Recombinant human TPMT protein | NKMAX TPM0701 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human TPMT protein

catalog :

TPM0701

quantity :

20 ug

price :

105 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human TPMT protein

Domain :

1-245aa

Catalog number (SKU) :

TPM0701

NCBI :

AAH05339

Description :

TPMT, thiopurine S-methyltransferase, is a cytosolic enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine and azathioprine are used as chemotherapeutic agents. TPMT activity exhibits autosomal codominant genetic polymorphism, and patients inheriting TPMT-deficiency are at high risk of potentially fatal hematopoietic toxicity. Recombinant human TPMT was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

Thiopurine S-methyltransferase, Thiopurine S-methyltransferase, TPMT, Thiopurine S-methyltransferase HGNC:12014, S adenosyl L methionine thiopurine S methyltransferase, Thiopurine methyltransferase, Thiopurine S methyltransferase.

Concentration :

1mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.2mM PMSF, 2mM EDTA

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Tai HL., et al. (1997) Proc Natl Acad Sci uSA. 94:6444-9.;; Odani S., et al.(2001) J Biochem. 129(2):213-9.;;

Purity :

> 95% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Enzymes & Proteases

Molecular Weight :

28 kDa (245aa) confirmed by MALDI-TOF

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

MDGTRTSLDI EEYSDTEVQK NQVLTLEEWQ DKWVNGKTAF HQEQGHQLLK KHLDTFLKGK SGLRVFFPLC GKAVEMKWFA DRGHSVVGVE ISELGIQEFF TEQNLSYSEE PITEIPGTKV FKSSSGNISL YCCSIFDLPR TNIGKFDMIW DRGALVAINP GDRKCYADTM FSLLGKKFQY LLCVLSYDPT KHPGPPFYVP HAEIERLFGK ICNIRRLEKV DAFEERHKSW GIDCLFEKLY LLTEK

Tag :

Non-Tagged

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

Q9BS45

Internal Search Terms :

TPMT, Thiopurine S-methyltransferase, Thiopurine S-methyltransferase, TPMT, Thiopurine S-methyltransferase HGNC:12014, S adenosyl L methionine thiopurine S methyltransferase, Thiopurine methyltransferase, Thiopurine S methyltransferase.,TPM0701-10ug,TPM0701-20ug,TPM0701-50ug,TPM0701-100ug,TPM0701-250ug,TPM0701-500ug,TPM0701-1mg,TPM0701-10,TPM0701-20,TPM0701-50,TPM0701-100,TPM0701-250,TPM0701-500,TPM0701-1

more info or order :

NKMAX product webpage