Recombinant human TREM2 protein | NKMAX ATGP4104 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human TREM2 protein

catalog :

ATGP4104

quantity :

10 ug

price :

110 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human TREM2 protein

Domain :

19-174aa

Catalog number (SKU) :

ATGP4104

NCBI :

NP_061838.1

Description :

TREM2, also known as Triggering receptor expressed on myeloid cells 2 isoform 1, is a membrane protein that forms a receptorsignaling complex with the TYRO protein tyrosine kinase binding protein. This protein is found in immune cells termed myeloid cells, which include macrophages, granulocytes, monocytes, and dendritic cells. It functions in immune response and maybe involved in chronic inflammation by triggering the production ofconstitutive inflammatory cytokines. It also promotes the differentiation and function of osteoclasts, the production of inflammatory cytokines by adipocytes, insulin resistance, and the phagocytic clearance of bacteria. Defects in TREM2 are acause of polycystic lipomembranous osteodysplasia with sclerosingleukoencephalopathy (PLOSL). In addition, TREM2 is overexpressed in many tumor types and has anti-inflammatory activities. It might therefore be a good therapeutic target. Recombinant human TREM2, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

triggering receptor expressed on myeloid cells 2 isoform 1, triggering receptor expressed on myeloid cells 2, triggering receptor expressed on myeloid cells 2a, TREM-2, Trem2a, Trem2b, Trem2c

Concentration :

1mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Bouchon A., et al (2000). J. Immunol. 164:4991-4995.;; N' Diaye EN, et al.(2009). J Cell Biol. 184:215-223.;;

Purity :

> 95% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

18.2kDa (162aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

HNTTVFQGVA GQSLQVSCPY DSMKHWGRRK AWCRQLGEKG PCQRVVSTHN LWLLSFLRRW NGSTAITDDT LGGTLTITLR NLQPHDAGLY QCQSLHGSEA DTLRKVLVEV LADPLDHRDA GDLWFPGESE SFEDAHVEHS ISRSLLEGEI PFPPTS

Tag :

His-Tag

Expression System :

HEK293

Predicted nterm :

His19

Product Type Name :

Recombinant Protein

UniProt No. :

Q9NZC2

Internal Search Terms :

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more info or order :

NKMAX product webpage