci U S A. 2010;107:3799-804 pubmed publisher
Ogawa Y, Oses Prieto J, Kim M, Horresh I, Peles E, Burlingame A, et al. ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons. J Neurosci. 2010;30:1038-48 pubmed publisher
van der Wijst J, Glaudemans B, Venselaar H, Nair A, Forst A, Hoenderop J, et al. Functional analysis of the Kv1.1 N255D mutation associated with autosomal dominant hypomagnesemia. J Biol Chem. 2010;285:171-8 pubmed publisher
Toyoshima M, Sakurai K, Shimazaki K, Takeda Y, Shimoda Y, Watanabe K. Deficiency of neural recognition molecule NB-2 affects the development of glutamatergic auditory pathways from the ventral cochlear nucleus to the superior olivary complex in mouse. Dev Biol. 2009;336:192-200 pubmed publisher
Glaudemans B, van der Wijst J, Scola R, Lorenzoni P, Heister A, van der Kemp A, et al. A missense mutation in the Kv1.1 voltage-gated potassium channel-encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia. J Clin Invest. 2009;119:936-42 pubmed publisher
Miller M, Okaty B, Nelson S. Region-specific spike-frequency acceleration in layer 5 pyramidal neurons mediated by Kv1 subunits. J Neurosci. 2008;28:13716-26 pubmed publisher
Cartwright T, Schwalbe R. Atypical sialylated N-glycan structures are attached to neuronal voltage-gated potassium channels. Biosci Rep. 2009;29:301-13 pubmed publisher
Pineda R, Knoeckel C, Taylor A, Estrada Bernal A, Ribera A. Kv1 potassium channel complexes in vivo require Kvbeta2 subunits in dorsal spinal neurons. J Neurophysiol. 2008;100:2125-36 pubmed publisher
Ogawa Y, Horresh I, Trimmer J, Bredt D, Peles E, Rasband M. Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2. J Neurosci. 2008;28:5731-9 pubmed publisher
Wenzel H, Vacher H, Clark E, Trimmer J, Lee A, Sapolsky R, et al. Structural consequences of Kcna1 gene deletion and transfer in the mouse hippocampus. Epilepsia. 2007;48:2023-46 pubmed
Vacher H, Mohapatra D, Misonou H, Trimmer J. Regulation of Kv1 channel trafficking by the mamba snake neurotoxin dendrotoxin K. FASEB J. 2007;21:906-14 pubmed
Gu C, Zhou W, Puthenveedu M, Xu M, Jan Y, Jan L. The microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targeting. Neuron. 2006;52:803-16 pubmed
product information
TargetType :
K+ channels
Target :
Kv1.1 K+ channel
AccessionNum :
P10499
Clone :
K20/78
HumanGeneName :
KCNA1
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/K20_78.pdf
IsoType :
IgG1
ValidationT :
Pass
ValidationBrIB :
Pass
ValidationBrIHC :
Pass
ValidationKO :
Pass
Catalog :
73-007
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States