protein

Recombinant human beta-Synuclein protein

SNB2001

20 ug

55 USD

Recombinant human beta-Synuclein protein

1-134aa

SNB2001

NP_001001502.1

beta-synuclein (amino acids 1-134), an acidic neuronal protein of 134 amino acids, is extremely heat-resistant. beta-synucelin also has a chaperone-like activity. Recently, beta-synuclein has been suggested to inhibit

Beta-synuclein, SNCB beta-Synuclein, B-synuclein, Phosphoneuroprotein 14, PNP14, Synuclein beta

1mg/ml (determined by BCA assay)

Liquid in. 20mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl,1mM MgCl2

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Jakes R., et al. (1994) FEBS lett. 345, 27-32.;; Kim J.,et al. (1997) Molecules and Cells. 7, 78-83.;; Hashimoto M., et al. (2001) Neuron 32, 213-223.;;

> 95% by SDS-PAGE

SDS-PAGE

Human

Neuroscience

14.2 kDa (134aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ EAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA

Non-Tagged

E.coli

Recombinant Protein

Q16143

b-Synuclein, Beta-synuclein, SNCB beta-Synuclein, B-synuclein, Beta synuclein, beta synuclein, Phosphoneuroprotein 14, PNP14, Synuclein beta,SNB2001-10ug,SNB2001-20ug,SNB2001-50ug,SNB2001-100ug,SNB2001-250ug,SNB2001-500ug,SNB2001-1mg,SNB2001-10,SNB2001-20,SNB2001-50,SNB2001-100,SNB2001-250,SNB2001-500,SNB2001-1

Ahn KJ, et al. Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein. (J Neurochem. 2006){https://pubmed.ncbi.nlm.nih.gov/16524375/};;JY Park, et al. Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinsons disease. (Glia. 2008){https://pubmed.ncbi.nlm.nih.gov/18449945/};;Kim KS, et al. Regulation of Weibel-Palade body exocytosis by alpha-synuclein in endothelial cells. (J Biol Chem. 2010){https://pubmed.ncbi.nlm.nih.gov/20448034/};;Kawakami F, et al. Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β. (FEBS J. 2011){https://pubmed.ncbi.nlm.nih.gov/21985244/};;Konno M, et al. Suppression of dynamin GTPase decreases a-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy. (Mol Neurodegener. 2012){https://pubmed.ncbi.nlm.nih.gov/22892036/};;Førland MG, et al. Validation of a new assay for α-synuclein detection in cerebrospinal fluid. (Clin Chem Lab Med. 2017){https://pubmed.ncbi.nlm.nih.gov/27474841/};;Kobayashi J, et al. Extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1-assisted dopamine transporter endocytosis. (FASEB J. 2019){https://pubmed.ncbi.nlm.nih.gov/31211923/}