Recombinant human PDH kinase 1/PDK1 protein | NKMAX PDK0904 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human PDH kinase 1/PDK1 protein

catalog :

PDK0904

quantity :

20 ug

price :

55 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human PDH kinase 1/PDK1 protein

Domain :

29-436aa

Catalog number (SKU) :

PDK0904

NCBI :

NP_002601

Description :

PDK1 (pyruvate dehydrogenase kinase isoform 1) is involved in the regulation of enzymatic activity of mammalian pyruvate dehydrogenase (PDH) that is a part of a mitochondrial multienzyme complex to catalyze the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. PDK1 has been found to serve as an effective therapeutic target for inhibition of glioblastoma growth. Recombinant human PDK1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

Pyruvate dehydrogenase kinase 1, Pyruvate dehydrogenase kinase, PDHK1, Isozyme 1, Isoenzyme

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 7.0) containing 100mM NaCl, 0.5mM DTT, 0.1mM EDTA, 0.1mM PMSF, 1mM MgCl2, 40% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Gudi R ., et al. (1995). J Biol chem. 270(48) : 28989-94;; Xie Z., et al. (2006). BMC Cancer. 6 :77;;

Purity :

> 95% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Enzymes & Proteases

Molecular Weight :

48.6 kDa (429aa)

Amino Acid Sequence :

MGSSHHHHHH SSGLVPRGSH MSSDSGSSPA SERGVPGQVD FYARFSPSPL SMKQFLDFGS VNACEKTSFM FLRQELPVRL ANIMKEISLL PDNLLRTPSV QLVQSWYIQS LQELLDFKDK SAEDAKAIYD FTDTVIRIRN RHNDVIPTMA QGVIEYKESF GVDPVTSQNV QYFLDRFYMS RISIRMLLNQ HSLLFGGKGK GSPSHRKHIG SINPNCNVLE VIKDGYENAR RLCDLYYINS PELELEELNA KSPGQPIQVV YVPSHLYHMV FELFKNAMRA TMEHHANRGV YPPIQVHVTL GNEDLTVKMS DRGGGVPLRK IDRLFNYMYS TAPRPRVETS RAVPLAGFGY GLPISRLYAQ YFQGDLKLYS LEGYGTDAVI YIKALSTDSI ERLPVYNKAA WKHYNTNHEA DDWCVPSREP KDMTTFRSA

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

Q15118

Internal Search Terms :

Pyruvate dehydrogenase kinase isozyme 1, Pyruvate dehydrogenase kinase isoform 1, Pyruvate dehydrogenase kinase 1, Pyruvate dehydrogenase kinase, PDK1, PDK 1, PDHK1, PDHK 1, Mitochondrial pyruvate dehydrogenase kinase isoenzyme1, Isozyme1, Isozyme 1 HGNC:8809, Isozyme 1, Isoenzyme1, Isoenzyme 1, PDK0904-10ug, PDK0904-20ug, PDK0904-50ug, PDK0904-100ug, PDK0904-250ug, PDK0904-500ug, PDK0904-1mg, PDK0904-010, PDK0904-020, PDK0904-050, PDK0904-100, PDK0904-250, PDK0904-500, PDK0904-01M

more info or order :

NKMAX product webpage