Recombinant human CD23/FCER2 protein | NKMAX ATGP4162 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human CD23/FCER2 protein

catalog :

ATGP4162

quantity :

10 ug

price :

130 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human CD23/FCER2 protein

Domain :

48-321aa

Catalog number (SKU) :

ATGP4162

NCBI :

NP_001993.2

Description :

CD23/FCER2, also known as low affinity immunoglobulin epsilon Fc receptor isoform a, is a member of subgroup II of the C-type (Ca++-dependent) lectin superfamily. It is a low affinity receptor for B cell specific antigen and IgE. Unlike many of the antibody receptors, CD23 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets. It plays an essential role in the growth and differentiation of B cells, and in the regulation of IgE production. This protein also exists in a soluble secretion form and functions as a powerful cleavage-promoting growth factor. Increased levels of soluble CD23/FCER2 lead to the recruitment of unaffected B cells in the presentation of antigen peptides to allergen-specific B cells. Recombinant human CD23/FCER2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Low affinity immunoglobulin epsilon Fc receptor, BLAST-2, C-type lectin domain family 4 member J, Fc-epsilon RII, Immunoglobulin E-binding factor, Lymphocyte IgE receptor, CD23, CD23A, CLEC4J, FCE2, IGEBF, FCER2

Concentration :

0.25mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Heyman, B., et al. (2000) Annu. Rev. Immunol. 18:709-737.;; Bajorath, J., et al. (1996) Protein Sci. 5:240-247.

Purity :

> 90% by SDS-PAGE

Bioactivity Comment Only :

Measured by its binding ability in a functional ELISA with Human IgE. The ED50 range ≤ 15 ug/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

32 kDa (283aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human IgE is coated at 5 ug/ml (100 ul/well) can bind Human CD23/FCER2. The ED50 range ≤ 15 ug/ml.

Amino Acid Sequence :

DTTQSLK QLEERAARNV SQVSKNLESH HGDQMAQKSQ STQISQELEE LRAEQQRLKS QDLELSWNLN GLQADLSSFK SQELNERNEA SDLLERLREE VTKLRMELQV SSGFVCNTCP EKWINFQRKC YYFGKGTKQW VHARYACDDM EGQLVSIHSP EEQDFLTKHA SHTGSWIGLR NLDLKGEFIW VDGSHVDYSN WAPGEPTSRS QGEDCVMMRG SGRWNDAFCD RKLGAWVCDR LATCTPPASE GSAESMGPDS RPDPDGRLPT PSAPLHS

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

P06734

Internal Search Terms :

ATGP4162-10ug, ATGP4162-20ug, ATGP4162-50ug, ATGP4162-100ug, ATGP4162-250ug, ATGP4162-500ug, ATGP4162-1mg, ATGP4162-010, ATGP4162-020, ATGP4162-050, ATGP4162-100, ATGP4162-250, ATGP4162-500, ATGP4162-01M, ATGP3705-10ug, ATGP3705-20ug, ATGP3705-50ug, ATGP3705-100ug, ATGP3705-250ug, ATGP3705-500ug, ATGP3705-1mg, ATGP3705-010, ATGP3705-020, ATGP3705-050, ATGP3705-100, ATGP3705-250, ATGP3705-500, ATGP3705-01M

more info or order :

NKMAX product webpage