product summary
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company name :
NKMAX
product type :
protein
product name :
Recombinant human IBSP/Sialoprotein II protein
catalog :
ATGP4129
quantity :
10 ug
price :
130 USD
more info or order :
product information
Product Type :
Proteins
Item Name :
Recombinant human IBSP/Sialoprotein II protein
Domain :
17-317aa
Catalog number (SKU) :
ATGP4129
NCBI :
NP_004958.2
Description :
IBSP, also known as Sialoprotein II, is a monomeric noncollagenous member of the SIBLING family of extracellular matrix (ECM) proteins. It is synthesized by platelets, osteoblasts, osteocytes, odontoblasts, osteoclasts and bone marrow stromal cells. It is a key mediator of the hypertrophic chondrocytes-induced angiogenesis. It was associated with the severity of histological cartilage lesions and with vascular density at the osteochondral junction. Recombinant human IBSP/Sialoprotein II, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Alternative Names :
Bone sialoprotein II, bone sialoprotein 2, BSP II, BSP, BSP-II, SP-II, Cell-binding sialoprotein, Integrin-binding sialoprotein, IBSP, BNSP
Concentration :
0.5mg/ml (determined by Absorbance at 280nm)
Formulation :
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Storage :
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
General References :
Pesesse L., et al. (2014) Osteoarthritis Cartilage. 22:547-556.;; Kruger TE., et al. (2014) Crit Rev Oncol Hematol. 89:330-341.
Purity :
> 90% by SDS-PAGE
Bioactivity Comment Only :
Measured by the ability of the immobilized protein to support the adhesion of MCF7 human breast cancer cells. When cells are added to Human IBSP coated plates 3 ug/ml. This effect is more to 40%.
Applications :
SDS-PAGE, Bioactivity
Antigen Species :
Human
Gene Category :
Signal Transduction, Cytoskeleton
Molecular Weight :
34.3kDa (307aa)
Endotoxin :
< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment and Pics :
Human IBSP stimulates cell adhesion of the MCF7 human breast cancer cells. This effect is more to 40%.
Amino Acid Sequence :
FSMKNLHRRV KIEDSEENGV FKYRPRYYLY KHAYFYPHLK RFPVQGSSDS SEENGDDSSE EEEEEEETSN EGENNEESNE DEDSEAENTT LSATTLGYGE DATPGTGYTG LAAIQLPKKA GDITNKATKE KESDEEEEEE EEGNENEESE AEVDENEQGI NGTSTNSTEA ENGNGSSGGD NGEEGEEESV TGANAEDTTE TGRQGKGTSK TTTSPNGGFE PTTPPQVYRT TSPPFGKTTT VEYEGEYEYT GANEYDNGYE IYESENGEPR GDNYRAYEDE YSYFKGQGYD GYDGQNYYHH Q
Tag :
His-Tag
Expression System :
HEK293
Predicted nterm :
Phe 17
Product Type Name :
Recombinant Protein
UniProt No. :
P21815
Internal Search Terms :
ATGP4129-10ug, ATGP4129-20ug, ATGP4129-50ug, ATGP4129-100ug, ATGP4129-250ug, ATGP4129-500ug, ATGP4129-1mg, ATGP4129-010, ATGP4129-020, ATGP4129-050, ATGP4129-100, ATGP4129-250, ATGP4129-500, ATGP4129-01M, ATGP3388-10ug, ATGP3388-20ug, ATGP3388-50ug, ATGP3388-100ug, ATGP3388-250ug, ATGP3388-500ug, ATGP3388-1mg, ATGP3388-010, ATGP3388-020, ATGP3388-050, ATGP3388-100, ATGP3388-250, ATGP3388-500, ATGP3388-01M
more info or order :
company information
NKMAX
SNUH Health Care Innovation Park 6F
172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
https://www.nkmaxbio.com172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
82-31-8017-8114
headquarters: South Korea
NKMAX Co. Ltd. is a biotech company that manufactures and supplies a unique line of quality proteins and antibodies worldwide to both researchers and retailers.