product summary
company name :
Neuromab
product type :
antibody
product name :
GluA2/GluR2 glutamate receptor
catalog :
73-002
quantity :
5 ml
price :
319 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
L21/32
reactivity :
mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, western blot knockout validation
more info or order :
citations: 89
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; fig s6
Wang X, Bey A, Katz B, Badea A, Kim N, David L, et al. Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism. Nat Commun. 2016;7:11459 pubmed publisher
  • western blot; mouse; fig 7
Moraga Amaro R, González H, Ugalde V, Donoso Ramos J, Quintana Donoso D, Lara M, et al. Dopamine receptor D5 deficiency results in a selective reduction of hippocampal NMDA receptor subunit NR2B expression and impaired memory. Neuropharmacology. 2016;103:222-35 pubmed publisher
  • western blot; mouse; fig 5c
Tapia Rojas C, Lindsay C, Montecinos Oliva C, Arrázola M, Retamales R, Bunout D, et al. Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice. Mol Neurodegener. 2015;10:62 pubmed publisher
  • western blot; mouse; fig 3
Serrano F, Tapia Rojas C, Carvajal F, Hancke J, Cerpa W, Inestrosa N. Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice. Mol Neurodegener. 2014;9:61 pubmed publisher
  • western blot; rat; fig 1
Yan Y, Eipper B, Mains R. Kalirin-9 and Kalirin-12 Play Essential Roles in Dendritic Outgrowth and Branching. Cereb Cortex. 2015;25:3487-501 pubmed publisher
Zhang J, Guan X, Li Q, Meredith A, Pan H, Yan J. Glutamate-activated BK channel complexes formed with NMDA receptors. Proc Natl Acad Sci U S A. 2018;115:E9006-E9014 pubmed publisher
Wei J, Xiong Z, Lee J, Cheng J, Duffney L, Matas E, et al. Histone Modification of Nedd4 Ubiquitin Ligase Controls the Loss of AMPA Receptors and Cognitive Impairment Induced by Repeated Stress. J Neurosci. 2016;36:2119-30 pubmed publisher
Kirk L, Ti S, Bishop H, Orozco Llamas M, Pham M, Trimmer J, et al. Distribution of the SynDIG4/proline-rich transmembrane protein 1 in rat brain. J Comp Neurol. 2016;524:2266-80 pubmed publisher
Ghiglieri V, Mineo D, Vannelli A, Cacace F, Mancini M, Pendolino V, et al. Modulation of serotonergic transmission by eltoprazine in L-DOPA-induced dyskinesia: Behavioral, molecular, and synaptic mechanisms. Neurobiol Dis. 2016;86:140-53 pubmed publisher
Miyamoto T, Kim D, Knox J, Johnson E, Mucke L. Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity. J Biol Chem. 2016;291:1719-34 pubmed publisher
Lv J, Guo X, Chen B, Lei Q, Pan Y, Yang Q. The Noncompetitive AMPAR Antagonist Perampanel Abrogates Brain Endothelial Cell Permeability in Response to Ischemia: Involvement of Claudin-5. Cell Mol Neurobiol. 2016;36:745-53 pubmed publisher
Fourie C, Kim E, Waldvogel H, Wong J, McGregor A, Faull R, et al. Differential Changes in Postsynaptic Density Proteins in Postmortem Huntington's Disease and Parkinson's Disease Human Brains. J Neurodegener Dis. 2014;2014:938530 pubmed publisher
Zollinger D, Chang K, Baalman K, Kim S, Rasband M. The Polarity Protein Pals1 Regulates Radial Sorting of Axons. J Neurosci. 2015;35:10474-84 pubmed publisher
Pandey S, Singh H, Prasad S. Alterations in Hippocampal Oxidative Stress, Expression of AMPA Receptor GluR2 Subunit and Associated Spatial Memory Loss by Bacopa monnieri Extract (CDRI-08) in Streptozotocin-Induced Diabetes Mellitus Type 2 Mice. PLoS ONE. 2015;10:e0131862 pubmed publisher
Tindi J, Chávez A, Cvejic S, Calvo Ochoa E, Castillo P, Jordan B. ANKS1B Gene Product AIDA-1 Controls Hippocampal Synaptic Transmission by Regulating GluN2B Subunit Localization. J Neurosci. 2015;35:8986-96 pubmed publisher
Liu X, Xu S, Wang P, Wang W. Transient mitochondrial permeability transition mediates excitotoxicity in glutamate-sensitive NSC34D motor neuron-like cells. Exp Neurol. 2015;271:122-30 pubmed publisher
Varea O, Martín de Saavedra M, Kopeikina K, Schürmann B, Fleming H, Fawcett Patel J, et al. Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons. Proc Natl Acad Sci U S A. 2015;112:6176-81 pubmed publisher
Figueiro Silva J, Gruart A, Clayton K, Podlesniy P, Abad M, Gasull X, et al. Neuronal pentraxin 1 negatively regulates excitatory synapse density and synaptic plasticity. J Neurosci. 2015;35:5504-21 pubmed publisher
Riazi K, Galic M, Kentner A, Reid A, Sharkey K, Pittman Q. Microglia-dependent alteration of glutamatergic synaptic transmission and plasticity in the hippocampus during peripheral inflammation. J Neurosci. 2015;35:4942-52 pubmed publisher
Cristino L, Luongo L, Squillace M, Paolone G, Mango D, Piccinin S, et al. d-Aspartate oxidase influences glutamatergic system homeostasis in mammalian brain. Neurobiol Aging. 2015;36:1890-902 pubmed publisher
Chen N, Koopmans F, Gordon A, Paliukhovich I, Klaassen R, van der Schors R, et al. Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes. Biochim Biophys Acta. 2015;1854:827-33 pubmed publisher
D Orsi B, Kilbride S, Chen G, Perez Alvarez S, Bonner H, Pfeiffer S, et al. Bax regulates neuronal Ca2+ homeostasis. J Neurosci. 2015;35:1706-22 pubmed publisher
Pandey S, Rai R, Gaur P, Prasad S. Development- and age-related alterations in the expression of AMPA receptor subunit GluR2 and its trafficking proteins in the hippocampus of male mouse brain. Biogerontology. 2015;16:317-28 pubmed publisher
Neuner S, Wilmott L, Hope K, Hoffmann B, Chong J, Abramowitz J, et al. TRPC3 channels critically regulate hippocampal excitability and contextual fear memory. Behav Brain Res. 2015;281:69-77 pubmed publisher
Warmus B, Sekar D, McCutchen E, Schellenberg G, Roberts R, McMahon L, et al. Tau-mediated NMDA receptor impairment underlies dysfunction of a selectively vulnerable network in a mouse model of frontotemporal dementia. J Neurosci. 2014;34:16482-95 pubmed publisher
de Andrade G, Kunzelman L, Merrill M, Fuerst P. Developmentally dynamic colocalization patterns of DSCAM with adhesion and synaptic proteins in the mouse retina. Mol Vis. 2014;20:1422-33 pubmed
Prendergast J, Umanah G, Yoo S, Lagerlöf O, Motari M, Cole R, et al. Ganglioside regulation of AMPA receptor trafficking. J Neurosci. 2014;34:13246-58 pubmed publisher
Priya A, Johar K, Nair B, Wong Riley M. Nuclear respiratory factor 2 regulates the transcription of AMPA receptor subunit GluA2 (Gria2). Biochim Biophys Acta. 2014;1843:3018-28 pubmed publisher
Schwenk J, Baehrens D, Haupt A, Bildl W, Boudkkazi S, Roeper J, et al. Regional diversity and developmental dynamics of the AMPA-receptor proteome in the mammalian brain. Neuron. 2014;84:41-54 pubmed publisher
Bhattacharyya M, Battacharya M, Nandanoor A, Osman M, Kasinathan C, FREDERIKSE P. NMDA glutamate receptor NR1, NR2A and NR2B expression and NR2B Tyr-1472 phosphorylation in the lens. Neurochem Res. 2014;39:1825-32 pubmed publisher
Sun X, Pinacho R, Saia G, Punko D, Meana J, Ramos B, et al. Transcription factor Sp4 regulates expression of nervous wreck 2 to control NMDAR1 levels and dendrite patterning. Dev Neurobiol. 2015;75:93-108 pubmed publisher
Boudkkazi S, Brechet A, Schwenk J, Fakler B. Cornichon2 dictates the time course of excitatory transmission at individual hippocampal synapses. Neuron. 2014;82:848-58 pubmed publisher
Lu W, Khatri L, Ziff E. Trafficking of ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA) receptor subunit GluA2 from the endoplasmic reticulum is stimulated by a complex containing Ca2+/calmodulin-activated kinase II (CaMKII) and PICK1 protein and by rele. J Biol Chem. 2014;289:19218-30 pubmed publisher
Gong K, Kung L, Magni G, Bhargava A, Jasmin L. Increased response to glutamate in small diameter dorsal root ganglion neurons after sciatic nerve injury. PLoS ONE. 2014;9:e95491 pubmed publisher
Lussier M, Gu X, Lu W, Roche K. Casein kinase 2 phosphorylates GluA1 and regulates its surface expression. Eur J Neurosci. 2014;39:1148-58 pubmed publisher
Priya A, Johar K, Nair B, Wong Riley M. Specificity protein 4 (Sp4) regulates the transcription of AMPA receptor subunit GluA2 (Gria2). Biochim Biophys Acta. 2014;1843:1196-206 pubmed publisher
Li Q, Zheng S, Han A, Lin C, Stoilov P, Fu X, et al. The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. elife. 2014;3:e01201 pubmed publisher
Parkhurst C, Yang G, Ninan I, Savas J, Yates J, Lafaille J, et al. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell. 2013;155:1596-609 pubmed publisher
Song J, Dibattista A, Sung Y, Ahn J, Turner R, Yang J, et al. A tetra(ethylene glycol) derivative of benzothiazole aniline ameliorates dendritic spine density and cognitive function in a mouse model of Alzheimer's disease. Exp Neurol. 2014;252:105-13 pubmed publisher
Plaza Zabala A, Li X, Milovanovic M, Loweth J, Maldonado R, Berrendero F, et al. An investigation of interactions between hypocretin/orexin signaling and glutamate receptor surface expression in the rat nucleus accumbens under basal conditions and after cocaine exposure. Neurosci Lett. 2013;557 Pt B:101-6 pubmed publisher
Rylander D, Bagetta V, Pendolino V, Zianni E, Grealish S, Gardoni F, et al. Region-specific restoration of striatal synaptic plasticity by dopamine grafts in experimental parkinsonism. Proc Natl Acad Sci U S A. 2013;110:E4375-84 pubmed publisher
Han K, Holder J, Schaaf C, Lu H, Chen H, Kang H, et al. SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature. 2013;503:72-7 pubmed publisher
Luo P, Yang Y, Liu W, Rao W, Bian H, Li X, et al. Downregulation of postsynaptic density-95-interacting regulator of spine morphogenesis reduces glutamate-induced excitotoxicity by differentially regulating glutamate receptors in rat cortical neurons. FEBS J. 2013;280:6114-27 pubmed publisher
Breiderhoff T, Christiansen G, Pallesen L, Vaegter C, Nykjaer A, Holm M, et al. Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction. PLoS ONE. 2013;8:e75006 pubmed publisher
Krüger J, Favaro P, Liu M, Kitlinska A, Huang X, Raabe M, et al. Differential roles of postsynaptic density-93 isoforms in regulating synaptic transmission. J Neurosci. 2013;33:15504-17 pubmed publisher
Viviani B, Boraso M, Valero M, Gardoni F, Marco E, Llorente R, et al. Early maternal deprivation immunologically primes hippocampal synapses by redistributing interleukin-1 receptor type I in a sex dependent manner. Brain Behav Immun. 2014;35:135-43 pubmed publisher
Selvakumar B, Campbell P, Milovanovic M, Park D, West A, Snyder S, et al. AMPA receptor upregulation in the nucleus accumbens shell of cocaine-sensitized rats depends upon S-nitrosylation of stargazin. Neuropharmacology. 2014;77:28-38 pubmed publisher
Kintz N, Petzinger G, Akopian G, Ptasnik S, Williams C, Jakowec M, et al. Exercise modifies ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor expression in striatopallidal neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse. J Neurosci Res. 2013;91:1492-507 pubmed publisher
Siddoway B, Altimimi H, Hou H, Petralia R, Xu B, Stellwagen D, et al. An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. J Neurosci. 2013;33:11206-11 pubmed publisher
Wang X, Cahill M, Werner C, Christoffel D, Golden S, Xie Z, et al. Kalirin-7 mediates cocaine-induced AMPA receptor and spine plasticity, enabling incentive sensitization. J Neurosci. 2013;33:11012-22 pubmed publisher
Scheuss V, Bonhoeffer T. Function of dendritic spines on hippocampal inhibitory neurons. Cereb Cortex. 2014;24:3142-53 pubmed publisher
Kuzirian M, Moore A, Staudenmaier E, Friedel R, Paradis S. The class 4 semaphorin Sema4D promotes the rapid assembly of GABAergic synapses in rodent hippocampus. J Neurosci. 2013;33:8961-73 pubmed publisher
Barak B, Okun E, Ben Simon Y, Lavi A, Shapira R, Madar R, et al. Neuron-specific expression of tomosyn1 in the mouse hippocampal dentate gyrus impairs spatial learning and memory. Neuromolecular Med. 2013;15:351-63 pubmed publisher
Murata Y, Constantine Paton M. Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway. J Neurosci. 2013;33:5040-52 pubmed publisher
Mauric V, Mölders A, Harmel N, Heimrich B, Sergeeva O, Klocker N. Ontogeny repeats the phylogenetic recruitment of the cargo exporter cornichon into AMPA receptor signaling complexes. Mol Cell Neurosci. 2013;56:10-7 pubmed publisher
Li X, DeJoseph M, Urban J, Bahi A, Dreyer J, Meredith G, et al. Different roles of BDNF in nucleus accumbens core versus shell during the incubation of cue-induced cocaine craving and its long-term maintenance. J Neurosci. 2013;33:1130-42 pubmed publisher
Di Filippo M, Chiasserini D, Gardoni F, Viviani B, Tozzi A, Giampà C, et al. Effects of central and peripheral inflammation on hippocampal synaptic plasticity. Neurobiol Dis. 2013;52:229-36 pubmed publisher
Bagetta V, Sgobio C, Pendolino V, Del Papa G, Tozzi A, Ghiglieri V, et al. Rebalance of striatal NMDA/AMPA receptor ratio underlies the reduced emergence of dyskinesia during D2-like dopamine agonist treatment in experimental Parkinson's disease. J Neurosci. 2012;32:17921-31 pubmed publisher
Harraz M, Eacker S, Wang X, Dawson T, Dawson V. MicroRNA-223 is neuroprotective by targeting glutamate receptors. Proc Natl Acad Sci U S A. 2012;109:18962-7 pubmed publisher
Inestrosa N, Carvajal F, Zolezzi J, Tapia Rojas C, Serrano F, Karmelic D, et al. Peroxisome proliferators reduce spatial memory impairment, synaptic failure, and neurodegeneration in brains of a double transgenic mice model of Alzheimer's disease. J Alzheimers Dis. 2013;33:941-59 pubmed publisher
Watt N, Taylor D, Kerrigan T, Griffiths H, Rushworth J, Whitehouse I, et al. Prion protein facilitates uptake of zinc into neuronal cells. Nat Commun. 2012;3:1134 pubmed publisher
Ardiles A, Tapia Rojas C, Mandal M, Alexandre F, Kirkwood A, Inestrosa N, et al. Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2012;109:13835-40 pubmed publisher
Schwenk J, Harmel N, Brechet A, Zolles G, Berkefeld H, Müller C, et al. High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Neuron. 2012;74:621-33 pubmed publisher
Henderson A, Pittman Q, Teskey G. High frequency stimulation alters motor maps, impairs skilled reaching performance and is accompanied by an upregulation of specific GABA, glutamate and NMDA receptor subunits. Neuroscience. 2012;215:98-113 pubmed publisher
Boudreau A, Milovanovic M, CONRAD K, Nelson C, Ferrario C, Wolf M. A protein cross-linking assay for measuring cell surface expression of glutamate receptor subunits in the rodent brain after in vivo treatments. Curr Protoc Neurosci. 2012;Chapter 5:Unit 5.30.1-19 pubmed publisher
Reid A, Pittman Q, Teskey G. A prolonged experimental febrile seizure results in motor map reorganization in adulthood. Neurobiol Dis. 2012;45:692-700 pubmed publisher
Peng X, Kim J, Zhou Z, Fink D, Mata M. Neuronal Nogo-A regulates glutamate receptor subunit expression in hippocampal neurons. J Neurochem. 2011;119:1183-93 pubmed publisher
Rao Ruiz P, Rotaru D, van der Loo R, Mansvelder H, Stiedl O, Smit A, et al. Retrieval-specific endocytosis of GluA2-AMPARs underlies adaptive reconsolidation of contextual fear. Nat Neurosci. 2011;14:1302-8 pubmed publisher
Verpelli C, Dvoretskova E, Vicidomini C, Rossi F, Chiappalone M, Schoen M, et al. Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J Biol Chem. 2011;286:34839-50 pubmed publisher
Li X, Wolf M. Brain-derived neurotrophic factor rapidly increases AMPA receptor surface expression in rat nucleus accumbens. Eur J Neurosci. 2011;34:190-8 pubmed publisher
Ferrario C, Loweth J, Milovanovic M, Ford K, Galiñanes G, Heng L, et al. Alterations in AMPA receptor subunits and TARPs in the rat nucleus accumbens related to the formation of Ca²?-permeable AMPA receptors during the incubation of cocaine craving. Neuropharmacology. 2011;61:1141-51 pubmed publisher
Brown M, Bellone C, Mameli M, Labouèbe G, Bocklisch C, Balland B, et al. Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulation. PLoS ONE. 2010;5:e15870 pubmed publisher
Ferrario C, Loweth J, Milovanovic M, Wang X, Wolf M. Distribution of AMPA receptor subunits and TARPs in synaptic and extrasynaptic membranes of the adult rat nucleus accumbens. Neurosci Lett. 2011;490:180-4 pubmed publisher
Giza J, Urbanski M, Prestori F, Bandyopadhyay B, Yam A, Friedrich V, et al. Behavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet brain-2. J Neurosci. 2010;30:14805-16 pubmed publisher
Epis R, Marcello E, Gardoni F, Vastagh C, Malinverno M, Balducci C, et al. Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease. Brain. 2010;133:3323-35 pubmed publisher
Antion M, Christie L, Bond A, Dalva M, Contractor A. Ephrin-B3 regulates glutamate receptor signaling at hippocampal synapses. Mol Cell Neurosci. 2010;45:378-88 pubmed publisher
Cubelos B, Sebastián Serrano A, Beccari L, Calcagnotto M, Cisneros E, Kim S, et al. Cux1 and Cux2 regulate dendritic branching, spine morphology, and synapses of the upper layer neurons of the cortex. Neuron. 2010;66:523-35 pubmed publisher
Verpelli C, Piccoli G, Zibetti C, Zanchi A, Gardoni F, Huang K, et al. Synaptic activity controls dendritic spine morphology by modulating eEF2-dependent BDNF synthesis. J Neurosci. 2010;30:5830-42 pubmed publisher
Westerholz S, de Lima A, Voigt T. Regulation of early spontaneous network activity and GABAergic neurons development by thyroid hormone. Neuroscience. 2010;168:573-89 pubmed publisher
Filiou M, Bisle B, Reckow S, Teplytska L, Maccarrone G, Turck C. Profiling of mouse synaptosome proteome and phosphoproteome by IEF. Electrophoresis. 2010;31:1294-301 pubmed publisher
Troca Marín J, Alves Sampaio A, Tejedor F, Montesinos M. Local translation of dendritic RhoA revealed by an improved synaptoneurosome preparation. Mol Cell Neurosci. 2010;43:308-14 pubmed publisher
VanLeeuwen J, Petzinger G, Walsh J, Akopian G, Vuckovic M, Jakowec M. Altered AMPA receptor expression with treadmill exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury. J Neurosci Res. 2010;88:650-68 pubmed publisher
Fumagalli F, Pasini M, Frasca A, Drago F, Racagni G, Riva M. Prenatal stress alters glutamatergic system responsiveness in adult rat prefrontal cortex. J Neurochem. 2009;109:1733-44 pubmed publisher
Gardoni F, Mauceri D, Malinverno M, Polli F, Costa C, Tozzi A, et al. Decreased NR2B subunit synaptic levels cause impaired long-term potentiation but not long-term depression. J Neurosci. 2009;29:669-77 pubmed publisher
Ghasemzadeh M, Vasudevan P, Mueller C. Locomotor sensitization to cocaine is associated with distinct pattern of glutamate receptor trafficking to the postsynaptic density in prefrontal cortex: early versus late withdrawal effects. Pharmacol Biochem Behav. 2009;92:383-92 pubmed publisher
Oberlander J, Lin A, Man H, Erskine M. AMPA receptors in the medial amygdala are critical for establishing a neuroendocrine memory in the female rat. Eur J Neurosci. 2009;29:146-60 pubmed publisher
Ghasemzadeh M, Mueller C, Vasudevan P. Behavioral sensitization to cocaine is associated with increased glutamate receptor trafficking to the postsynaptic density after extended withdrawal period. Neuroscience. 2009;159:414-26 pubmed publisher
Klemmer P, Smit A, Li K. Proteomics analysis of immuno-precipitated synaptic protein complexes. J Proteomics. 2009;72:82-90 pubmed publisher
Mameli M, Balland B, Lujan R, Lüscher C. Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area. Science. 2007;317:530-3 pubmed
product information
TargetType :
Receptors
Target :
GluA2/GluR2 glutamate receptor
AccessionNum :
P19491
Clone :
L21/32
HumanGeneName :
GRIA2
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/L21_32.pdf
IsoType :
IgG1
ValidationT :
Pass
ValidationBrIB :
Pass
ValidationBrIHC :
Pass
ValidationKO :
Pass
Catalog :
73-002
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States