Recombinant human Fc gamma RIIB/CD32b protein | NKMAX ATGP4149 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human Fc gamma RIIB/CD32b protein

catalog :

ATGP4149

quantity :

10 ug

price :

130 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human Fc gamma RIIB/CD32b protein

Domain :

46-217aa

Catalog number (SKU) :

ATGP4149

NCBI :

NP_001002274.1

Description :

Fc gamma RIIB/CD32b, also known as FCGR2B, belongs to the Ig superfamily. It is a low-affinity receptor for the Fc region of immunoglobulins gamma that are complexed or aggregated. It participates in various effector and regulatory functions, such as phagocytosis of immune complexes and modulation of antibody production by B cells. Fc gamma RIIB/CD32b is expressed on B cells, monocytes, dendritic cells, neutrophils, mast cells, and basophils. When Fc gamma RIIB is ligated, it inhibits B cell expansion, plasma cell differentiation, production of autoimmune rheumatoid factors, and down-regulates TLR4 with reduced LPS responsiveness. Recombinant human Fc gamma RIIB/CD32b, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

Low affinity immunoglobulin gamma Fc region receptor II-b isoform3, IgG Fc receptor II-b, CDw32, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b, CD32, FCGR2B, FCG2, IGFR2, Fc fragment of IgG, low affinity II, low affinity IIb, Low affinity immunoglobulin gamma Fc region receptor II-c, IgG Fc receptor II-c, Fc-gamma RII-c, Fc fragment of IgG receptor IIb, Fc-gamma-RIIc, Fc gamma RIIb, CD32B, FcgammaRIIb, FCGR2, FCGR2C, FcGRIIB, FcRII-c

Concentration :

1mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Van de Winkel, J. and P. Capes (1993) Immunol. Today 14:215-221.;; Raghaven, M. and P. Bjorkman (1996) Annu. Rev. Cell Dev. Biol. 12:181-220.;; Ravetch, J. and S. Bolland (2001) Annu. Rev. Immunol. 19:275-290.

Purity :

> 95% by SDS-PAGE

Bioactivity Comment Only :

Measured by its binding ability in a functional ELISA with Human IgG1 Fc (CAT# ATGP4094).

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Immunology

Additional Comment Only :

ATGP1822 has replaced with a catalog number ATGP4149.

Molecular Weight :

20.1kDa (178aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human Fc gamma RIIB/CD32b (CAT# ATGP4149) is coated at 10 ug/ml (100 ul/well) can bind Human IgG1 Fc (CAT# ATGP4094) in a Functional ELISA assay.

Amino Acid Sequence :

APPKAVLKLE PQWINVLQED SVTLTCRGTH SPESDSIQWF HNGNLIPTHT QPSYRFKANN NDSGEYTCQT GQTSLSDPVH LTVLSEWLVL QTPHLEFQEG ETIVLRCHSW KDKPLVKVTF FQNGKSKKFS RSDPNFSIPQ ANHSHSGDYH CTGNIGYTLY SSKPVTITVQ AP

Tag :

His-Tag

Expression System :

HEK293

Predicted nterm :

Ala 46

Product Type Name :

Recombinant Protein

UniProt No. :

P31994

Internal Search Terms :

ATGP4149-10ug, ATGP4149-20ug, ATGP4149-50ug, ATGP4149-100ug, ATGP4149-250ug, ATGP4149-500ug, ATGP4149-1mg, ATGP4149-010, ATGP4149-020, ATGP4149-050, ATGP4149-100, ATGP4149-250, ATGP4149-500, ATGP4149-01M, ATGP1822-10ug, ATGP1822-20ug, ATGP1822-50ug, ATGP1822-100ug, ATGP1822-250ug, ATGP1822-500ug, ATGP1822-1mg, ATGP1822-010, ATGP1822-020, ATGP1822-050, ATGP1822-100, ATGP1822-250, ATGP1822-500, ATGP1822-01M

more info or order :

NKMAX product webpage