Recombinant human semaphorin-4D protein | NKMAX ATGP4145 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human semaphorin-4D protein

catalog :

ATGP4145

quantity :

10 ug

price :

120 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human semaphorin-4D protein

Domain :

22-734aa

Catalog number (SKU) :

ATGP4145

NCBI :

NP_006369

Description :

Semaphorin4D, also known as CD100, is a member of the Class 4 family of transmembrane immune and nervous system semaphorins. It is an important mediator of the movement and differentiation of multiple cell types, including those of the immune, vascular, and nervous systems. It serves important roles in T cell priming, antibody production, and cell-to-cell adhesion. Sema4D, produced by T cells, activated B cells and dendritic cells acts through a low affinity receptor termed CD72 in the immune system. Unligated CD72 inhibits antigen presenting cells that express it, and this inhibition is relieved by Sema4D binding. It is reflected in its ability to inhibit ovarian carcinoma cell survival.Recombinant human semaphorin-4D, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

SEMA4D, SEMA-4D, semaphorin-4D isoform 1, semaphorin4D, C9orf164, CD100, coll-4, COLL4, M-sema-G, SEMAJ, previously Sem J, G or C-like 2, A8, BB18, GR3

Concentration :

1mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Kumanogoh, A. and H. Kikutani (2004) Cell. Mol. Life Sci. 61:292-300.;; Janssen, B.J.C. et al. (2010) Nature 467:1118-1122.;; Kumanogoh, A. et al. (2005) Int. Immunol. 17:1277-1282.;; Ishida, I. et al. (2003) Int. Immunol. 15:1027-1034.;;

Purity :

> 95% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Immunology, Adhesion & Movement

Molecular Weight :

106.1kDa (952aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

MAFAPIPRIT WEHREVHLVQ FHEPDIYNYS ALLLSEDKDT LYIGAREAVF AVNALNISEK QHEVYWKVSE DKKAKCAEKG KSKQTECLNY IRVLQPLSAT SLYVCGTNAF QPACDHLNLT SFKFLGKNED GKGRCPFDPA HSYTSVMVDG ELYSGTSYNF LGSEPIISRN SSHSPLRTEY AIPWLNEPSF VFADVIRKSP DSPDGEDDRV YFFFTEVSVE YEFVFRVLIP RIARVCKGDQ GGLRTLQKKW TSFLKARLIC SRPDSGLVFN VLRDVFVLRS PGLKVPVFYA LFTPQLNNVG LSAVCAYNLS TAEEVFSHGK YMQSTTVEQS HTKWVRYNGP VPKPRPGACI DSEARAANYT SSLNLPDKTL QFVKDHPLMD DSVTPIDNRP RLIKKDVNYT QIVVDRTQAL DGTVYDVMFV STDRGALHKA ISLEHAVHII EETQLFQDFE PVQTLLLSSK KGNRFVYAGS NSGVVQAPLA FCGKHGTCED CVLARDPYCA WSPPTATCVA LHQTESPSRG LIQEMSGDAS VCPDKSKGSY RQHFFKHGGT AELKCSQKSN LARVFWKFQN GVLKAESPKY GLMGRKNLLI FNLSEGDSGV YQCLSEERVK NKTVFQVVAK HVLEVKVVPK PVVAPTLSVV QTEGSRIATK VLVASTQGSS PPTPAVQATS SGAITLPPKP APTGTSCEPK IVINTVPQLH SEKTMYLKSS DNR

Tag :

hIgG-His-Tag

Expression System :

HEK293

Predicted nterm :

Met22

Product Type Name :

Recombinant Protein

UniProt No. :

Q92854

Internal Search Terms :

ATGP4145-10ug, ATGP4145-20ug, ATGP4145-50ug, ATGP4145-100ug, ATGP4145-250ug, ATGP4145-500ug, ATGP4145-1mg, ATGP4145-010, ATGP4145-020, ATGP4145-050, ATGP4145-100, ATGP4145-250, ATGP4145-500, ATGP4145-01M

more info or order :

NKMAX product webpage