Recombinant human IL-4I1 protein | NKMAX ATGP4099 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human IL-4I1 protein

catalog :

ATGP4099

quantity :

10 ug

price :

160 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human IL-4I1 protein

Domain :

22-567aa

Catalog number (SKU) :

ATGP4099

NCBI :

NP_690863

Description :

IL-4I1, also known as FIG1, is a secreted L-amino-acid oxidase that acts as a key immunoregulator. It is highly expressed in primary metastinal B-cell lymphomas. This protein acts as a negative regultaotr of anti-tumor immunity by mediating Trp degradation via ans indole pyruvate pathway that activates the transcription factor AHR. IL-4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer. IL-41I also regulates M2 macrophage polarization by inhibiting T-cell activation and has antibacterial properties by inhibiting growth of Gram negative and Gram positive bacteria through the production of NH4+ and H2O2. Recombinant human IL-4I1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Interleukin 4 induced 1, FIG1, LAAO, LAO, L-amino-acid oxidase isoform 1, L-amino-acid oxidase, IL4-induced protein 1, Fig-1, IL4I1, hIL4I1

Concentration :

0.25mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid in. 20mM MES (pH5.5) containing 0.1M NaCl, 40% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Cousin C., et al, (2015) Eur J Immunol. 45:1772-1782.;; Sadik A., et al, (2020) Cell. 182:1525-1270.;; Mulder K., et al, (2021) Immunity. 54:1883-1900.;;

Purity :

> 90% by SDS-PAGE

Bioactivity Comment Only :

Specific activity is > 300 pmol/min/ug, and defined as the amount of enzyme that oxidize 3-phenylpyruvate at pH 7.0 at 25C.

Applications :

SDS-PAGE, Enzyme Activity

Antigen Species :

Human

Gene Category :

Apoptosis, Cell Cycle

Molecular Weight :

61.8kDa (555aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Specific activity is > 300 pmol/min/ug, and defined as the amount of enzyme that oxidize 3-phenylpyruvate at pH 7.0 at 25C.

Amino Acid Sequence :

QDWKAER SQDPFEKCMQ DPDYEQLLKV VTWGLNRTLK PQRVIVVGAG VAGLVAAKVL SDAGHKVTIL EADNRIGGRI FTYRDQNTGW IGELGAMRMP SSHRILHKLC QGLGLNLTKF TQYDKNTWTE VHEVKLRNYV VEKVPEKLGY ALRPQEKGHS PEDIYQMALN QALKDLKALG CRKAMKKFER HTLLEYLLGE GNLSRPAVQL LGDVMSEDGF FYLSFAEALR AHSCLSDRLQ YSRIVGGWDL LPRALLSSLS GLVLLNAPVV AMTQGPHDVH VQIETSPPAR NLKVLKADVV LLTASGPAVK RITFSPPLPR HMQEALRRLH YVPATKVFLS FRRPFWREEH IEGGHSNTDR PSRMIFYPPP REGALLLASY TWSDAAAAFA GLSREEALRL ALDDVAALHG PVVRQLWDGT GVVKRWAEDQ HSQGGFVVQP PALWQTEKDD WTVPYGRIYF AGEHTAYPHG WVETAVKSAL RAAIKINSRK GPASDTASPE GHASDMEGQG HVHGVASSPS HDLAKEEGSH PPVQGQLSLQ NTTHTRTSH

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

Q96RQ9

Internal Search Terms :

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more info or order :

NKMAX product webpage