Recombinant human TGF-beta RI/ALK-5 protein | NKMAX ATGP4134 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human TGF-beta RI/ALK-5 protein

catalog :

ATGP4134

quantity :

10 ug

price :

140 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human TGF-beta RI/ALK-5 protein

Domain :

27-126aa

Catalog number (SKU) :

ATGP4134

NCBI :

NP_004603.1

Description :

TGFBR1, also known as TGF-beta receptor type-1 isoform 1, is a single-pass type 1 membrane protein which belongs to the protein kinase superfamily and TGFB receptor subfamily. This protein is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. Also, it plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages. Defects in TGFBR1 are the cause of Loeys-Dietz syndrome type 1A (LDS1A), Loeys-Diets syndrome type 2A (LDS2A), and aortic aneurysm familial thoracic type 5 (AAT5). Recombinant human TGFBR1, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

TGF-beta receptor type-1 isoform 1, TGFBR1, AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, tbetaR-I, TBR-I, TBRI, TGFR-1, Activin A receptor type II-like protein kinase of 53kD, Activin receptor-like kinase 5, Serine/threonine-protein kinase receptor R4, TGF-beta type I receptor, Transforming growth factor-beta receptor type I

Concentration :

0.5mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Wrana JL., et al, (1992) Cell 71:1003-1014.;; Huse M., et al, (1999) Cell 96:425-436.

Purity :

> 90% by SDS-PAGE

Bioactivity Comment Only :

Measured by its binding ability in a functional ELISA with Mouse CD105 (CAT# ATGP3361). The ED50 range ≤ 2 ug/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Signal Transduction, Angiogenesis, Cardiovascular

Molecular Weight :

38kDa (342aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Mouse CD105 (CAT# ATGP3361) is coated at 10 ug/ml (100 ul/well) can bind Human TGF-beta RI/ALK-5. The ED50 range ≤ 2 ug/ml.

Amino Acid Sequence :

LLPGATA LQCFCHLCTK DNFTCVTDGL CFVSVTETTD KVIHNSMCIA EIDLIPRDRP FVCAPSSKTG SVTTTYCCNQ DHCNKIELPT TVKSSPGLGP VEL

Tag :

hIgG-His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

P36897

Internal Search Terms :

ATGP4134-10ug, ATGP4134-20ug, ATGP4134-50ug, ATGP4134-100ug, ATGP4134-250ug, ATGP4134-500ug, ATGP4134-1mg, ATGP4134-010, ATGP4134-020, ATGP4134-050, ATGP4134-100, ATGP4134-250, ATGP4134-500, ATGP4134-01M, ATGP3735-10ug, ATGP3735-20ug, ATGP3735-50ug, ATGP3735-100ug, ATGP3735-250ug, ATGP3735-500ug, ATGP3735-1mg, ATGP3735, ATGP3735-020, ATGP3735-050, ATGP3735-100, ATGP3735-250, ATGP3735-500, ATGP3735-01M

more info or order :

NKMAX product webpage