Recombinant human CCL2/MCP-1 protein | NKMAX ATGP4067 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human CCL2/MCP-1 protein

catalog :

ATGP4067

quantity :

10 ug

price :

140 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human CCL2/MCP-1 protein

Domain :

24-99aa

Catalog number (SKU) :

ATGP4067

NCBI :

NP_002973.1

Description :

CCL2(Chemokine ligand 2), as known as MCP-1(monocyte chemotactic protein-1), is a small cytokine belonging to the CC chemokine family. This protein recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection. It binds to chemokine receptors CCR2 and CCR4. It also induces enzyme and cytokine release by monocytes, NK cells and lymphocytes, and histamine release by basophils, primarily due to interaction with CCR2 receptors on these cells. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. Recombinant human CCL2/JE/MCP-1, fused to His-tag at C-terminus, was expressed in HEK293 and purified by using conventional chromatography techniques.

Alternative Names :

SMC-CF, Small inducible cytokine subfamily A member 2, Small inducible cytokine A2, SCYA2, Monocyte secretory protein JE, Monocyte chemotactic protein 1 homologous to mouse Sig-je, Monocyte chemotactic and activating factor, MGC9434, MCP-1, MCP1, MCAF, HC11, GDCF-2, C-C motif chemokine ligand 2

Concentration :

0.25mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Foresti ML, Arisi GM, et al. (2009). J Neuroinflammation. 6:40.;; Semple BD, Bye N, et al. (2010). J Cereb Blood Flow Metab. 30:769-782.

Purity :

> 90% by SDS - PAGE

Bioactivity Comment Only :

Measured its ability to chemoattract using THP-1 human acute monocytic leukemia cells. The ED50 range ≤ 30 ng/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Immunology, Hormones & Cytokines

Molecular Weight :

9.5kDa (82aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human CCL2/MCP-1 chemoattracts the the THP-1 human acute monocytic leukemia cells. The ED50 range ≤ 30 ng/ml.

Amino Acid Sequence :

QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKT

Tag :

His-Tag

Expression System :

HEK293

Predicted nterm :

Gln 24

Product Type Name :

Recombinant Protein

UniProt No. :

P13500

Internal Search Terms :

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more info or order :

NKMAX product webpage