product summary
company name :
Neuromab
product type :
antibody
product name :
CASPR/Neurexin IV
catalog :
73-001
quantity :
5 ml
price :
319 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
K65/35
reactivity :
mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section
more info or order :
citations: 76
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; loading ...; fig 4c
Browne L, Smith K, Jagger D. Identification of Persistent and Resurgent Sodium Currents in Spiral Ganglion Neurons Cultured from the Mouse Cochlea. Eneuro. 2017;4: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:50; loading ...; fig 4a
Serwanski D, Jukkola P, Nishiyama A. Heterogeneity of astrocyte and NG2 cell insertion at the node of ranvier. J Comp Neurol. 2017;525:535-552 pubmed publisher
  • immunohistochemistry; mouse; fig 1
Ho T, Zollinger D, Chang K, Xu M, Cooper E, Stankewich M, et al. A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier. Nat Neurosci. 2014;17:1664-72 pubmed publisher
  • immunocytochemistry; mouse; fig 1
Chang K, Zollinger D, Susuki K, Sherman D, Makara M, Brophy P, et al. Glial ankyrins facilitate paranodal axoglial junction assembly. Nat Neurosci. 2014;17:1673-81 pubmed publisher
  • immunohistochemistry; mouse; 1:100
Viganò F, Mobius W, Gotz M, Dimou L. Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain. Nat Neurosci. 2013;16:1370-2 pubmed publisher
Qin C, Liu Q, Hu Z, Zhou L, Shang K, Bosco D, et al. Microglial TLR4-dependent autophagy induces ischemic white matter damage via STAT1/6 pathway. Theranostics. 2018;8:5434-5451 pubmed publisher
Kaczmarek Hájek K, Zhang J, Kopp R, Grosche A, Rissiek B, Saul A, et al. Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody. elife. 2018;7: pubmed publisher
Huang C, Zhang C, Zollinger D, Leterrier C, Rasband M. An αII Spectrin-Based Cytoskeleton Protects Large-Diameter Myelinated Axons from Degeneration. J Neurosci. 2017;37:11323-11334 pubmed publisher
Davidson N, Yu F, Kijpaisalratana N, Le T, Beer L, Radomski K, et al. Leukemia/lymphoma-related factor (LRF) exhibits stage- and context-dependent transcriptional controls in the oligodendrocyte lineage and modulates remyelination. J Neurosci Res. 2017;95:2391-2408 pubmed publisher
Kim K, Rutherford M. Maturation of NaV and KV Channel Topographies in the Auditory Nerve Spike Initiator before and after Developmental Onset of Hearing Function. J Neurosci. 2016;36:2111-8 pubmed publisher
Kawabata S, Takano M, Numasawa Kuroiwa Y, Itakura G, Kobayashi Y, Nishiyama Y, et al. Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury. Stem Cell Reports. 2016;6:1-8 pubmed publisher
Seidl A, Rubel E. Systematic and differential myelination of axon collaterals in the mammalian auditory brainstem. Glia. 2016;64:487-94 pubmed publisher
Brügger V, Engler S, Pereira J, Ruff S, Horn M, Welzl H, et al. HDAC1/2-Dependent P0 Expression Maintains Paranodal and Nodal Integrity Independently of Myelin Stability through Interactions with Neurofascins. PLoS Biol. 2015;13:e1002258 pubmed publisher
Zollinger D, Chang K, Baalman K, Kim S, Rasband M. The Polarity Protein Pals1 Regulates Radial Sorting of Axons. J Neurosci. 2015;35:10474-84 pubmed publisher
Hirono M, Ogawa Y, Misono K, Zollinger D, Trimmer J, Rasband M, et al. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells. J Neurosci. 2015;35:7082-94 pubmed publisher
D Este E, Kamin D, Göttfert F, El Hady A, Hell S. STED nanoscopy reveals the ubiquity of subcortical cytoskeleton periodicity in living neurons. Cell Rep. 2015;10:1246-51 pubmed publisher
Chen N, Koopmans F, Gordon A, Paliukhovich I, Klaassen R, van der Schors R, et al. Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes. Biochim Biophys Acta. 2015;1854:827-33 pubmed publisher
Hinman J, Lee M, Tung S, Vinters H, Carmichael S. Molecular disorganization of axons adjacent to human lacunar infarcts. Brain. 2015;138:736-45 pubmed publisher
Jenkins P, Kim N, Jones S, Tseng W, Svitkina T, Yin H, et al. Giant ankyrin-G: a critical innovation in vertebrate evolution of fast and integrated neuronal signaling. Proc Natl Acad Sci U S A. 2015;112:957-64 pubmed publisher
Miyazaki H, Oyama F, Inoue R, Aosaki T, Abe T, Kiyonari H, et al. Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum. Nat Commun. 2014;5:5525 pubmed publisher
Trimarco A, Forese M, Alfieri V, Lucente A, Brambilla P, Dina G, et al. Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination. Nat Neurosci. 2014;17:1682-92 pubmed publisher
Xing Y, Röth P, Stratton J, Chuang B, Danne J, Ellis S, et al. Adult neural precursor cells from the subventricular zone contribute significantly to oligodendrocyte regeneration and remyelination. J Neurosci. 2014;34:14128-46 pubmed publisher
Tian C, Wang K, Ke W, Guo H, Shu Y. Molecular identity of axonal sodium channels in human cortical pyramidal cells. Front Cell Neurosci. 2014;8:297 pubmed publisher
Salewski R, Mitchell R, Shen C, Fehlings M. Transplantation of neural stem cells clonally derived from embryonic stem cells promotes recovery after murine spinal cord injury. Stem Cells Dev. 2015;24:36-50 pubmed publisher
Bull S, Bin J, Beaumont E, Boutet A, Krimpenfort P, Sadikot A, et al. Progressive disorganization of paranodal junctions and compact myelin due to loss of DCC expression by oligodendrocytes. J Neurosci. 2014;34:9768-78 pubmed publisher
Yamada J, Jinno S. Age-related differences in oligodendrogenesis across the dorsal-ventral axis of the mouse hippocampus. Hippocampus. 2014;24:1017-29 pubmed publisher
Leinders M, Koehrn F, Bartok B, Boyle D, Shubayev V, Kalcheva I, et al. Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: potential roles in acute inflammatory pain. Pain. 2014;155:1150-60 pubmed publisher
Battefeld A, Tran B, Gavrilis J, Cooper E, Kole M. Heteromeric Kv7.2/7.3 channels differentially regulate action potential initiation and conduction in neocortical myelinated axons. J Neurosci. 2014;34:3719-32 pubmed publisher
Yao D, McGonigal R, Barrie J, Cappell J, Cunningham M, Meehan G, et al. Neuronal expression of GalNAc transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice. J Neurosci. 2014;34:880-91 pubmed publisher
Dagley L, White C, Liao Y, Shi W, Smyth G, Orian J, et al. Quantitative proteomic profiling reveals novel region-specific markers in the adult mouse brain. Proteomics. 2014;14:241-61 pubmed publisher
Koehler K, Mikosz A, Molosh A, Patel D, Hashino E. Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture. Nature. 2013;500:217-21 pubmed publisher
Liu R, Lin G, Xu H. An efficient method for dorsal root ganglia neurons purification with a one-time anti-mitotic reagent treatment. PLoS ONE. 2013;8:e60558 pubmed publisher
Petrosyan H, Hunanyan A, Alessi V, Schnell L, Levine J, Arvanian V. Neutralization of inhibitory molecule NG2 improves synaptic transmission, retrograde transport, and locomotor function after spinal cord injury in adult rats. J Neurosci. 2013;33:4032-43 pubmed publisher
Kondo Y, Ramaker J, Radcliff A, Baldassari S, Mayer J, Ver Hoeve J, et al. Spontaneous optic nerve compression in the osteopetrotic (op/op) mouse: a novel model of myelination failure. J Neurosci. 2013;33:3514-25 pubmed publisher
Chen C, Sloane J, Li H, Aytan N, Giannaris E, Zeldich E, et al. The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS. J Neurosci. 2013;33:1927-39 pubmed publisher
Takano M, Hikishima K, Fujiyoshi K, Shibata S, Yasuda A, Konomi T, et al. MRI characterization of paranodal junction failure and related spinal cord changes in mice. PLoS ONE. 2012;7:e52904 pubmed publisher
Horn K, Glasgow S, Gobert D, Bull S, Luk T, Girgis J, et al. DCC expression by neurons regulates synaptic plasticity in the adult brain. Cell Rep. 2013;3:173-85 pubmed publisher
Brambrink A, Back S, Riddle A, Gong X, Moravec M, Dissen G, et al. Isoflurane-induced apoptosis of oligodendrocytes in the neonatal primate brain. Ann Neurol. 2012;72:525-35 pubmed publisher
Bin J, Leong S, Bull S, Antel J, Kennedy T. Oligodendrocyte precursor cell transplantation into organotypic cerebellar shiverer slices: a model to study myelination and myelin maintenance. PLoS ONE. 2012;7:e41237 pubmed publisher
Engelhardt M, Vorwald S, Sobotzik J, Bennett V, Schultz C. Ankyrin-B structurally defines terminal microdomains of peripheral somatosensory axons. Brain Struct Funct. 2013;218:1005-16 pubmed publisher
Manning C, Bundros A, Trimmer J. Benefits and pitfalls of secondary antibodies: why choosing the right secondary is of primary importance. PLoS ONE. 2012;7:e38313 pubmed publisher
Gasser A, Ho T, Cheng X, Chang K, Waxman S, Rasband M, et al. An ankyrinG-binding motif is necessary and sufficient for targeting Nav1.6 sodium channels to axon initial segments and nodes of Ranvier. J Neurosci. 2012;32:7232-43 pubmed publisher
Bangratz M, Sarrazin N, Devaux J, Zambroni D, Echaniz Laguna A, Rene F, et al. A mouse model of Schwartz-Jampel syndrome reveals myelinating Schwann cell dysfunction with persistent axonal depolarization in vitro and distal peripheral nerve hyperexcitability when perlecan is lacking. Am J Pathol. 2012;180:2040-55 pubmed publisher
Liazoghli D, Roth A, Thostrup P, Colman D. Substrate Micropatterning as a New in Vitro Cell Culture System to Study Myelination. ACS Chem Neurosci. 2012;3:90-95 pubmed
Reimer M, McQueen J, Searcy L, Scullion G, Zonta B, Desmazieres A, et al. Rapid disruption of axon-glial integrity in response to mild cerebral hypoperfusion. J Neurosci. 2011;31:18185-94 pubmed publisher
Sun W, Fu Y, Shi Y, Cheng J, Cao P, Shi R. Paranodal myelin damage after acute stretch in Guinea pig spinal cord. J Neurotrauma. 2012;29:611-9 pubmed publisher
Duflocq A, Chareyre F, Giovannini M, Couraud F, Davenne M. Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B. BMC Biol. 2011;9:66 pubmed publisher
Roza C, Castillejo S, Lopez Garcia J. Accumulation of Kv7.2 channels in putative ectopic transduction zones of mice nerve-end neuromas. Mol Pain. 2011;7:58 pubmed publisher
Lysakowski A, Gaboyard Niay S, Calin Jageman I, Chatlani S, Price S, Eatock R. Molecular microdomains in a sensory terminal, the vestibular calyx ending. J Neurosci. 2011;31:10101-14 pubmed publisher
Huff T, Shi Y, Sun W, Wu W, Shi R, Cheng J. Real-time CARS imaging reveals a calpain-dependent pathway for paranodal myelin retraction during high-frequency stimulation. PLoS ONE. 2011;6:e17176 pubmed publisher
Shi Y, Sun W, McBride J, Cheng J, Shi R. Acrolein induces myelin damage in mammalian spinal cord. J Neurochem. 2011;117:554-64 pubmed publisher
Pohl H, Porcheri C, Mueggler T, Bachmann L, Martino G, Riethmacher D, et al. Genetically induced adult oligodendrocyte cell death is associated with poor myelin clearance, reduced remyelination, and axonal damage. J Neurosci. 2011;31:1069-80 pubmed publisher
Hunanyan A, Alessi V, Patel S, Pearse D, Matthews G, Arvanian V. Alterations of action potentials and the localization of Nav1.6 sodium channels in spared axons after hemisection injury of the spinal cord in adult rats. J Neurophysiol. 2011;105:1033-44 pubmed publisher
Chang K, Susuki K, Dours Zimmermann M, Zimmermann D, Rasband M. Oligodendrocyte myelin glycoprotein does not influence node of ranvier structure or assembly. J Neurosci. 2010;30:14476-81 pubmed publisher
Crawford D, Mangiardi M, Song B, Patel R, Du S, Sofroniew M, et al. Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelination. Brain. 2010;133:2999-3016 pubmed publisher
Howell O, Rundle J, Garg A, Komada M, Brophy P, Reynolds R. Activated microglia mediate axoglial disruption that contributes to axonal injury in multiple sclerosis. J Neuropathol Exp Neurol. 2010;69:1017-1033 pubmed publisher
Luo S, Perry G, Levinson S, Henry M. Pulpitis increases the proportion of atypical nodes of Ranvier in human dental pulp axons without a change in Nav1.6 sodium channel expression. Neuroscience. 2010;169:1881-7 pubmed publisher
Hunanyan A, Garcia Alias G, Alessi V, Levine J, Fawcett J, Mendell L, et al. Role of chondroitin sulfate proteoglycans in axonal conduction in Mammalian spinal cord. J Neurosci. 2010;30:7761-9 pubmed publisher
Glasscock E, Yoo J, Chen T, Klassen T, Noebels J. Kv1.1 potassium channel deficiency reveals brain-driven cardiac dysfunction as a candidate mechanism for sudden unexplained death in epilepsy. J Neurosci. 2010;30:5167-75 pubmed publisher
Zoga V, Kawano T, Liang M, Bienengraeber M, Weihrauch D, McCallum B, et al. KATP channel subunits in rat dorsal root ganglia: alterations by painful axotomy. Mol Pain. 2010;6:6 pubmed publisher
Seidl A, Rubel E, Harris D. Mechanisms for adjusting interaural time differences to achieve binaural coincidence detection. J Neurosci. 2010;30:70-80 pubmed publisher
Prolo L, Vogel H, Reimer R. The lysosomal sialic acid transporter sialin is required for normal CNS myelination. J Neurosci. 2009;29:15355-65 pubmed publisher
Arnaud E, Zenker J, de Preux Charles A, Stendel C, Roos A, Medard J, et al. SH3TC2/KIAA1985 protein is required for proper myelination and the integrity of the node of Ranvier in the peripheral nervous system. Proc Natl Acad Sci U S A. 2009;106:17528-33 pubmed publisher
Crawford D, Mangiardi M, Xia X, López Valdés H, Tiwari Woodruff S. Functional recovery of callosal axons following demyelination: a critical window. Neuroscience. 2009;164:1407-21 pubmed publisher
Dours Zimmermann M, Maurer K, Rauch U, Stoffel W, Fassler R, Zimmermann D. Versican V2 assembles the extracellular matrix surrounding the nodes of ranvier in the CNS. J Neurosci. 2009;29:7731-42 pubmed publisher
Dupree J, Pomicter A. Myelin, DIGs, and membrane rafts in the central nervous system. Prostaglandins Other Lipid Mediat. 2010;91:118-29 pubmed publisher
Teigler A, Komljenovic D, Draguhn A, Gorgas K, Just W. Defects in myelination, paranode organization and Purkinje cell innervation in the ether lipid-deficient mouse cerebellum. Hum Mol Genet. 2009;18:1897-908 pubmed publisher
Sharkey L, Cheng X, Drews V, Buchner D, Jones J, Justice M, et al. The ataxia3 mutation in the N-terminal cytoplasmic domain of sodium channel Na(v)1.6 disrupts intracellular trafficking. J Neurosci. 2009;29:2733-41 pubmed publisher
Ogawa Y, Rasband M. Proteomic analysis of optic nerve lipid rafts reveals new paranodal proteins. J Neurosci Res. 2009;87:3502-10 pubmed publisher
O Malley H, Shreiner A, Chen G, Huffnagle G, Isom L. Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis. Mol Cell Neurosci. 2009;40:143-55 pubmed publisher
Jarjour A, Bull S, Almasieh M, Rajasekharan S, Baker K, Mui J, et al. Maintenance of axo-oligodendroglial paranodal junctions requires DCC and netrin-1. J Neurosci. 2008;28:11003-14 pubmed publisher
Martin P, Carnaud M, Garcia del Caño G, Irondelle M, Irinopoulou T, Girault J, et al. Schwannomin-interacting protein-1 isoform IQCJ-SCHIP-1 is a late component of nodes of Ranvier and axon initial segments. J Neurosci. 2008;28:6111-7 pubmed publisher
Windrem M, Schanz S, Guo M, Tian G, Washco V, Stanwood N, et al. Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse. Cell Stem Cell. 2008;2:553-65 pubmed publisher
Luo S, Perry G, Levinson S, Henry M. Nav1.7 expression is increased in painful human dental pulp. Mol Pain. 2008;4:16 pubmed publisher
Lasiene J, Shupe L, Perlmutter S, Horner P. No evidence for chronic demyelination in spared axons after spinal cord injury in a mouse. J Neurosci. 2008;28:3887-96 pubmed publisher
Rush A, Wittmack E, Tyrrell L, Black J, Dib Hajj S, Waxman S. Differential modulation of sodium channel Na(v)1.6 by two members of the fibroblast growth factor homologous factor 2 subfamily. Eur J Neurosci. 2006;23:2551-62 pubmed
product information
TargetType :
CAMs
Target :
CASPR/Neurexin IV
AccessionNum :
P97846
Clone :
K65/35
HumanGeneName :
CNTNAP1
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/K65_35.pdf
IsoType :
IgG1
ValidationT :
Pass
ValidationBrIB :
Pass
ValidationBrIHC :
Pass
ValidationKO :
Pass
Catalog :
73-001
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States