protein

Recombinant human BAFF R/TNFRSF13C protein

ATGP4131

10 ug

130 USD

Recombinant human BAFF R/TNFRSF13C protein

1-78aa

ATGP4131

NP_443177.1

BAFFR, also known as TNFRSF13C, is a member of the tumor necrosis factor receptor superfamily. Members of the TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity and in cellular apoptosis process. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL, BAFFR selectively binds BAFF. The BAFFR extracellular domain lacks the CRD (TNF receptor canonical cysteine-rich domain and contains only a partial CRD with four cysteine residues. It is highly expressed in spleen, lymph node and resting B cells and is thought the principal receptor required for BAFF-mediated mature B-cell survival. It has been proposed that abnormally high levels of BAFFR may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. Recombinant human BAFFR, fused to hIgG-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Tumor necrosis factor receptor superfamily member 13C, B-cell-activating factor receptor, BAFF receptor, BAFF-R, BLyS receptor 3, BROMIX, CD268, CVID4, prolixin, TNFRSF13C, Br3

1mg/ml (determined by Absorbance at 280nm)

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Losi CG, et al. (2005) J Clin Immunol. 25:496-502.;; Rolink, A.G, et al. (2002) Curr. Opin. Immunol. 14:266-275.

> 95% by SDS-PAGE

Measured by its binding ability in a functional ELISA with Human BAFF (CAT# ATGP4139). The ED50 range ≤ 0.7 ug/ml.

SDS-PAGE, Bioactivity

Human

Signal Transduction, Growth factors

34.4kDa (314aa)

< 1 EU per 1ug of protein (determined by LAL method)

Human BAFF (CAT# ATGP4139) is coated at 5 ug/ml (100 ul/well) can bind Human BAFFR. The ED50 range ≤ 0.7 ug/ml.

MRRGPRS LRGRDAPAPT PCVPAECFDL LVRHCVACGL LRTPRPKPAG ASSPAPRTAL QPQESVGAGA GEAALPLPGL L

hIgG-Tag

HEK293

Asp

Recombinant Protein

Q96RJ3

ATGP4131-10ug, ATGP4131-20ug, ATGP4131-50ug, ATGP4131-100ug, ATGP4131-250ug, ATGP4131-500ug, ATGP4131-1mg, ATGP4131-010, ATGP4131-020, ATGP4131-050, ATGP4131-100, ATGP4131-250, ATGP4131-500, ATGP4131-01M