protein

Recombinant human alpha-Synuclein E46K protein

SNA4001

20 ug

55 USD

Recombinant human alpha-Synuclein E46K protein

1-140aa

SNA4001

NP_000336.1

alpha-Synuclein E46K is a mutant form of alpha-synuclein which is changed at position 46 from glutamate (E) to lysine (K). Recent studies have shown that this mutant (E46K) of alpha-synuclein causes Parkinson and Lewy Body dementia (DLB). alpha-Synuclein E46K was overexpressed in E. coli and purified to apparent homogeneity by using conventional column chromatography techniques

SNCA, NACP, PARK1, PARK4, PD1, α-synuclein Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Parkinson disease 4, autosomal dominant Lewy body

1mg/ml (determined by BCA assay)

Liquid in. 20mM Tris-HCl buffer (pH 7.5) containing 0.1M NaCl

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Juan J.Zarranz, . (2004) Ann. Neurol. 55, 164-173.

> 95% by SDS-PAGE

SDS-PAGE

Human

Neuroscience

14.4 (140aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKKGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA

Non-Tagged

E.coli

Recombinant Protein

P37840

a-Synuclein E46K, SNCA, NACP, PARK1, alpha-Synuclein, alpha synuclein E46k, alpha-synuclein e46k, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Alpha synuclein, Alpha-synuclein isoform NACP140, alphaSYN, MGC105443, MGC110988, MGC127560, MGC64356, Non A beta component of AD amyloid, Non A4 component of amyloid precursor, Non-A-beta component of alzheimers disease amyloid, precursor of PARK 1, PARK 4, PARK4, Parkinson disease familial 1, PD 1, PD1, Synuclein alpha,SNA4001-10ug,SNA4001-20ug,SNA4001-50ug,SNA4001-100ug,SNA4001-250ug,SNA4001-500ug,SNA4001-1mg,SNA4001-10,SNA4001-20,SNA4001-50,SNA4001-100,SNA4001-250,SNA4001-500,SNA4001-1

Park JY, et al. Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinsons disease. (Glia. 2008){https://pubmed.ncbi.nlm.nih.gov/18449945/};;Kim KS, et al. Proteolytic cleavage of extracellular α-synuclein by plasmin: implications for Parkinson disease. (J Biol Chem. 2012){https://pubmed.ncbi.nlm.nih.gov/22619171/}