product summary
company name :
Neuromab
product type :
antibody
product name :
KChIP2b K+ channel
catalog :
73-004
quantity :
5 ml
price :
269 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
K60/73
reactivity :
rat
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
citations: 43
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; rat; 1:500; fig 4
Isensee J, Wenzel C, Buschow R, Weissmann R, Kuss A, Hucho T. Subgroup-elimination transcriptomics identifies signaling proteins that define subclasses of TRPV1-positive neurons and a novel paracrine circuit. PLoS ONE. 2014;9:e115731 pubmed publisher
Zhang X, Ai X, Nakayama H, Chen B, Harris D, Tang M, et al. Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias. Basic Res Cardiol. 2016;111:4 pubmed publisher
Cheng C, Wang W, Huang C, Du P, Yang J, Tsaur M. Coexpression of auxiliary subunits KChIP and DPPL in potassium channel Kv4-positive nociceptors and pain-modulating spinal interneurons. J Comp Neurol. 2016;524:846-73 pubmed publisher
Liu W, Deng J, Wang G, Gao K, Lin Z, Liu S, et al. Manipulation of KCNE2 expression modulates action potential duration and Ito and IK in rat and mouse ventricular myocytes. Am J Physiol Heart Circ Physiol. 2015;309:H1288-302 pubmed publisher
El Gebeily G, El Khoury N, Mathieu S, Brouillette J, Fiset C. Estrogen regulation of the transient outward K(+) current involves estrogen receptor α in mouse heart. J Mol Cell Cardiol. 2015;86:85-94 pubmed publisher
You T, Mao W, Cai B, Li F, Xu H. Two novel Brugada syndrome-associated mutations increase KV4.3 membrane expression and function. Int J Mol Med. 2015;36:309-15 pubmed publisher
Lei Z, Zhang H, Liang Y, Cui Q, Xu Z, Xu Z. Reduced expression of IA channels is associated with postischemic seizures in hyperglycemic rats. J Neurosci Res. 2014;92:1775-84 pubmed publisher
Rudakova E, Wagner M, Frank M, Volk T. Localization of Kv4.2 and KChIP2 in lipid rafts and modulation of outward K+ currents by membrane cholesterol content in rat left ventricular myocytes. Pflugers Arch. 2015;467:299-309 pubmed publisher
Kant R, Hu Z, Malhotra J, Krogh Madsen T, Christini D, Heerdt P, et al. NHE isoform switching and KChIP2 upregulation in aging porcine atria. PLoS ONE. 2013;8:e82951 pubmed publisher
Lopez Izquierdo A, Pereira R, Wende A, Punske B, Abel E, Tristani Firouzi M. The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization. Am J Physiol Heart Circ Physiol. 2014;306:H747-54 pubmed publisher
Mercer R, Ma L, Watts J, Strome R, Wohlgemuth S, Yang J, et al. The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6. J Biol Chem. 2013;288:37241-55 pubmed publisher
Speerschneider T, Grubb S, Metoska A, Olesen S, Calloe K, Thomsen M. Development of heart failure is independent of K+ channel-interacting protein 2 expression. J Physiol. 2013;591:5923-37 pubmed publisher
Rainnie D, Hazra R, Dabrowska J, Guo J, Li C, Dewitt S, et al. Distribution and functional expression of Kv4 family ? subunits and associated KChIP ? subunits in the bed nucleus of the stria terminalis. J Comp Neurol. 2014;522:609-25 pubmed publisher
Foeger N, Wang W, Mellor R, Nerbonne J. Stabilization of Kv4 protein by the accessory K(+) channel interacting protein 2 (KChIP2) subunit is required for the generation of native myocardial fast transient outward K(+) currents. J Physiol. 2013;591:4149-66 pubmed publisher
Ozgen N, Lu Z, Boink G, Lau D, Shlapakova I, Bobkov Y, et al. Microtubules and angiotensin II receptors contribute to modulation of repolarization induced by ventricular pacing. Heart Rhythm. 2012;9:1865-72 pubmed publisher
Menegola M, Clark E, Trimmer J. The importance of immunohistochemical analyses in evaluating the phenotype of Kv channel knockout mice. Epilepsia. 2012;53 Suppl 1:142-9 pubmed publisher
Pruunsild P, Timmusk T. Subcellular localization and transcription regulatory potency of KCNIP/Calsenilin/DREAM/KChIP proteins in cultured primary cortical neurons do not provide support for their role in CRE-dependent gene expression. J Neurochem. 2012;123:29-43 pubmed publisher
Marionneau C, Carrasquillo Y, Norris A, Townsend R, Isom L, Link A, et al. The sodium channel accessory subunit Nav?1 regulates neuronal excitability through modulation of repolarizing voltage-gated K? channels. J Neurosci. 2012;32:5716-27 pubmed publisher
Suzuki T, Shioya T, Murayama T, Sugihara M, Odagiri F, Nakazato Y, et al. Multistep ion channel remodeling and lethal arrhythmia precede heart failure in a mouse model of inherited dilated cardiomyopathy. PLoS ONE. 2012;7:e35353 pubmed publisher
Jeyaraj D, Haldar S, Wan X, McCauley M, Ripperger J, Hu K, et al. Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature. 2012;483:96-9 pubmed publisher
Marshall G, Russell J, Tellez J, Jhund P, Currie S, Dempster J, et al. Remodelling of human atrial K+ currents but not ion channel expression by chronic ?-blockade. Pflugers Arch. 2012;463:537-48 pubmed publisher
Sun W, MAFFIE J, Lin L, Petralia R, Rudy B, Hoffman D. DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons. Neuron. 2011;71:1102-15 pubmed publisher
Stein A, Jones T, Herron T, Patel S, Day S, Noujaim S, et al. Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes. J Clin Invest. 2011;121:2641-50 pubmed publisher
Cheng L, Yung A, Covarrubias M, Radice G. Cortactin is required for N-cadherin regulation of Kv1.5 channel function. J Biol Chem. 2011;286:20478-89 pubmed publisher
Bourdeau M, Laplante I, Laurent C, Lacaille J. KChIP1 modulation of Kv4.3-mediated A-type K(+) currents and repetitive firing in hippocampal interneurons. Neuroscience. 2011;176:173-87 pubmed publisher
Yang K, Foeger N, Marionneau C, Jay P, McMullen J, Nerbonne J. Homeostatic regulation of electrical excitability in physiological cardiac hypertrophy. J Physiol. 2010;588:5015-32 pubmed publisher
Norris A, Foeger N, Nerbonne J. Interdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neurons. J Neurosci. 2010;30:13644-55 pubmed publisher
Dabrowska J, Rainnie D. Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala. Neuroscience. 2010;171:721-33 pubmed publisher
Foeger N, Marionneau C, Nerbonne J. Co-assembly of Kv4 {alpha} subunits with K+ channel-interacting protein 2 stabilizes protein expression and promotes surface retention of channel complexes. J Biol Chem. 2010;285:33413-22 pubmed publisher
Levy D, Cepaitis E, Wanderling S, Toth P, Archer S, Goldstein S. The membrane protein MiRP3 regulates Kv4.2 channels in a KChIP-dependent manner. J Physiol. 2010;588:2657-68 pubmed publisher
Liu W, Deng J, Xu J, Wang H, Yuan M, Liu N, et al. High-mobility group box 1 (HMGB1) downregulates cardiac transient outward potassium current (Ito) through downregulation of Kv4.2 and Kv4.3 channel transcripts and proteins. J Mol Cell Cardiol. 2010;49:438-48 pubmed publisher
Xu X, Jiang M, Wang Y, Smith T, Baumgarten C, Wood M, et al. Long-term fish oil supplementation induces cardiac electrical remodeling by changing channel protein expression in the rabbit model. PLoS ONE. 2010;5:e10140 pubmed publisher
Anderson D, Mehaffey W, Iftinca M, Rehak R, Engbers J, Hameed S, et al. Regulation of neuronal activity by Cav3-Kv4 channel signaling complexes. Nat Neurosci. 2010;13:333-7 pubmed publisher
Wagner M, Rudakova E, Schütz V, Frank M, Ehmke H, Volk T. Larger transient outward K(+) current and shorter action potential duration in Galpha(11) mutant mice. Pflugers Arch. 2010;459:607-18 pubmed publisher
Soltysinska E, Olesen S, Christ T, Wettwer E, Varro A, Grunnet M, et al. Transmural expression of ion channels and transporters in human nondiseased and end-stage failing hearts. Pflugers Arch. 2009;459:11-23 pubmed publisher
Calloe K, Soltysinska E, Jespersen T, Lundby A, Antzelevitch C, Olesen S, et al. Differential effects of the transient outward K(+) current activator NS5806 in the canine left ventricle. J Mol Cell Cardiol. 2010;48:191-200 pubmed publisher
Jiang M, Xu X, Wang Y, Toyoda F, Liu X, Zhang M, et al. Dynamic partnership between KCNQ1 and KCNE1 and influence on cardiac IKs current amplitude by KCNE2. J Biol Chem. 2009;284:16452-62 pubmed publisher
Alexander J, McDermott C, Tunur T, Rands V, Stelly C, Karhson D, et al. The role of calsenilin/DREAM/KChIP3 in contextual fear conditioning. Learn Mem. 2009;16:167-77 pubmed publisher
Monaghan M, Menegola M, Vacher H, Rhodes K, Trimmer J. Altered expression and localization of hippocampal A-type potassium channel subunits in the pilocarpine-induced model of temporal lobe epilepsy. Neuroscience. 2008;156:550-62 pubmed publisher
Marionneau C, Aimond F, Brunet S, Niwa N, Finck B, Kelly D, et al. PPARalpha-mediated remodeling of repolarizing voltage-gated K+ (Kv) channels in a mouse model of metabolic cardiomyopathy. J Mol Cell Cardiol. 2008;44:1002-15 pubmed publisher
Marionneau C, Brunet S, Flagg T, Pilgram T, Demolombe S, Nerbonne J. Distinct cellular and molecular mechanisms underlie functional remodeling of repolarizing K+ currents with left ventricular hypertrophy. Circ Res. 2008;102:1406-15 pubmed publisher
Niwa N, Wang W, Sha Q, Marionneau C, Nerbonne J. Kv4.3 is not required for the generation of functional Ito,f channels in adult mouse ventricles. J Mol Cell Cardiol. 2008;44:95-104 pubmed
Menegola M, Trimmer J. Unanticipated region- and cell-specific downregulation of individual KChIP auxiliary subunit isotypes in Kv4.2 knock-out mouse brain. J Neurosci. 2006;26:12137-42 pubmed
product information
TargetType :
K+ channels
Target :
KChIP2b K+ channel
AccessionNum :
AAF81756
Clone :
K60/73
HumanGeneName :
KCNIP2
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/K60_73.pdf
IsoType :
IgG1
ValidationT :
Pass
ValidationBrIB :
Pass
ValidationBrIHC :
Pass
ValidationKO :
ND
Catalog :
73-004
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States