protein

Recombinant human alpha-Synuclein (61-140aa) protein

SNA2006

20 ug

55 USD

Recombinant human alpha-Synuclein (61-140aa) protein

61-140aa

SNA2006

NP_000336.1

A deletion mutant of alpha-synuclein (amino acids 61-140). Syn61-140 was overexpressed in E. coli and was purified to apparent homogeneity by taking advantage of the thermosolubility of protein and by using conventional column chromatography techniques. Additional amino acid (Met) is attached at the N-terminus.

SNCA, NACP, PARK1, PARK4, PD1, α-synuclein Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Parkinson disease 4, autosomal dominant Lewy body

1mg/ml (determined by BCA assay)

Liquid in. 20mM Tris-HCl buffer (pH 7.5) containing 0.1M NaCl

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Park SM., et al. (2002) Blood. 100(7):2506-14.;; Park SM., et al. (2002) Biochemistry. 41(12):4137-46.;;

> 95% by SDS-PAGE

SDS-PAGE

Human

Neuroscience

8.4 kDa (81aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

MEQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA

Non-Tagged

E.coli

Recombinant Protein

P37840

a-Synuclein (61140aa), SNCA, NACP, PARK1, alpha-Synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Alpha synuclein, Alpha-synuclein isoform NACP140, alphaSYN, MGC105443, MGC110988, MGC127560, MGC64356, Non A beta component of AD amyloid, Non A4 component of amyloid precursor, Non-A-beta component of alzheimers disease amyloid, precursor of PARK 1, PARK 4, PARK4, Parkinson disease familial 1, PD 1, PD1, Synuclein alpha,SNA2006-10ug,SNA2006-20ug,SNA2006-50ug,SNA2006-100ug,SNA2006-250ug,SNA2006-500ug,SNA2006-1mg,SNA2006-10,SNA2006-20,SNA2006-50,SNA2006-100,SNA2006-250,SNA2006-500,SNA2006-1

Kim EJ, et al. Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation. (J Biol Chem. 2006){https://pubmed.ncbi.nlm.nih.gov/16959772/};;Park JY, et al. Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinsons disease. (Glia. 2008){https://pubmed.ncbi.nlm.nih.gov/18449945/};;Fantini J, et al. The fusogenic tilted peptide (67-78) of α-synuclein is a cholesterol binding domain. (Biochim Biophys Acta. 2011){https://pubmed.ncbi.nlm.nih.gov/21756873/};;Kawakami F, et al. Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β. (FEBS J. 2011){https://pubmed.ncbi.nlm.nih.gov/21985244/}