Recombinant mouse IL-17A protein | NKMAX ATGP4120 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant mouse IL-17A protein

catalog :

ATGP4120

quantity :

10 ug

price :

120 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant mouse IL-17A protein

Domain :

26-158aa

Catalog number (SKU) :

ATGP4120

NCBI :

NP_034682.1

Description :

IL-17A, also known as CTLA‑8, is a cytokine that belongs to the Interleukin‑17 family. It produced by activated T cells and plays an important role in anti‑microbial and chronic inflammation. Mouse IL‑17A shares 61% amino acid sequence identity with human IL‑17A. It promotes protective mucosal and epidermal inflammation in response to microbial infection and induces chemokine production, neutrophil influx, and the production of antibacterial peptides. It can stimulate the expression of IL-6 and PTGS2/COX-2, as well as enhance the production of nitric oxide(NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis. Also, IL‑17A has been shown to exert either tumorigenic or anti‑tumor effects. Recombinant mouse IL-17A, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Interleukin-17A, IL17A, IL-17, IL-17A, Il17, Cytotoxic T-lymphocyte-associated antigen 8. Ctla-8, Ctla8

Concentration :

0.5mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Yao Z., et al. (1995) J. Immunol. 155:5483-5436.;; Kennedy J., et al. (1996) J. Interferon Cytokine Res. 16:611-617.

Purity :

> 95% by SDS-PAGE

Bioactivity Comment Only :

The activity is determined by the IL-6 ELISA in a using NIH/3T3 mouse embryonic fibroblast cells. The ED50 range ≤ 2 ng/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Mouse

Gene Category :

Immunology, Hormones & Cytokines

Molecular Weight :

16kDa (141aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Mouse IL-17A stimulates IL-6 secretion of the NIH/3T3 mouse embryonic fibroblast cells. The ED50 range ≤ 2 ng/ml.

Amino Acid Sequence :

AAIIPQSSAC PNTEAKDFLQ NVKVNLKVFN SLGAKVSSRR PSDYLNRSTS PWTLHRNEDP DRYPSVIWEA QCRHQRCVNA EGKLDHHMNS VLIQQEILVL KREPESCPFT FRVEKMLVGV GCTCVASIVR QAA

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala 26

Product Type Name :

Recombinant Protein

UniProt No. :

Q62386

Internal Search Terms :

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more info or order :

NKMAX product webpage