product summary
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company name :
NKMAX
product type :
protein
product name :
Recombinant human Epiregulin protein
catalog :
ATGP4066
quantity :
10 ug
price :
160 USD
more info or order :
NKMAX product webpage
product information
Product Type :
Proteins
Item Name :
Recombinant human Epiregulin protein
Domain :
63-108aa
Catalog number (SKU) :
ATGP4066
NCBI :
NP_001423.1
Description :
Epiregulin is a member of the epidermal growth factor family. It is expressed primarily in the placenta and macrophages and high level expression has also been detected in various carcinomas. This protein contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation. Epiregulin is growth factors involved in cancer development. Deregulated epiregulin activity appears to contribute to the progression of a number of different malignancies, including cancers of the bladder, stomach, colon, breast, lung, head and neck, and liver. It inhibit the growth of several epithelial tumor cells and stimulated the growth of fibroblasts and various other types of cells. In addition, it has been implicated in the implantation process during pregnancy. Recombinant human Epiregulin, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Alternative Names :
Epiregulin, Ep, EPR, ER, Proepiregulin, EREG
Concentration :
0.25mg/ml (determined by Absorbance at 280nm)
Formulation :
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Storage :
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
General References :
Shaowei Li., et al, (2008) Anticancer Res. 105:3539-3544. ;; Yamamoto T., et al, (2004) Anticancer Res. 24:2007-2010.;; Cho MC., et al, (2008) Biochem. Biophys. Res. 377:832-837.
Purity :
> 90% by SDS - PAGE
Bioactivity Comment Only :
Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The ED50 range ≤ 1 ug/ml.
Applications :
SDS-PAGE, Bioactivity
Antigen Species :
Human
Gene Category :
Signal Transduction, Hormones & Cytokines
Molecular Weight :
32.6kDa (289aa)
Endotoxin :
< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment and Pics :
Human Epiregulin stimulates cell proliferation of the Balb/3T3 mouse embryonic fibroblast cells. The ED50 range ≤ 1 ug/ml.
Amino Acid Sequence :
VSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL
Tag :
hIgG-His-Tag
Expression System :
HEK293
Predicted nterm :
Asp
Product Type Name :
Recombinant Protein
UniProt No. :
O14944
Internal Search Terms :
ATGP4066-10ug,ATGP4066-20ug,ATGP4066-50ug,ATGP4066-100ug,ATGP4066-250ug,ATGP4066-500ug,ATGP4066-1mg,ATGP4066-10,ATGP4066-20,ATGP4066-50,ATGP4066-100,ATGP4066-250,ATGP4066-500,ATGP4066-1
more info or order :
NKMAX product webpage
company information
NKMAX
SNUH Health Care Innovation Park 6F
172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
https://www.nkmaxbio.com
82-31-8017-8114
headquarters: South Korea
NKMAX Co. Ltd. is a biotech company that manufactures and supplies a unique line of quality proteins and antibodies worldwide to both researchers and retailers.