Recombinant human B7-H6 protein | NKMAX ATGP4100 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human B7-H6 protein

catalog :

ATGP4100

quantity :

10 ug

price :

160 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human B7-H6 protein

Domain :

25-262aa

Catalog number (SKU) :

ATGP4100

NCBI :

NP_001189368.1

Description :

B7-H6, also known as NCR3LG1, is a member of the B7 family of immune co‑stimulatory proteins. B7-H6 is as a cell-surface ligand for the NKp30-activating receptor expressed on natural killer cells. It is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, and is consistent with the detection of NKp30 binding sites on many tumors. The expression of NKp30 ligands on tumor cells correlates with tumor cell sensitivity to NKp30‑dependent cell lysis. Recombinant human B7-H6, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

Natural cytotoxicity triggering receptor 3 ligand 1, B7 homolog 6, NCR3LG1, B7H6, DKFZp686O24166

Concentration :

0.5mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Brandt C.S., et al. (2009) J. Exp. Med. 206:1495-1503.;; Zou, W., et al. (2008) Nat Rev Immunol. 8:467-477.;; Byrd A., et al. (2007) PLoS ONE. 2:e1339.

Purity :

> 95% by SDS-PAGE

Bioactivity Comment Only :

Measured by its binding ability in a functional ELISA with Human NCR3. The ED50 range ≤500 ng/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

53.6kDa (477aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human NCR3 is coated at 2 ug/ml (100 ul/well) can bind Human B7-H6. The ED50 range ≤500 ng/ml.

Amino Acid Sequence :

DLKVEMMAGG TQITPLNDNV TIFCNIFYSQ PLNITSMGIT WFWKSLTFDK EVKVFEFFGD HQEAFRPGAI VSPWRLKSGD ASLRLPGIQL EEAGEYRCEV VVTPLKAQGT VQLEVVASPA SRLLLDQVGM KENEDKYMCE SSGFYPEAIN ITWEKQTQKF PHPIEISEDV ITGPTIKNMD GTFNVTSCLK LNSSQEDPGT VYQCVVRHAS LHTPLRSNFT LTAARHSLSE TEKTDNFS

Tag :

hIgG-His-Tag

Expression System :

HEK293

Predicted nterm :

Asp 25

Product Type Name :

Recombinant Protein

UniProt No. :

Q68D85

Internal Search Terms :

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more info or order :

NKMAX product webpage