Recombinant human LILRA3/CD85e protein | NKMAX ATGP4158 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human LILRA3/CD85e protein

catalog :

ATGP4158

quantity :

10 ug

price :

120 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human LILRA3/CD85e protein

Domain :

24-439aa

Catalog number (SKU) :

ATGP4158

NCBI :

NP_006856.3

Description :

LILRA3, also known as CD85 antigen-like family member E (CD85e), immunoglobulin-like transcript 6 (ILT-6), and leukocyte immunoglobulin-like receptor 4 (LIR-4), acts as a soluble receptor for class I MHC antigens. It binds both classical and non-classical HLA class I molecules, albeit with reduced affinities compared to LILRB1 or LILRB2. Additionally, LILRA3 exhibits high affinity for monocyte surfaces, effectively suppressing LPS-induced TNF-alpha production. Unlike many of its family, LILRA3 lacks a transmembrane domain. The function of LILRA3 is currently unknown. However, it is highly homologous to other LILR genes and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the LILRA3 might impair interactions of membrane-bound LILRs with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease. Recombinant human LILRA3/CD85e, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

Leukocyte immunoglobulin-like receptor subfamily A member 3, leukocyte immunoglobulin-like receptor subfamily A member 3 isoform 1, CD85 antigen-like family member E, Immunoglobulin-like transcript 6, Leukocyte immunoglobulin-like receptor 4, Monocyte inhibitory receptor HM43/HM31, ILT-6, LIR-4, ILT6, LIR4, LILRA3, CD85e

Concentration :

0.5mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Jones DC., et al, (2011) Journal of Immunology. 186:2990-2997.;; Borges L., et al,(1997) Journal of Immunology. 159:5192-5196.

Purity :

> 95% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

72.2kDa (658aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

GPLPKPT LWAEPGSVIT QGSPVTLRCQ GSLETQEYHL YREKKTALWI TRIPQELVKK GQFPILSITW EHAGRYCCIY GSHTAGLSES SDPLELVVTG AYSKPTLSAL PSPVVTSGGN VTIQCDSQVA FDGFILCKEG EDEHPQCLNS HSHARGSSRA IFSVGPVSPS RRWSYRCYGY DSRAPYVWSL PSDLLGLLVP GVSKKPSLSV QPGPVVAPGE KLTFQCGSDA GYDRFVLYKE WGRDFLQRPG RQPQAGLSQA NFTLGPVSRS YGGQYTCSGA YNLSSEWSAP SDPLDILITG QIRARPFLSV RPGPTVASGE NVTLLCQSQG GMHTFLLTKE GAADSPLRLK SKRQSHKYQA EFPMSPVTSA HAGTYRCYGS LSSNPYLLTH PSDPLELVVS GAAETLSPPQ NKSDSKAGE

Tag :

hIgG-His-Tag

Expression System :

HEK293

Predicted nterm :

Asp

Product Type Name :

Recombinant Protein

UniProt No. :

Q8N6C8

Internal Search Terms :

ATGP4158-10ug, ATGP4158-20ug, ATGP4158-50ug, ATGP4158-100ug, ATGP4158-250ug, ATGP4158-500ug, ATGP4158-1mg, ATGP4158-010, ATGP4158-020, ATGP4158-050, ATGP4158-100, ATGP4158-250, ATGP4158-500, ATGP4158-01M

more info or order :

NKMAX product webpage