Recombinant human VHL protein | NKMAX VHL3001 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human VHL protein

catalog :

VHL3001

quantity :

20 ug

price :

55 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human VHL protein

Domain :

1-154aa

Catalog number (SKU) :

VHL3001

NCBI :

NP_000542.1

Description :

Von Hippel-Lindau disease (VHL) is a dominant inherited syndrome characterized by the predisposition to develop various kinds of benign and malignant tumors, including clear cell renal carcinomas, pheochromocytomas and hemangioblastomas of the central nervous system and retina. VHL syndrome is caused by germline mutation in the VHL tumor suppressor, and VHL tumors are associated with loss or mutation of the remaining wild-type allele. VHL has two domains: a roughly 100-residue NH2-terminal domain rich in beta sheet (beta-domain) and a smaller alpha-helical domain (alpha-domain), held together by two linkers and a polar interface. VHL protein is also involved in the degradation of hypoxia-inducible factor (HIF). VHL beta-domain (1-154aa) was overexpressed in E. coli and purified by using conventional chromatography techniques

Alternative Names :

Von Hippel-Lindau tumor suppressor isoform 1, Von Hippel-Lindau tumor suppressor isoform 1, HRCA1, RCA1, VHL1, Von Hippel-Lindau tumor suppressor isoform 1 pVHL, G7 protein, Elongin binding protein, HRCA 1, RCA 1, VHL, VHL 1, VHLH, Von Hippel Lindau disease tumor suppressor, von Hippel Lindau syndrome, von Hippel Lindau tumor suppressor,

Concentration :

1mg/ml (determined by Bradford assay)

Formulation :

Liquid in. phosphate-buffered Saline (pH 7.4) containing 1mM DTT, 2mM EDTA

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Latif F., et al. (1993) Science. 260(5112):1317-20;; Duan DR., et al. (1995) PNAS. 92(14):6459-63;; Maxwell PH., et al. (1999) Nature 399(6733):271-5;;

Purity :

> 85% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Cancer

Molecular Weight :

19.2 kDa (174aa) confirmed by MALDI-TOF

Amino Acid Sequence :

MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGP EESGPEELGA EEEMEAGRPR PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR DAGTHDGLLV NQTELFVPSL NVDGQPIFAN ITLP

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

P40337

Internal Search Terms :

VHL, Von Hippel-Lindau tumor suppressor isoform 1, Von Hippel-Lindau tumor suppressor isoform 1, HRCA1, RCA1, VHL1, Von Hippel-Lindau tumor suppressor isoform 1 pVHL, G7 protein, Elongin binding protein, HRCA 1, RCA 1, VHL, VHL 1, VHLH, Von Hippel Lindau disease tumor suppressor, von Hippel Lindau syndrome, von Hippel Lindau tumor suppressor,VHL3001-10ug,VHL3001-20ug,VHL3001-50ug,VHL3001-100ug,VHL3001-250ug,VHL3001-500ug,VHL3001-1mg,VHL3001-10,VHL3001-20,VHL3001-50,VHL3001-100,VHL3001-250,VHL3001-500,VHL3001-1

more info or order :

NKMAX product webpage