Recombinant human HTRA2/OMI (S306A) protein | NKMAX HTR0501 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human HTRA2/OMI (S306A) protein

catalog :

HTR0501

quantity :

20 ug

price :

55 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human HTRA2/OMI (S306A) protein

Domain :

134-458aa

Catalog number (SKU) :

HTR0501

NCBI :

NP_037379.1

Description :

HtrA2/Omi is a mammalian serine protease at high temperatures and has a chaperone activity at low temperature. The full-length HtrA2 is synthesized as a precursor protein and then targeted to the mitochondria where it is matured by the removal of N-terminal 133 residues. Mature HtrA2 consists of a putative transmembrane domain; an inhibitor of apoptosis protein (IAP) -binding motif; a single C-terminal PDZ domain that mediates protein-protein interactions. Recently, HtrA2 has known to contribute both to caspase-dependent and caspase-independent cell death. Mature form of HtrA2/Omi (residues 134-458) was overexpressed in E. coli, and purified by conventional column chromatography techniques.

Alternative Names :

HtrA serine peptidase 2, High temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI, PRSS25, OMI, PARK13

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Savopoulos JW., et al., (2000) Protein Expr. Purif. 19, 227-34;; Gray CW, et al., (2000) Eur. J. Biochem. 267, 5699-710 ;; Martins LM, et al., (2002) J. Biol. Chem. 277, 439-44;; Van Loo G, et al., (2002) Cell Death Differ. 9, 20-60;;

Purity :

> 95% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Enzymes & Proteases

Molecular Weight :

36 kDa (334aa) confirmed by MALDI-TOF

Amino Acid Sequence :

MAVPSPPPAS PRSQYNFIAD VVEKTAPAVV YIEILDRHPF LGREVPISNG SGFVVAADGL IVTNAHVVAD RRRVRVRLLS GDTYEAVVTA VDPVADIATL RIQTKEPLPT LPLGRSADVR QGEFVVAMGS PFALQNTITS GIVSSAQRPA RDLGLPQTNV EYIQTDAAID FGNAGGPLVN LDGEVIGVNT MKVTAGISFA IPSDRLREFL HRGEKKNSSS GISGSQRRYI GVMMLTLSPS ILAELQLREP SFPDVQHGVL IHKVILGSPA HRAGLRPGDV ILAIGEQMVQ NAEDVYEAVR TQSQLAVQIR RGRETLTLYV TPEVTE

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

O43464

Internal Search Terms :

HtrA2, Omi (S306A), High temperature requirement protein A2, HTRA2, OMI, PRSS25, HtrA2/Omi, EC 3.4.21.108, High temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, Serine proteinase OMI, Serine protease 25, Serine protease HTRA2, mitochondrial, High temperature requirement protein A2,HTR0501-10ug,HTR0501-20ug,HTR0501-50ug,HTR0501-100ug,HTR0501-250ug,HTR0501-500ug,HTR0501-1mg,HTR0501-10,HTR0501-20,HTR0501-50,HTR0501-100,HTR0501-250,HTR0501-500,HTR0501-1

more info or order :

NKMAX product webpage