Recombinant SARS-CoV-2 (2019-nCoV) Nucleocapsid Protein | NKMAX ATGP4080 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant SARS-CoV-2 (2019-nCoV) Nucleocapsid Protein

catalog :

ATGP4080

quantity :

10 ug

price :

120 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant SARS-CoV-2 (2019-nCoV) Nucleocapsid Protein

Domain :

1-419aa

Catalog number (SKU) :

ATGP4080

NCBI :

YP_009724397.2

Description :

An epidemic of acute respiratory syndrome in humans, which appeared in Wuhan, China in December 2019, was caused by a novel coronavirus (SARS-CoV-2). This disease was named as "Coronavirus Disease 2019" (COVID19). This virus shares highly homological sequence with SARS-CoV, and causes acute, highly lethal pneumonia coronavirus disease 2019 (COVID-19) with clinical symptoms similar to those reported for SARS-CoV and MERSCoV. The genome of this and other emerging pathogenic human CoVs encodes four major structural proteins [spike (S), envelope (E), membrane (M), and nucleocapsid (N)], approximately 16 nonstructural proteins (nsp1–16), and five to eight accessory proteins. Among them, the nucleocapsid protein acts as a viral suppressor of RNA interference in cells. The presence of circulating N protein in SARS patient may be be connected with its mode of expression in the viral replicative cycle. Also, Animal coronavirus have display that the nucleocapsid protein plays an important role in viral pathogenesis and replication. Recombinant SARS-CoV-2 (2019-nCoV) Nucleocapsid, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

nucleocapsid phosphoprotein, Nucleoprotein, NC, Protein N,covid19, COVID-19, COVID-19 virus, HCoV-19, Human coronavirus 2019, SARS2, Severe acute respiratory syndrome coronavirus 2, 2019-nCoV, N

Concentration :

0.5mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 50% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Che, X., et al, (2004) J. Clin. Microbiol. 42:2629-2635.;; Mu, J., et al. (2020) Sci. China Life Sci. 9:1413-1416.;; Wu, F. et al. (2020) Nature. 579:265-269.;; Ortega, J.T. et al. (2020) EXCLI J. 19:410-417.;; Wanbo T., et al, (2020) Cell. Mol. Immunol. 17:613-620.;; Gorbalenya A., et al (2020) Nat. Microbiol. 5:536-544.;; Tortorici, M.A. and D. Veesler (2019). Adv. Virus Res. 105:93-116.

Purity :

> 90% by SDS - PAGE

Applications :

SDS-PAGE

Antigen Species :

SARS-CoV-2 (2019-nCoV)

Gene Category :

Virus

Molecular Weight :

46.4kDa (425aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

MSDNGPQNQR NAPRITFGGP SDSTGSNQNG ERSGARSKQR RPQGLPNNTA SWFTALTQHG KEDLKFPRGQ GVPINTNSSP DDQIGYYRRA TRRIRGGDGK MKDLSPRWYF YYLGTGPEAG LPYGANKDGI IWVATEGALN TPKDHIGTRN PANNAAIVLQ LPQGTTLPKG FYAEGSRGGS QASSRSSSRS RNSSRNSTPG SSRGTSPARM AGNGGDAALA LLLLDRLNQL ESKMSGKGQQ QQGQTVTKKS AAEASKKPRQ KRTATKAYNV TQAFGRRGPE QTQGNFGDQE LIRQGTDYKH WPQIAQFAPS ASAFFGMSRI GMEVTPSGTW LTYTGAIKLD DKDPNFKDQV ILLNKHIDAY KTFPPTEPKK DKKKKADETQ ALPQRQKKQQ TVTLLPAADL DDFSKQLQQS MSSADSTQA

Tag :

His-Tag

Expression System :

HEK293

Predicted nterm :

Met 1

Product Type Name :

Recombinant Protein

UniProt No. :

P0DTC9

Internal Search Terms :

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more info or order :

NKMAX product webpage