Recombinant human TL1A/TNFSF15 protein | NKMAX ATGP4084 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human TL1A/TNFSF15 protein

catalog :

ATGP4084

quantity :

10 ug

price :

130 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human TL1A/TNFSF15 protein

Domain :

72-251aa

Catalog number (SKU) :

ATGP4084

NCBI :

NP_005109.2

Description :

Tumor necrosis factor ligand superfamily member 15, also known TNFSF15, belongs to the TNF superfamily. TNFSF15 is predominantly expressed in endothelial cells and its expression is inducible by TNFalpha and IL1alpha. TNFSF15 is an angiogenesis inhibitor of the TNF family and functions in part by directly inhibiting endothelial cell proliferation. TNFSF15 may act as an autocrine factor to induce apoptosis in endothelial cells via activation of multiple signaling pathways, including stress protein kinases and certain caspases. Recombinant human TNFSF15 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

TNF superfamily member 15, TNF ligand-related molecule 1, TL1, Vascular endothelial cell growth inhibitor, VEGI, TNF superfamily ligand TL1A, TL1A, Vascular endothelial growth inhibitor-192A, VEGI192A

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.5) containing 0.15M NaCl, 40% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Migone T S., et al. (2002) Immunity. 16:479.;; Zhai Y., et al. (1999) FASEB J.13:181-189.

Purity :

> 90% by SDS-PAGE

Bioactivity Comment Only :

Measured by its ability to induce apoptosis in TF-1 human erythroleukemic cells in the presence of cycloheximaide. The ED50 range ≤ 100ng/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

22.7 kDa (201aa) confirmed by MALDI-TOF

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human TNFSF15 induces apoptosis in TF-1 human erythroleukemic cells in the presence of cycloheximaide. The ED50 range ≤ 100 ng/ml.

Amino Acid Sequence :

LKGQEFAPS HQQVYAPLRA DGDKPRAHLT VVRQTPTQHF KNQFPALHWE HELGLAFTKN RMNYTNKFLL IPESGDYFIY SQVTFRGMTS ECSEIRQAGR PNKPDSITVV ITKVTDSYPE PTQLLMGTKS VCEVGSNWFQ PIYLGAMFSL QEGDKLMVNV SDISLVDYTK EDKTFFGAFL L

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

O95150

Internal Search Terms :

TL1A, TNFSF15, Tumor necrosis factor ligand superfamily member 15, TL1, TL1A, VEGI, VEGI192A,ATGP4084-10ug,ATGP4084-20ug,ATGP4084-50ug,ATGP4084-100ug,ATGP4084-250ug,ATGP4084-500ug,ATGP4084-1mg,ATGP4084-10,ATGP4084-20,ATGP4084-50,ATGP4084-100,ATGP4084-250,ATGP4084-500,ATGP4084-1

more info or order :

NKMAX product webpage