Recombinant human TNFRSF7/CD27 protein | NKMAX ATGP4060 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human TNFRSF7/CD27 protein

catalog :

ATGP4060

quantity :

10 ug

price :

120 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human TNFRSF7/CD27 protein

Domain :

20-191aa

Catalog number (SKU) :

ATGP4060

NCBI :

NP_001233.1

Description :

CD27, as known as TNFRSF7, is a member of the tumor necrosis factor receptor superfamily. It has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has an important role in the generation of T cell immunity and is an robust marker for normal memory B cells. Also, this protein plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis. As a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD 70 on lymphocytes and dendritic cells. It binds to ligand CD70, and CD27/CD70 co-stimulatory system promote T, B and NK cell responses and particularly the CTL response, and is a target in cancer immunotherapy. Recombinant human CD27, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 and purified by using conventional chromatography techniques.

Alternative Names :

CD27L receptor, T-cell activation antigen CD27, T14, Tumor necrosis factor receptor superfamily member 7, TNFRSF7, T cell antivation antigen S152, TP55

Concentration :

0.5mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Clemente A., et al. (2013) Clin. Exp. Immunol. 174:97-108.;; Huang J., et al. (2013) J. Immunol. 190:6250-6258.

Purity :

> 95% by SDS - PAGE

Bioactivity Comment Only :

Measured by its binding ability in a functional ELISA with Human CD27 Ligand/TNFSF7 (CAT# ATGP3336). The ED50 range ≤ 0.8 ug/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

46.2kDa (411aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human CD27 Ligand/TNFSF7 (CAT# ATGP3336) is coated at 10 ug/ml (100 ul/well) can bind Human CD27/TNFRSF7. The ED50 range ≤ 0.8 ug/ml.

Amino Acid Sequence :

ATPAPKSCPE RHYWAQGKLC CQMCEPGTFL VKDCDQHRKA AQCDPCIPGV SFSPDHHTRP HCESCRHCNS GLLVRNCTIT ANAECACRNG WQCRDKECTE CDPLPNPSLT ARSSQALSPH PQPTHLPYVS EMLEARTAGH MQTLADFRQL PARTLSTHWP PQRSLCSSDF IR

Tag :

hIgG-His-Tag

Expression System :

HEK293

Predicted nterm :

Ala 20

Product Type Name :

Recombinant Protein

UniProt No. :

P26842

Internal Search Terms :

ATGP4060-10ug,ATGP4060-20ug,ATGP4060-50ug,ATGP4060-100ug,ATGP4060-250ug,ATGP4060-500ug,ATGP4060-1mg,ATGP4060-10,ATGP4060-20,ATGP4060-50,ATGP4060-100,ATGP4060-250,ATGP4060-500,ATGP4060-1

more info or order :

NKMAX product webpage