Recombinant human TIE1 protein | NKMAX ATGP4062 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human TIE1 protein

catalog :

ATGP4062

quantity :

10 ug

price :

140 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human TIE1 protein

Domain :

22-759aa

Catalog number (SKU) :

ATGP4062

NCBI :

NP_005415.1

Description :

Tie-1, as known as tyrosine kinase with immunoglobulin like and EGF like domains 1, is an angiopoitein receptor. It is expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. However it has also been shown to be expressed in immature hematopoietic cells and platelets. It upregulates the cell adhesion molecules(CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Also, It has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis. Recombinant human Tie-1, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

Tyrosine-protein kinase receptor Tie-1 isoform 1, tyrosine kinase with immunoglobulin like and EGF like domains 1, JTK14, TIE, TIE1, LMPHM11

Concentration :

0.5mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid. In 20mM Tris-HCl (pH 8.0) containing 0.1M NaCl, 50% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Marron MB., et al, (2000) Adv Exp Med Biol. 476:35-46.;; Li K., et al, (2010) Blood. 115:133-139.;; Zhang X., et al, (2020) Cancers. 12:1705.;; Carlantoni C., et al, (2021) Dev Biol. 469:54-67.;;

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Signal Transduction

Molecular Weight :

106.8kDa (977aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

AVDLTLLANL RLTDPQRFFL TCVSGEAGAG RGSDAWGPPL LLEKDDRIVR TPPGPPLRLA RNGSHQVTLR GFSKPSDLVG VFSCVGGAGA RRTRVIYVHN SPGAHLLPDK VTHTVNKGDT AVLSARVHKE KQTDVIWKSN GSYFYTLDWH EAQDGRFLLQ LPNVQPPSSG IYSATYLEAS PLGSAFFRLI VRGCGAGRWG PGCTKECPGC LHGGVCHDHD GECVCPPGFT GTRCEQACRE GRFGQSCQEQ CPGISGCRGL TFCLPDPYGC SCGSGWRGSQ CQEACAPGHF GADCRLQCQC QNGGTCDRFS GCVCPSGWHG VHCEKSDRIP QILNMASELE FNLETMPRIN CAAAGNPFPV RGSIELRKPD GTVLLSTKAI VEPEKTTAEF EVPRLVLADS GFWECRVSTS GGQDSRRFKV NVKVPPVPLA APRLLTKQSR QLVVSPLVSF SGDGPISTVR LHYRPQDSTM DWSTIVVDPS ENVTLMNLRP KTGYSVRVQL SRPGEGGEGA WGPPTLMTTD CPEPLLQPWL EGWHVEGTDR LRVSWSLPLV PGPLVGDGFL LRLWDGTRGQ ERRENVSSPQ ARTALLTGLT PGTHYQLDVQ LYHCTLLGPA SPPAHVLLPP SGPPAPRHLH AQALSDSEIQ LTWKHPEALP GPISKYVVEV QVAGGAGDPL WIDVDRPEET STIIRGLNAS TRYLFRMRAS IQGLGDWSNT VEESTLGNGL QAEGPVQESR AAEEGLDQ

Tag :

hIgG-His-Tag

Expression System :

HEK293

Predicted nterm :

Ala 22

Product Type Name :

Recombinant Protein

UniProt No. :

P35590

Internal Search Terms :

ATGP4062-10ug,ATGP4062-20ug,ATGP4062-50ug,ATGP4062-100ug,ATGP4062-250ug,ATGP4062-500ug,ATGP4062-1mg,ATGP4062-10,ATGP4062-20,ATGP4062-50,ATGP4062-100,ATGP4062-250,ATGP4062-500,ATGP4062-1

more info or order :

NKMAX product webpage