Recombinant mouse Cathepsin C/DPPI protein | NKMAX ATGP4093 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant mouse Cathepsin C/DPPI protein

catalog :

ATGP4093

quantity :

10 ug

price :

150 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant mouse Cathepsin C/DPPI protein

Domain :

25-462aa

Catalog number (SKU) :

ATGP4093

NCBI :

NP_034112.3

Description :

Cathepsin C/DPPI, also known as dipeptidyl peptidase I , is a lysosomal exo-cysteine protease belonging to the peptidase C1 protein family, a subgroup of the cysteine cathepsins. It catalyses excision of dipeptides from the N-terminus of protein and peptide substrates, except if the amino group of the N-terminus is blocked. Also, It appears to be a central coordinator for activation of many serine proteases in immune/inflammatory cells. Defects in the Cathepsin C have been shown to be a cause of Papillon-Lefevre disease, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Also, It plays a key role in the activation of several degradative enzymes linked to tissue destruction in inflammatory diseases. Recombinant mouse Cathepsin C, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

Cathepsin C, AI047818, CatC, DP, DPP1, DPPI, Cathepsin J, Dipeptidyl peptidase isoform 1, Dipeptidyl peptidase 1, Dipeptidyl transferase, CTSC

Concentration :

0.5mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Dahl SW., et al, (2001) Biochemistry. 40:1671-1678. ;; Turk D., et al, (2001) The EMBO Journal. 20:6570-6582.

Purity :

> 95% by SDS-PAGE

Bioactivity Comment Only :

Specific activity is > 50,000 pmol/min/ug and is defined as the amount of enzyme that hydrolyze 1pmole of Gly-Arg-AMC per minute at pH 6.0 at 37C.

Applications :

SDS-PAGE, Enzyme Activity

Antigen Species :

Mouse

Gene Category :

Enzymes & Proteases

Molecular Weight :

50.5kDa (444aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Specific activity is > 50,000 pmol/min/ug and is defined as the amount of enzyme that hydrolyze 1pmole of Gly-Arg-AMC per minute at pH 6.0 at 37C.

Amino Acid Sequence :

DTPANCTYPD LLGTWVFQVG PRSSRSDINC SVMEATEEKV VVHLKKLDTA YDELGNSGHF TLIYNQGFEI VLNDYKWFAF FKYEVRGHTA ISYCHETMTG WVHDVLGRNW ACFVGKKVES HIEKVNMNAA HLGGLQERYS ERLYTHNHNF VKAINTVQKS WTATAYKEYE KMSLRDLIRR SGHSQRIPRP KPAPMTDEIQ QQILNLPESW DWRNVQGVNY VSPVRNQESC GSCYSFASMG MLEARIRILT NNSQTPILSP QEVVSCSPYA QGCDGGFPYL IAGKYAQDFG VVEESCFPYT AKDSPCKPRE NCLRYYSSDY YYVGGFYGGC NEALMKLELV KHGPMAVAFE VHDDFLHYHS GIYHHTGLSD PFNPFELTNH AVLLVGYGRD PVTGIEYWII KNSWGSNWGE SGYFRIRRGT DECAIESIAV AAIPIPKL

Tag :

His-Tag

Expression System :

HEK293

Predicted nterm :

Asp25

Product Type Name :

Recombinant Protein

UniProt No. :

P97821

Internal Search Terms :

ATGP4093-10ug,ATGP4093-20ug,ATGP4093-50ug,ATGP4093-100ug,ATGP4093-250ug,ATGP4093-500ug,ATGP4093-1mg, ATGP4093-10,ATGP4093-20,ATGP4093-50,ATGP4093-100,ATGP4093-250,ATGP4093-500,ATGP4093-1

more info or order :

NKMAX product webpage