Recombinant human Podocalyxin protein | NKMAX ATGP4090 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human Podocalyxin protein

catalog :

ATGP4090

quantity :

10 ug

price :

120 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human Podocalyxin protein

Domain :

23-429aa

Catalog number (SKU) :

ATGP4090

NCBI :

NP_005388.2

Description :

Podocalyxin, also known as PODXL, is a member of the CD34 sialomucin protein family. It is present in glomerular podocytes, endothelial cells, glandular cells in fallopian tube, uterus. A soluble form of Podocalyxin can be released into the urine of women with pre-eclampsia. It has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2. And Its interactions with L-Selectin and E-Selectin mediate the tethering of lymphocytes and metastatic tumor cells to the vascular endothelium. It is upregulated in a number of cancers and is frequently associated with poor prognosis. Based on patient survival data, high level of PODXL transcripts in tumor cells is associated with poor prognosis in renal cancer. Recombinant human Podocalyxin, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

PODXL, Podocalyxin, Podocalyxin isoform 2, GCTM, GCTM-2 antigen, Gp200, Podocalyxin-like protein 1, PCLP, PCLP1, PCLP-1, PCpodocalyxin, podocalyxin-like, PDX, gp135, PC, PODXL1

Concentration :

1 mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol.

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Nielsen, J.S. and K.M. McNagny (2009) J. Am. Soc. Nephrol. 20:1669-1676.;; Nielsen JS, McNagny KM (2008). Journal of Cell Science. 121: 3683–3692.;; Takeda T, et al. (2001). The Journal of Clinical Investigation. 108: 289–301.

Purity :

> 95% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Signal Transduction, Cytoskeleton

Molecular Weight :

43.1kDa (416aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

SPSPSPS PSQNATQTTT DSSNKTAPTP ASSVTIMATD TAQQSTVPTS KANEILASVK ATTLGVSSDS PGTTTLAQQV SGPVNTTVAR GGGSGNPTTT IESPKSTKSA DTTTVATSTA TAKPNTTSSQ NGAEDTTNSG GKSSHSVTTD LTSTKAEHLT TPHPTSPLSP RQPTSTHPVA TPTSSGHDHL MKISSSSSTV AIPGYTFTSP GMTTTLPSSV ISQRTQQTSS QMPASSTAPS SQETVQPTSP ATALRTPTLP ETMSSSPTAA STTHRYPKTP SPTVAHESNW AKCEDLETQT QSEKQLVLNL TGNTLCAGGA SDEKLISLIC RAVKATFNPA QDKCGIRLAS VPGSQTVVVK EITIHTKLPA KDVYERLKDK WDELKEAGVS DMKLGDQGPP EEAEDRFSMP

Tag :

His-Tag

Expression System :

HEK293

Predicted nterm :

Asp

Product Type Name :

Recombinant Protein

UniProt No. :

O00592

Internal Search Terms :

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more info or order :

NKMAX product webpage