product summary
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company name :
NKMAX
product type :
protein
product name :
Recombinant mouse IL-3R alpha/IL3RA protein
catalog :
ATGP4091
quantity :
10 ug
price :
83 USD
more info or order :
NKMAX product webpage
product information
Product Type :
Proteins
Item Name :
Recombinant mouse IL-3R alpha/IL3RA protein
Domain :
17-331aa
Catalog number (SKU) :
ATGP4091
NCBI :
NP_032395
Description :
IL-3R alpha/CD123, also known as interleukin 3 receptor subunit alpha, is a member of the type 1 cytokine receptor family and type 5 subfamily. It is expressed on multiple cell types, including endothelial cells, monocytes, eosinophils, basophils plus mast cells, and plasmacytoid CD4+ T cells. It serves as a low affinity binding protein for monomeric IL‑3. The IL‑3 and IL‑3 R alpha complex likely interacts with a preformed signaling homodimer comprised of either beta IL-3 or beta c chains. The extracellular domain of mouse IL‑3 R alpha/CD123 shares only 44% and 29% aa sequence identity with rat and human IL‑3 R alpha, respectively. Nevertheless, human IL‑3 is reported to be active on the mouse receptor complex that is expressed on select cell types. Also, the specific alpha subunit of the interleukin 3 receptor is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. Recombinant mouse IL-3R alpha/CD123, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Alternative Names :
Interleukin-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, Interleukin-3 receptor class II alpha chain, L3RA, CD123, hIL-3Ra, IL3R, SUT-1
Concentration :
0.25mg/ml (determined by Absorbance at 280nm)
Formulation :
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 30% glycerol
Storage :
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
General References :
Kosugi H., et al, (1995) Biochem. Biophys. Res. Commun. 208:360-367.;; Testa U., et al, (2004) Leukemia. 18:219-226.
Purity :
> 90% by SDS-PAGE
Applications :
SDS-PAGE
Antigen Species :
Mouse
Gene Category :
Immunology, Hormones & Cytokines
Molecular Weight :
61.5kDa (554aa)
Endotoxin :
< 1 EU per 1ug of protein (determined by LAL method)
Amino Acid Sequence :
SDLAAVREAP PTAVTTPIQN LHIDPAHYTL SWDPAPGADI TTGAFCRKGR DIFVWADPGL ARCSFQSLSL CHVTNFTVFL GKDRAVAGSI QFPPDDDGDH EAAAQDLRCW VHEGQLSCQW ERGPKATGDV HYRMFWRDVR LGPAHNRECP HYHSLDVNTA GPAPHGGHEG CTLDLDTVLG STPNSPDLVP QVTITVNGSG RAGPVPCMDN TVDLQRAEVL APPTLTVECN GSEAHARWVA RNRFHHGLLG YTLQVNQSSR SEPQEYNVSI PHFWVPNAGA ISFRVKSRSE VYPRKLSSWS EAWGLVCPPE VMPVK
Tag :
hIgG-His-Tag
Expression System :
Baculovirus
Predicted nterm :
Ser 17
Product Type Name :
Recombinant Protein
UniProt No. :
P26952
Internal Search Terms :
Interleukin-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, Interleukin-3 receptor class II alpha chain, L3RA, CD123, hIL-3Ra, IL3R, SUT-1, IL3RAY, IL3RX, IL3RY, CDW123, Interleukin 3 receptor subunit alpha, IL 3R subunit alpha, IL 3R alpha, Interleukin 3 receptor class II alpha chain, hIL 3Ra, SUT 1, ATGP4091-10ug, ATGP4091-20ug, ATGP4091-50ug, ATGP4091-100ug, ATGP4091-250ug, ATGP4091-500ug, ATGP4091-1mg, ATGP4091-010, ATGP4091-020, ATGP4091-050, ATGP4091-100, ATGP4091-250, ATGP4091-500, ATGP4091-01M
more info or order :
NKMAX product webpage
company information
NKMAX
SNUH Health Care Innovation Park 6F
172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
https://www.nkmaxbio.com
82-31-8017-8114
headquarters: South Korea
NKMAX Co. Ltd. is a biotech company that manufactures and supplies a unique line of quality proteins and antibodies worldwide to both researchers and retailers.