Recombinant mouse IGFBP-2 protein | NKMAX ATGP4144 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant mouse IGFBP-2 protein

catalog :

ATGP4144

quantity :

10 ug

price :

160 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant mouse IGFBP-2 protein

Domain :

35-305aa

Catalog number (SKU) :

ATGP4144

NCBI :

NP_032368.2

Description :

IGFBP-2, also known as insulin-like growth factor binding protein 2, is a member of IGFBP superfamily. IGFBPs modulate the biological activities of IGF proteins and have a high affinity for IGFs. IGFBPs are not merely carrier proteins for IGFs, but hold a central position in IGF ligand-receptor interactions through influences on both the bioavailability and distribution of IGFs in the extracellular environment. During development, IGFBP-2 is expressed in a number of tissues. The highest expression level is found in the central nervous system. In adults, high expression levels are also detected in the central nervous system and in a number of reproductive tissues.This protein binds preferentially to IGF-2, exhibiting a 2 - 10 fold higher affinity for IGF-2 than for IGF-1. Also, it is overexpressed in many malignancies and is often correlated with an increasingly malignant status of the tumor, pointing to the potential involvement of IGFBP-2 in tumorigenesis. Recombinant mouse IGFBP-2, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

insulin-like growth factor binding protein 2 isoform 1,insulin-like growth factor binding protein 2, IBP-2, Igfbp-2, mIGFBP-2, IGF-binding protein 2, Igfbp2

Concentration :

1mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Yoshiyuki H., et al, (1994) Cellular Physiology. 158:444-450. ;; Agarwal N., et al, (1991) Exp Eye Res. 52:549-561.

Purity :

> 85% by SDS-PAGE

Bioactivity Comment Only :

Measured by its ability to inhibit proliferation using MCF-7 human breast cancer cells in the presence of Mouse IGF-2. The ED50 range ≤ 0.7 ug/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Mouse

Gene Category :

Signal Transduction, Hormones & Cytokines

Molecular Weight :

30.3kDa (277aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Mouse IGFBP-2 inhibit proliferation using MCF-7 human breast cancer cells in the presence of Mouse IGF-2. The ED50 range ≤ 0.7 ug/ml.

Amino Acid Sequence :

EVLFRCPPCT PERLAACGPP PDAPCAELVR EPGCGCCSVC ARQEGEACGV YIPRCAQTLR CYPNPGSELP LKALVTGAGT CEKRRVGTTP QQVADSDDDH SEGGLVENHV DGTMNMLGGG SSAGRKPLKS GMKELAVFRE KVNEQHRQMG KGAKHLSLEE PKKLRPPPAR TPCQQELDQV LERISTMRLP DDRGPLEHLY SLHIPNCDKH GRYNLKQCKM SLNGQRGECW CVNPNTGKPI QGAPTIRGDP ECHLFYNEQQ ETGGAHAQSV Q

Tag :

His-Tag

Expression System :

HEK293

Predicted nterm :

Glu35

Product Type Name :

Recombinant Protein

UniProt No. :

P47877

Internal Search Terms :

ATGP4144-10ug, ATGP4144-20ug, ATGP4144-50ug, ATGP4144-100ug, ATGP4144-250ug, ATGP4144-500ug, ATGP4144-1mg, ATGP4144, ATGP4144-020, ATGP4144-050, ATGP4144-100, ATGP4144-250, ATGP4144-500, ATGP4144-01M

more info or order :

NKMAX product webpage