Recombinant human PlGF-1/PGF protein | NKMAX ATGP4140 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human PlGF-1/PGF protein

catalog :

ATGP4140

quantity :

10 ug

price :

116 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human PlGF-1/PGF protein

Domain :

19-149 aa

Catalog number (SKU) :

ATGP4140

NCBI :

NP_001193941.1

Description :

Placenta growth factor (PlGF/PGF) is a member of the PDGF/VEGF-sub-family - a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. There are three isoforms of this protein: PlGF-1, PlGF-2, PlGF-3. PlGF-2 is only found in early placenta up until the 8th week of development, while PlGF-1 is specifically found in the colon as well as mammary carcinomas. PlGF induces monocyte activation, migration, and production of inflammatory cytokines and VEGF. Also, PlGF is ultimately associated with angiogenesis. These activities facilitate wound, bone fracture, and cardiac repair, but also contribute to inflammation in active sickle cell disease and atherosclerosis. Recombinant human PlGF-1/PGF, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

Placenta growth factor, PlGF, PGF, PGFL, PLGF, placenta growth factor isoform 2

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Hauser, S. and H.A. Weich (1993) Growth Factors. 9:259-268.;; Maglione, D., et al, (1993) Oncogene. 8:925-931.;; Roncal, C., et al, (2010) Cardiovasc. Res. 86:29-36.

Purity :

> 90% by SDS-PAGE

Bioactivity Comment Only :

Measured by its binding ability in a functional ELISA with Human VEGFR1/Flt-1 (CAT# ATGP4101).

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Angiogenesis, Cardiovascular

Molecular Weight :

15.5kDa (137aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human PGF/PLGF-1 is coated at 2 ug/ml (100 ul/well) can bind Human VEGFR1/Flt-1 (CAT# ATGP4101) in a Functional ELISA assay.

Amino Acid Sequence :

LPAVPPQQWA LSAGNGSSEV EVVPFQEVWG RSYCRALERL VDVVSEYPSE VEHMFSPSCV SLLRCTGCCG DENLHCVPVE TANVTMQLLK IRSGDRPSYV ELTFSQHVRC ECRPLREKMK PERCGDAVPR R

Tag :

His-Tag

Expression System :

HEK293

Predicted nterm :

Leu 19

Product Type Name :

Recombinant Protein

UniProt No. :

P49763-2

Internal Search Terms :

ATGP4140-10ug, ATGP4140-20ug, ATGP4140-50ug, ATGP4140-100ug, ATGP4140-250ug, ATGP4140-500ug, ATGP4140-1mg, ATGP4140-010, ATGP4140-020, ATGP4140-050, ATGP4140-100, ATGP4140-250, ATGP4140-500, ATGP4140-01M

more info or order :

NKMAX product webpage