protein

Recombinant human gamma-Synuclein protein

SNG2001

20 ug

55 USD

Recombinant human gamma-Synuclein protein

1-127aa

SNG2001

NP_003078.2

gamma-synuclein (Originally known as a breast cancer specific gene product, BCSG1) is an acidic neuronal protein of 127 amino acids. The protein coding region of gamma-synuclein was amplified by RT-PCR and cloned into an E. coli expression vector. gamma-synuclein was overexpressed in E. coli and purified to apparent homogeneity by taking advantage of the thermosolubility of the protein and by using conventional column chromatography techniques.

Synuclein gamma, SNCG, BCSG1, SR, Persyn, PRSN, Synoretin, Breast cancer-specific gene 1, ɣ-synuclein

1mg/ml (determined by BCA assay)

Liquid in. 20mM Tris-HCl buffer (pH 7.5) containing 0.1M NaCl

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Ji H., et al. (1997) Cancer Res. 57(4):759-64.

> 90% by SDS-PAGE

SDS-PAGE

Human

Neuroscience

13.3 kDa (127aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

< 1 EU per 1ug of protein (determined by LAL method)

MDVFKKGFSI AKEGVVGAVE KTKQGVTEAA EKTKEGVMYV GAKTKENVVQ SVTSVAEKTK EQANAVSEAV VSSVNTVATK TVEEAENIAV TSGVVRKEDL RPSAPQQEGV ASKEKEEVAE EAQSGGD

Non-Tagged

E.coli

Recombinant Protein

O76070

g-Synuclein, Synuclein gamma (breast cancer-specific protein 1), SNCG, BCSG1, PERSYN, PRSN, gamma-Synuclein, Persyn, Breast cancer-specific gene 1 protein, Synoretin, SR, gamma-synuclein, gamma synuclein, Synuclein, gamma (breast cancer-specific protein 1) BCSG 1, Breast cancer specific gene 1, Breast cancer specific gene 1 protein, Breast cancer specific protein 1, Gamma synuclein, SNCG protein, SR, Synuclein gamma,SNG2001-10ug,SNG2001-20ug,SNG2001-50ug,SNG2001-100ug,SNG2001-250ug,SNG2001-500ug,SNG2001-1mg,SNG2001-10,SNG2001-20,SNG2001-50,SNG2001-100,SNG2001-250,SNG2001-500,SNG2001-1

Ahn KJ, et al. Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein. (J Neurochem. 2006){https://pubmed.ncbi.nlm.nih.gov/16524375/};;Park JY, et al. Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinsons disease. (Glia. 2008){https://pubmed.ncbi.nlm.nih.gov/18449945/};;Kim KS, et al. Regulation of Weibel-Palade body exocytosis by alpha-synuclein in endothelial cells. (J Biol Chem. 2010){https://pubmed.ncbi.nlm.nih.gov/20448034/};;Kawakami F, et al. Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β. (FEBS J. 2011){https://pubmed.ncbi.nlm.nih.gov/21985244/};;Konno M, et al. Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy. (Mol Neurodegener. 2012){https://pubmed.ncbi.nlm.nih.gov/22892036/};;Førland MG, et al. Validation of a new assay for α-synuclein detection in cerebrospinal fluid. (Clin Chem Lab Med. 2017){https://pubmed.ncbi.nlm.nih.gov/27474841/}