Human TLR7 antibody | NKMAX ATR0601 product information

product summary

company name :

NKMAX

product type :

antibody

product name :

Human TLR7 antibody

catalog :

ATR0601

quantity :

50 ul

price :

170 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4F4

reactivity :

human

application :

ELISA, immunocytochemistry, FACS

more info or order :

NKMAX product webpage

product information

Product Type :

Antibodies

Item Name :

Human TLR7 antibody

Catalog number (SKU) :

ATR0601

NCBI :

NP_057646

Description :

TLR7 is one of toll-like receptors which are type I transmembrane proteins involved in innate immunity by recognizing microbial conserved structures. These proteins are characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain, and act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. Human TLR7 (hTLR7) is predominantly expressed in lung, placenta and spleen and hTLR7, 8 genes are located on the sex chromosome X. hTLR7 may play an important role in detecting and combating viral infections.

Alternative Names :

toll-like receptor 7, PRO285, UNQ248, tlr 7

Concentration :

1mg/ml (determined by BCA assay)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Lee J., et al. (2003) Proc. Natl. Acad. Sci. USA. 100, 6646-6651.;; Crozat K., et al. (2004) Proc. Natl. Acad. Sci. USA. 101, 6835-6836.;; Muzio M., et al. (1998) J. Exp. Med. 187, 2097-2101.;; Horng T., et al. (2002) Nature 420, 329-333.

Abs Host :

Mouse

Isotype :

IgG1 kappa

Immunogen :

Recombinant human TLR7 (451-500aa) purified from E. coli

Applications :

ELISA, ICC/IF, FACS

IF Comment And Pic :

ICC/IF analysis of TLR7 in THP-1 cells. The cell was stained with ATR0601 (1:100). The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue).

Reacts With :

Human

Clone Number :

4F4

Ab Usage :

The antibody has been tested by ELISA, ICC/IF and FACS analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

FACS Comment and Pic :

Flow cytometry analysis of TLR7 in THP-1 cells. The cell was stained with ATR0601 at 2-5ug for 1x10^6cells (red). A Goat anti mouse IgG (Alexa fluor 488) was used as the secondary antibody. Mouse monoclonal IgG was used as the isotype control (dark gray), cells without incubation with primary and secondary antibody was used as the negative control (light gray).

Antigen Species :

Human

Gene Category :

Immunology

Conjugation :

Unconjugated

Clonality Mono VS Poly :

Monoclonal

Ab Purification Comment :

By protein-G affinity chromatography

Product Type Name :

Monoclonal Antibody

UniProt No. :

Q9NYK1

Internal Search Terms :

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more info or order :

NKMAX product webpage