Recombinant human OX40 Ligand/TNFSF4 protein | NKMAX ATGP4136 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human OX40 Ligand/TNFSF4 protein

catalog :

ATGP4136

quantity :

10 ug

price :

160 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human OX40 Ligand/TNFSF4 protein

Domain :

51-183aa

Catalog number (SKU) :

ATGP4136

NCBI :

NP_003317.1

Description :

OX40 Ligand/TNFSF4, also known as Inositol monophosphatase 3, is a member of the tumor necrosis factor (TNF) receptor family. It is expressed on many antigen-presenting cells such as DC2s, macrophages, and activated B lymphocytes. The receptor for OX40L is OX40 that is expressed predominantly on activated CD4+ T cells. Expression of OX40 is transient following engagement of T cell receptors. The ligation of OX40-OX40L is a source of survival signal for T cells and enables the development of memory T cells. Also, It stimulates proliferation and differentiation of activated B cells, and increases immunoglobulin secretion. OX40-OX40 Ligand signaling is involved in graft-versus-host disease and autoimmune disease . Mutations in OX40 and OX40 Ligand are associated with cardiovascular disease. Recombinant human OX40 Ligand/TNFSF4, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

Tumor necrosis factor superfamily member 4 isoform 1, Glycoprotein Gp34, TAX transcriptionally-activated glycoprotein 1, Ath1, Ath-1, CD134L, OX40 ligand, OX40L, 34kD taxtranscriptionally activated glycoprotein 1, gp34, TXGP1, Txgp1l, TNLG2B, CD252, TNFSF4

Concentration :

1mg/ml (determined by Bradford assay)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Damayanti T., et al, (2010) Am. J. Respir. Crit. Care Med. 181:688-698.;; Ishii N., et al, (2010) Adv. Immunol. 105:63-98.

Purity :

> 90% by SDS-PAGE

Bioactivity Comment Only :

Measured by its binding ability in a functional ELISA with Human OX40/TNFRSF4 (CAT# ATGP4045).

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

16.2kDa (139aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human OX40 Ligand/TNFSF4 is coated at 1 ug/ml (100 ul/well) can bind Human OX40/TNFRSF4 (CAT# ATGP4045) in a Functional ELISA assay.

Amino Acid Sequence :

QVSHRYPRIQ SIKVQFTEYK KEKGFILTSQ KEDEIMKVQN NSVIINCDGF YLISLKGYFS QEVNISLHYQ KDEEPLFQLK KVRSVNSLMV ASLTYKDKVY LNVTTDNTSL DDFHVNGGEL ILIHQNPGEF CVL

Tag :

His-Tag

Expression System :

HEK293

Predicted nterm :

Gln51

Product Type Name :

Recombinant Protein

UniProt No. :

P23510

Internal Search Terms :

ATGP4136-10ug, ATGP4136-20ug, ATGP4136-50ug, ATGP4136-100ug, ATGP4136-250ug, ATGP4136-500ug, ATGP4136-1mg, ATGP4136-010, ATGP4136-020, ATGP4136-050, ATGP4136-100, ATGP4136-250, ATGP4136-500, ATGP4136-01M

more info or order :

NKMAX product webpage