Recombinant human TrkB protein | NKMAX ATGP4152 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human TrkB protein

catalog :

ATGP4152

quantity :

10 ug

price :

110 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human TrkB protein

Domain :

32-430aa

Catalog number (SKU) :

ATGP4152

NCBI :

NP_001018074.1

Description :

TrkB/NTRK2, also known as BDNF/NT-3 growth factors receptor, is a receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Trk family are four members ; TrkA, TrkB, TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities and TrkB has the highest affinity for BDNF. It plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. Mutations in TrkB have been associated with obesity and mood disorders. Recombinant human TrkB/NTRK2, fused to hIgG-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

GP145-TrkB, trk-B, TRKB, NTRK2, OBHD, BDNF/NT-3 growth factors receptor isoform c, BDNF/NT-3 growth factors receptor, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin-related kinase B

Concentration :

1mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Yeo GS., et al. (2004) Nat Neurosci. 7:1187-1189.;; Banfield MJ., et al. (2001) Structure. 9:1191-1199.

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Neuroscience

Molecular Weight :

70.3kDa (632aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

CPTSCKCSAS RIWCSDPSPG IVAFPRLEPN SVDPENITEI FIANQKRLEI INEDDVEAYV GLRNLTIVDS GLKFVAHKAF LKNSNLQHIN FTRNKLTSLS RKHFRHLDLS ELILVGNPFT CSCDIMWIKT LQEAKSSPDT QDLYCLNESS KNIPLANLQI PNCGLPSANL AAPNLTVEEG KSITLSCSVA GDPVPNMYWD VGNLVSKHMN ETSHTQGSLR ITNISSDDSG KQISCVAENL VGEDQDSVNL TVHFAPTITF LESPTSDHHW CIPFTVKGNP KPALQWFYNG AILNESKYIC TKIHVTNHTE YHGCLQLDNP THMNNGDYTL IAKNEYGKDE KQISAHFMGW PGIDDGANPN YPDVIYEDYG TAANDIGDTT NRSNEIPSTD VTDKTGREH

Tag :

hIgG-Tag

Expression System :

HEK293

Predicted nterm :

Cys31

Product Type Name :

Recombinant Protein

UniProt No. :

Q16620

Internal Search Terms :

ATGP4152-10ug, ATGP4152-20ug, ATGP4152-50ug, ATGP4152-100ug, ATGP4152-250ug, ATGP4152-500ug, ATGP4152-1mg, ATGP4152, ATGP4152-020, ATGP4152-050, ATGP4152-100, ATGP4152-250, ATGP4152-500, ATGP4152-01M,ATGP3264-10ug, ATGP3264-20ug, ATGP3264-50ug, ATGP3264-100ug, ATGP3264-250ug, ATGP3264-500ug, ATGP3264-1mg, ATGP3264, ATGP3264-020, ATGP3264-050, ATGP3264-100, ATGP3264-250, ATGP3264-500, ATGP3264-01M

more info or order :

NKMAX product webpage