Recombinant canine IL-17A protein | NKMAX ATGP4068 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant canine IL-17A protein

catalog :

ATGP4068

quantity :

10 ug

price :

130 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant canine IL-17A protein

Domain :

29-155aa

Catalog number (SKU) :

ATGP4068

NCBI :

NP_001159350.1

Description :

IL-17A, also known as CTLA8, is a member of the IL-17 family of cytokines. This family demonstrate a structural motif termed a cysteine knot that also characterizes a large superfamily of growth factors. The IL-17 family of cytokines includes six members, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F. IL-17A main funcion is stimulates production of IL-6, prostaglandin E and nitric oxide. And other inflammatory cytokines(TNF-alpha, IL-1 beta and IFN -gamma) leads to up-regulation of gene expression and progression and amplification of local inflammation. In addition, it serves induction of co-stimulatory molecules such as ICAM-1 and other cytokines, thereby supporting T cell activation. IL-17 expression has been associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. Recombinant canine IL-17A, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

IL17A, IL17, IL-17A, Interleukin 17A, Interleukin-17A, cytotoxic T-lymphocyte-associated serine esterase 8, CTLA-8, CTLA8

Concentration :

0.5 mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol.

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Moseley TA., et al, (2003) Cytokine & Growth Factor Reviews. 14: 155–174.;; Afzali, B. et al. (2007) Clin. Exp. Immunol. 148:32-46.;; Fossiez, F. et al. (1996) J. Exp. Med. 183:2593-2603.;;

Purity :

> 90% by SDS - PAGE

Bioactivity Comment Only :

The activity is determined by the IL-6 ELISA in a using NIH/3T3 mouse embryonic fibroblast cells. The ED50 range ≤ 10 ng/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Canine

Gene Category :

Immunology, Hormones & Cytokines

Molecular Weight :

15.6kDa (133aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Canine IL-17A stimulates IL-6 secretion of the NIH/3T3 mouse embryonic fibroblast cells. The ED50 range ≤ 10 ng/ml.

Amino Acid Sequence :

FPQNPGCRNT EDKNFPQHVK VNLNILNRNT NSRRPSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CVNNEGNINY HMNSVPIQQE ILVLRRESQH CPHSFRLEKM LVAVGCTCVT PIVRHVA

Tag :

His-Tag

Expression System :

HEK293

Predicted nterm :

Phe 29

Product Type Name :

Recombinant Protein

UniProt No. :

C6L8D7

Internal Search Terms :

ATGP4068-10ug,ATGP4068-20ug,ATGP4068-50ug,ATGP4068-100ug,ATGP4068-250ug,ATGP4068-500ug,ATGP4068-1mg,ATGP4068-10,ATGP4068-20,ATGP4068-50,ATGP4068-100,ATGP4068-250,ATGP4068-500,ATGP4068-1

more info or order :

NKMAX product webpage